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            <funder>TIME and LateTIME were supported by a grant from the National Heart, Lung, and Blood Institute under the cooperative agreement 5 UM1 HL087318-01. Part of the study was supported by European Union structural funds (Innovative Economy Operational Program POIG.01.01.02-00-109/09-00) to Dr Wojakowski.</funder>
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            <idno type="halRefHtml">&lt;i&gt;Circulation Research&lt;/i&gt;, 2015, 116 (8), pp.1346-60. &lt;a target="_blank" href="https://dx.doi.org/10.1161/CIRCRESAHA.116.304346"&gt;&amp;#x27E8;10.1161/CIRCRESAHA.116.304346&amp;#x27E9;&lt;/a&gt;</idno>
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                <title level="j">Circulation Research</title>
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                  <publisher>American Heart Association</publisher>
                  <biblScope unit="volume">116</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1346-60</biblScope>
                  <date type="datePub">2015-04-10</date>
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              <keywords scheme="author">
                <term xml:lang="en">anterior wall myocardial infarction</term>
                <term xml:lang="en">heart failure</term>
                <term xml:lang="en">meta-analysis</term>
                <term xml:lang="en">outcome assessment</term>
                <term xml:lang="en">stem cells</term>
              </keywords>
              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">Bone Marrow Transplantation</classCode>
              <classCode scheme="mesh">Ventricular Function, Left</classCode>
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              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Kaplan-Meier Estimate</classCode>
              <classCode scheme="mesh">Myocardial Contraction</classCode>
              <classCode scheme="mesh">Recovery of Function</classCode>
              <classCode scheme="mesh">Recurrence</classCode>
              <classCode scheme="mesh">Myocardial Infarction</classCode>
              <classCode scheme="mesh">Myocardium</classCode>
              <classCode scheme="mesh">Proportional Hazards Models</classCode>
              <classCode scheme="mesh">Prospective Studies</classCode>
              <classCode scheme="mesh">Randomized Controlled Trials as Topic</classCode>
              <classCode scheme="mesh">Regeneration</classCode>
              <classCode scheme="mesh">Ventricular Remodeling</classCode>
              <classCode scheme="mesh">Cerebrovascular Disorders</classCode>
              <classCode scheme="mesh">Risk Factors</classCode>
              <classCode scheme="mesh">Stroke Volume</classCode>
              <classCode scheme="mesh">Time Factors</classCode>
              <classCode scheme="mesh">Treatment Outcome</classCode>
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            <abstract xml:lang="en">
              <p>The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE-TIME; n=1252). The primary end point was freedom from combined major adverse cardiac and cerebrovascular events (including all-cause death, AMI recurrance, stroke, and target vessel revascularization). The secondary end point was freedom from hard clinical end points (death, AMI recurrence, or stroke), assessed with random-effects meta-analyses and Cox regressions for interactions. Secondary efficacy end points included changes in end-diastolic volume, end-systolic volume, and ejection fraction, analyzed with random-effects meta-analyses and ANCOVA. We reported weighted mean differences between cell therapy and control groups. No effect of cell therapy on major adverse cardiac and cerebrovascular events (14.0% versus 16.3%; hazard ratio, 0.86; 95% confidence interval, 0.63-1.18) or death (1.4% versus 2.1%) or death/AMI recurrence/stroke (2.9% versus 4.7%) was identified in comparison with controls. No changes in ejection fraction (mean difference: 0.96%; 95% confidence interval, -0.2 to 2.1), end-diastolic volume, or systolic volume were observed compared with controls. These results were not influenced by anterior AMI location, reduced baseline ejection fraction, or the use of MRI for assessing left ventricular parameters. This meta-analysis of individual patient data from randomized trials in patients with recent AMI revealed that intracoronary cell therapy provided no benefit, in terms of clinical events or changes in left ventricular function. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01098591.</p>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
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            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
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            <relation active="#struct-93263" type="direct"/>
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        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
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          <orgName type="acronym">UN</orgName>
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            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
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            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-306946" status="INCOMING">
          <orgName>Rikshospitalet</orgName>
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            <address>
              <country key="FR"/>
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        </org>
        <org type="institution" xml:id="struct-468263" status="VALID">
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          <orgName>Oslo University Hospital [Oslo]</orgName>
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            <address>
              <addrLine>Kirkeveien 166, 0450 Oslo</addrLine>
