{"text_format":"2","workbook":"xlsx","n_sheets":1,"sheets":["Table S15"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Table S15","index":0,"n_rows":340,"n_cols":7,"rows_kept":340,"cut":false,"hidden":false,"merged":[]}
["pre-DAPPLE ASD input 336g","336g minus 151g (excluded 185g)","DAPPLE ASD direct PPI 151g","DAPPLE minus 54 known ASD genes (97g, high-confident ASD candidates)","DAPPLE known ASD genes only 54g","Functional group","NOTES"]
["ABCA1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["ABL1","-","Yes","Yes","-","MAPK & other signalling"]
["ACACB","Yes","-","-","-"]
["ACSL4","Yes","-","-","-"]
["ADAM33","Yes","-","-","-"]
["ADNP","Yes","-","-","-"]
["AFF2","-","Yes","-","Yes","MAPK & other signalling"]
["ANK2","-","Yes","Yes","-","MAPK & other signalling"]
["ANKRD11","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["ANKS1B","Yes","-","-","-"]
["ANO5","Yes","-","-","-"]
["AP1S2","Yes","-","-","-"]
["APH1A","Yes","-","-","-"]
["ARHGAP32","-","Yes","Yes","-","MAPK & other signalling"]
["ARHGDIA","-","Yes","Yes","-","MAPK & other signalling"]
["ARID1B","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["ARSF","Yes","-","-","-"]
["ARSH","Yes","-","-","-"]
["ARX","Yes","-","-","-"]
["ASAH2","Yes","-","-","-"]
["ATOH1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["ATP10D","Yes","-","-","-"]
["ATP1B1","-","Yes","Yes","-","MAPK & other signalling"]
["ATP1B4","Yes","-","-","-"]
["ATRX","Yes","-","-","-"]
["BAZ1B","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["BCL11A","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["BEND2","Yes","-","-","-"]
["BHLHE22","Yes","-","-","-"]
["BNC1","Yes","-","-","-"]
["BRAF","-","Yes","-","Yes","MAPK & other signalling"]
["BRMS1L","Yes","-","-","-"]
["BRWD1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["BTN1A1","Yes","-","-","-"]
["C20orf111","Yes","-","-","-"]
["CACNA1B","-","Yes","Yes","-","Neuronal development and axon guidance"]
["CACNA1C","-","Yes","-","Yes","Neuronal development and axon guidance"]
["CACNA1F","-","Yes","-","Yes","Neuronal development and axon guidance"]
["CACNA2D3","Yes","-","-","-"]
["CAMK2G","-","Yes","Yes","-","Neuronal development and axon guidance"]
["CASK","-","Yes","-","Yes","Neuronal development and axon guidance"]
["CBS","Yes","-","-","-"]
["CBX4","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["CDC42BPB","Yes","-","-","-"]
["CDK2","-","Yes","Yes","-"]
["CDK4","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["CDKL5","-","Yes","-","Yes","Neuronal development and axon guidance"]
["CEP70","Yes","-","-","-"]
["CHD1L","Yes","-","-","-"]
["CHD2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["CHD7","Yes","-","-","-"]
["CHD8","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["CHRNA7","Yes","-","-","-"]
["CNOT3","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["COL25A1","Yes","-","-","-"]
["CREBBP","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["CRKL","-","Yes","Yes","-","MAPK & other signalling"]
["CSDE1","-","Yes","Yes","-","MAPK & other signalling"]
["CSNK1D","Yes","-","-","-"]
["CSTF2T","Yes","-","-","-"]
["CT45A5","Yes","-","-","-"]
["CTTNBP2","Yes","-","-","-"]
["CUBN","-","Yes","Yes","-","not assigned"]
["CUL2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["CUL3","-","Yes","Yes","-","not assigned"]
["CUTA","Yes","-","-","-"]
