Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Experimental Neurology Year : 2016

Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

Abstract

Highlights x Excitatory GABA effect was implemented in a computational neural mass model x Dynamic emergence of depolarizing GABA triggers interictal to ictal transitions x Results suggest a major role of GABAergic interneurons in seizure onset x Model reproduces clinical patterns found in a severe infantile epilepsy
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Dates and versions

inserm-01341764 , version 1 (04-07-2016)

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Polina Kurbatova, Fabrice Wendling, Anna Kaminska, Anna Rosati, Rima Nabbout, et al.. Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.. Experimental Neurology, 2016, 283 (Pt A), pp.57-72. ⟨10.1016/j.expneurol.2016.05.037⟩. ⟨inserm-01341764⟩
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