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            </address>
            <ref type="url">http://www.ous-research.no/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-520220" status="VALID">
          <orgName>Boston College</orgName>
          <orgName type="acronym">BC</orgName>
          <desc>
            <address>
              <addrLine>140 Commonwealth Avenue Chestnut Hill, MA 02467</addrLine>
              <country key="US"/>
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            <ref type="url">http://www.bc.edu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-91203" status="VALID">
          <idno type="ISNI">0000 0004 1936 9721</idno>
          <idno type="ROR">https://ror.org/04cvxnb49</idno>
          <orgName>Goethe University Frankfurt = Goethe-Universität Frankfurt am Main</orgName>
          <date type="start">1914-01-01</date>
          <desc>
            <address>
              <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.goethe-university-frankfurt.de/en?</ref>
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        </org>
        <org type="institution" xml:id="struct-307094" status="VALID">
          <idno type="ROR">https://ror.org/017zqws13</idno>
          <idno type="Wikidata">Q238101</idno>
          <orgName>University of Minnesota [Twin Cities]</orgName>
          <orgName type="acronym">UMN</orgName>
          <date type="start">1851-01-01</date>
          <desc>
            <address>
              <addrLine>Minneapolis, MN 55455</addrLine>
              <country key="US"/>
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            <ref type="url">https://twin-cities.umn.edu/</ref>
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          <listRelation>
            <relation active="#struct-566446" type="direct"/>
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        <org type="regroupinstitution" xml:id="struct-566446" status="VALID">
          <idno type="ISNI">0000 0004 0519 9645</idno>
          <idno type="ROR">https://ror.org/03grvy078</idno>
          <orgName>University of Minnesota System</orgName>
          <orgName type="acronym">UMN</orgName>
          <desc>
            <address>
              <country key="US"/>
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            <ref type="url">https://system.umn.edu/</ref>
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        <org type="institution" xml:id="struct-357061" status="INCOMING">
          <orgName>Abbott Northwestern Hospital</orgName>
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            <address>
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        </org>
        <org type="institution" xml:id="struct-303979" status="VALID">
          <idno type="ROR">https://ror.org/03gds6c39</idno>
          <orgName>The University of Texas Health Science Center at Houston</orgName>
          <orgName type="acronym">UTHealth</orgName>
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            <address>
              <addrLine>7000 Fannin, Suite 1200Houston, Texas 77030</addrLine>
              <country key="US"/>
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            <ref type="url">https://www.uth.edu/</ref>
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        </org>
        <org type="institution" xml:id="struct-146992" status="VALID">
          <idno type="ROR">https://ror.org/02crff812</idno>
          <orgName>Universität Zürich [Zürich] = University of Zurich</orgName>
          <orgName type="acronym">UZH</orgName>
          <desc>
            <address>
              <addrLine>Rämistrasse 71 CH-8006 Zürich</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">http://www.uzh.ch/de.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302049" status="OLD">
          <idno type="ROR">https://ror.org/01wep6g48</idno>
          <orgName>Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture</orgName>
          <orgName type="acronym">IRSTEA</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.irstea.fr</ref>
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        <org type="institution" xml:id="struct-485794" status="VALID">
          <idno type="IdRef">027648745</idno>
          <idno type="ISNI">0000000109414873</idno>
          <idno type="ROR">https://ror.org/03yj89h83</idno>
          <idno type="Wikidata">Q1357517</idno>
          <orgName>University of Oulu [Finland] = Oulun yliopisto [Suomi] = Université d'Oulu [Finlande]</orgName>
          <date type="start">1958-01-08</date>
          <desc>
            <address>
              <addrLine>Pentti Kaiteran katu 1 – Linnanmaa – Oulu – Suomi</addrLine>
              <country key="FI"/>
            </address>
            <ref type="url">https://www.oulu.fi</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-304544" status="VALID">
          <idno type="IdRef">032657439</idno>
          <orgName>Universität Ulm - Ulm University [Ulm, Allemagne]</orgName>
          <date type="start">1967-01-01</date>
          <desc>
            <address>
              <addrLine>Helmholtzstraße 16, 89081 Ulm</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uni-ulm.de/</ref>
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        </org>
        <org type="institution" xml:id="struct-447262" status="INCOMING">
          <orgName>Military Medical Academy [Serbia]</orgName>
          <desc>
            <address>
              <addrLine>Crnotravska 17, Beograd</addrLine>
              <country key="RS"/>
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          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1152891" status="VALID">
          <orgName>Pôle Cardiovasculaire et Métabolique [CHU Toulouse]</orgName>
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            <address>
              <addrLine>Toulouse</addrLine>
              <country key="FR"/>
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          </desc>