["CXCR3","Yes","-","-","-"]
["CYFIP1","-","Yes","Yes","-","Neuronal development and axon guidance"]
["CYP7B1","Yes","-","-","-"]
["DBI","Yes","-","-","-"]
["DBT","Yes","-","-","-"]
["DCX","-","Yes","-","Yes","Neuronal development and axon guidance"]
["DDX53","Yes","-","-","-"]
["DGAT2L6","Yes","-","-","-"]
["DHRS4L1","-","-","-","-",null,"Not recognized by DAPPLE"]
["DIP2A","Yes","-","-","-"]
["DIP2C","Yes","-","-","-"]
["DLGAP2","-","Yes","Yes","-","Neuronal development and axon guidance"]
["DLL1","-","Yes","Yes","-","not assigned"]
["DMD","-","Yes","-","Yes","Neuronal development and axon guidance"]
["DMPK","Yes","-","-","-"]
["DNAH5","Yes","-","-","-"]
["DPP6","Yes","-","-","-"]
["DRP2","-","Yes","Yes","-","Neuronal development and axon guidance"]
["DST","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["DTNA","-","Yes","Yes","-","Neuronal development and axon guidance"]
["DYRK1A","-","Yes","-","Yes","MAPK & other signalling"]
["ECM2","Yes","-","-","-"]
["EFCAB5","Yes","-","-","-"]
["EHMT1","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["EPHB2","-","Yes","Yes","-","MAPK & other signalling"]
["ERCC6","-","Yes","Yes","-","not assigned"]
["ESR2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["ETFB","Yes","-","-","-"]
["ETS1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["FAM8A1","Yes","-","-","-"]
["FAM91A1","Yes","-","-","-"]
["FCRL6","Yes","-","-","-"]
["FGD1","Yes","-","-","-"]
["FGFR2","-","Yes","-","Yes","MAPK & other signalling"]
["FLG","Yes","-","-","-"]
["FLNA","-","Yes","Yes","-","Neuronal development and axon guidance"]
["FMR1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["FOXG1","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["FOXP1","Yes","-","-","-"]
["FREM3","Yes","-","-","-"]
["FTSJ1","-","Yes","-","Yes","MAPK & other signalling"]
["GALNTL4","Yes","-","-","-"]
["GALR1","Yes","-","-","-"]
["GARNL1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["GIMAP8","Yes","-","-","-"]
["GPR112","Yes","-","-","-"]
["GRIA3","Yes","-","-","-"]
["GRID2","Yes","-","-","-"]
["GRIN2B","-","Yes","-","Yes","MAPK & other signalling"]
["GYG2","Yes","-","-","-"]
["HAUS7","-","Yes","Yes","-","not assigned"]
["HEPACAM","Yes","-","-","-"]
["HRAS","-","Yes","-","Yes","MAPK & other signalling"]
["HSD17B10","Yes","-","-","-"]
["IGF2","Yes","-","-","-"]
["IKBKG","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["IL1RAPL1","-","Yes","-","Yes","MAPK & other signalling"]
["IL1RL1","Yes","-","-","-"]
["IQGAP2","-","Yes","Yes","-","MAPK & other signalling"]
["IQSEC2","Yes","-","-","-"]
["ITGA5","-","Yes","Yes","-","MAPK & other signalling"]
["ITIH5L","Yes","-","-","-"]
["KAT2B","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["KATNAL2","Yes","-","-","-"]
["KCNH8","Yes","-","-","-"]
["KCNJ11","Yes","-","-","-"]
["KDM5C","Yes","-","-","-"]
["KDM6A","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["KDM6B","Yes","-","-","-"]
["KIAA0100","Yes","-","-","-"]
["KIAA0232","-","Yes","Yes","-","Neuronal development and axon guidance"]
["KIAA1210","Yes","-","-","-"]
["KIAA2022","Yes","-","-","-"]
["KLF13","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["KRAS","-","Yes","-","Yes","MAPK & other signalling"]
["L1CAM","-","Yes","-","Yes","MAPK & other signalling"]
["LAMP2","Yes","-","-","-"]
["LARGE","Yes","-","-","-"]
