Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.
Abstract
Highlights x Excitatory GABA effect was implemented in a computational neural mass model x Dynamic emergence of depolarizing GABA triggers interictal to ictal transitions x Results suggest a major role of GABAergic interneurons in seizure onset x Model reproduces clinical patterns found in a severe infantile epilepsy
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