          <listRelation>
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        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.chu-toulouse.fr</ref>
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        </org>
        <org type="regrouplaboratory" xml:id="struct-574694" status="VALID">
          <orgName>Faculty of Health and Medical Sciences</orgName>
          <desc>
            <address>
              <addrLine>Blegdamsvej 3BDK-2200 Copenhagen NDenmark</addrLine>
              <country key="DK"/>
            </address>
            <ref type="url">https://healthsciences.ku.dk/</ref>
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          <idno type="ROR">https://ror.org/035b05819</idno>
          <orgName>Københavns Universitet = University of Copenhagen = Université de Copenhague</orgName>
          <orgName type="acronym">UCPH</orgName>
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          <desc>
            <address>
              <addrLine>Nørregade 10, 1165 København, Danemark</addrLine>
              <country key="DK"/>
            </address>
            <ref type="url">http://www.ku.dk</ref>
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        </org>
        <org type="institution" xml:id="struct-300851" status="VALID">
          <idno type="ROR">https://ror.org/05xvt9f17</idno>
          <orgName>Leiden University Medical Center [Leiden]</orgName>
          <orgName type="acronym">LUMC</orgName>
          <desc>
            <address>
              <addrLine>Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden</addrLine>
              <country key="NL"/>
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        </org>
        <org type="regroupinstitution" xml:id="struct-121723" status="VALID">
          <idno type="ROR">https://ror.org/027bh9e22</idno>
          <orgName>Universiteit Leiden = Leiden University</orgName>
          <desc>
            <address>
              <addrLine>Leiden University | 2300 RA Leiden The Netherlands</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.universiteitleiden.nl/en/</ref>
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        </org>
        <org type="institution" xml:id="struct-447266" status="VALID">
          <idno type="ROR">https://ror.org/00ey0ed83</idno>
          <orgName>Odense University Hospital</orgName>
          <orgName type="acronym">OUH</orgName>
          <desc>
            <address>
              <addrLine>J. B. Winsløws Vej 4, 5000 Odense, Danemark</addrLine>
              <country key="DK"/>
            </address>
            <ref type="url">https://en.ouh.dk/</ref>
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        <org type="institution" xml:id="struct-123876" status="VALID">
          <orgName>University of Debrecen</orgName>
          <desc>
            <address>
              <addrLine>Debrecen, Egyetem tér 1</addrLine>
              <country key="HU"/>
            </address>
            <ref type="url">http://www.unideb.hu/portal/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1175891" status="VALID">
          <orgName>George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures</orgName>
          <orgName type="acronym">UMFST</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>38 Gheorghe Marinescu Street, Targu Mureș, 540142</addrLine>
              <country key="RO"/>
            </address>
            <ref type="url">https://arhiva.umfst.ro/en/home.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-447273" status="INCOMING">
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            <address>
              <addrLine>Honvedelmi Miniszterium - Balaton u 7/11 - H-1055 Budapest</addrLine>
              <country key="HU"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-447274" status="INCOMING">
          <orgName>Ministry of Defence [Budapest]</orgName>
          <desc>
            <address>
              <addrLine>Honvedelmi Miniszterium - Balaton u 7/11 - H-1055 Budapest</addrLine>
              <country key="HU"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-336271" status="VALID">
          <orgName>Institute of Clinical Physiology</orgName>
          <orgName type="acronym">IFC</orgName>
          <date type="start">1967-01-01</date>
          <desc>
            <address>
              <addrLine>c/o Area di Ricerca "S. Cataldo"Via Giuseppe Moruzzi, 1 - 56124 Pisa (PI)</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.cnr.it/en/institute/035/institute-of-clinical-physiology-ifc</ref>
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        </org>
        <org type="regroupinstitution" xml:id="struct-254021" status="VALID">
          <idno type="ISNI">0000 0001 2159 6200</idno>
          <idno type="ROR">https://ror.org/04zaypm56</idno>
          <orgName>National Research Council of Italy | Consiglio Nazionale delle Ricerche</orgName>
          <orgName type="acronym">CNR</orgName>
          <date type="start">1923-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro, 7 - 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.cnr.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-335120" status="VALID">
          <orgName>Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]</orgName>
          <date type="start">1965-01-01</date>
          <desc>
            <address>
              <addrLine>Universitätsstr. 140225 Düsseldorf</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uni-duesseldorf.de</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-447278" status="INCOMING">
          <orgName>Division of Cardiology, Pulmonology and Vascular Medicine</orgName>
          <desc>
            <address>
              <addrLine>Moorenstraße 5, 40225 Düsseldorf</addrLine>
              <country key="DE"/>
            </address>
          </desc>
        </org>
      </listOrg>
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</TEI>