["LIMK1","-","Yes","Yes","-","MAPK & other signalling"]
["LMTK3","Yes","-","-","-"]
["LRP2","-","Yes","Yes","-","not assigned"]
["LSAMP","Yes","-","-","-"]
["LUZP4","Yes","-","-","-"]
["MAGEC3","Yes","-","-","-"]
["MAP2K1","-","Yes","-","Yes","MAPK & other signalling"]
["MAPK11","-","Yes","Yes","-","MAPK & other signalling"]
["MAPK12","-","Yes","Yes","-","MAPK & other signalling"]
["MAPK3","-","Yes","Yes","-","MAPK & other signalling"]
["MAPK7","-","Yes","Yes","-","MAPK & other signalling"]
["MAPK8","-","Yes","Yes","-","MAPK & other signalling"]
["MAX","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["MBD5","Yes","-","-","-"]
["MCF2","-","Yes","Yes","-","MAPK & other signalling"]
["MDM2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["MECP2","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["MED12","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["MED13L","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["MEF2C","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["MFRP","Yes","-","-","-"]
["MID1","Yes","-","-","-"]
["MLL3","Yes","-","-","-"]
["MLL5","Yes","-","-","-"]
["MPHOSPH8","Yes","-","-","-"]
["MSI2","Yes","-","-","-"]
["MTHFS","Yes","-","-","-"]
["MTMR12","Yes","-","-","-"]
["MTMR8","Yes","-","-","-"]
["NAPRT1","Yes","-","-","-"]
["NCKAP1","-","Yes","Yes","-","Neuronal development and axon guidance"]
["NDP","Yes","-","-","-"]
["NF1","-","Yes","-","Yes","MAPK & other signalling"]
["NFIA","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["NFIX","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["NHS","Yes","-","-","-"]
["NIPBL","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["NLGN3","-","Yes","-","Yes","Neuronal development and axon guidance"]
["NLGN4X","-","Yes","-","Yes","Neuronal development and axon guidance"]
["NR3C2","Yes","-","-","-"]
["NRXN1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["NRXN3","-","Yes","Yes","-","Neuronal development and axon guidance"]
["NSD1","Yes","-","-","-"]
["NTSR2","Yes","-","-","-"]
["NUAK1","Yes","-","-","-"]
["OCRL","-","Yes","-","Yes","not assigned"]
["OPHN1","Yes","-","-","-"]
["OTC","Yes","-","-","-"]
["PAFAH1B1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["PARD3","-","Yes","Yes","-","Neuronal development and axon guidance"]
["PARK2","-","Yes","Yes","-","Neuronal development and axon guidance"]
["PAX5","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["PCDH11X","Yes","-","-","-"]
["PCDH19","Yes","-","-","-"]
["PCDHA13","-","-","-","-",null,"Not recognized by DAPPLE"]
["PCOLCE","Yes","-","-","-"]
["PCYT1A","Yes","-","-","-"]
["PDCD1","Yes","-","-","-"]
["PHF2","Yes","-","-","-"]
["PHF6","Yes","-","-","-"]
["PHF8","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["PIK3CB","-","Yes","Yes","-","MAPK & other signalling"]
["PIR","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["PLCB1","-","Yes","Yes","-","Neuronal development and axon guidance"]
["PLXNB1","Yes","-","-","-"]
["PMPCB","Yes","-","-","-"]
["POGZ","Yes","-","-","-"]
["POLRMT","Yes","-","-","-"]
["PPM1D","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["PPP1R15B","Yes","-","-","-"]
["PPP3CB","-","Yes","Yes","-","Neuronal development and axon guidance"]
["PQBP1","Yes","-","-","-"]
["PRDX4","Yes","-","-","-"]
["PRKAB2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["PRPF39","Yes","-","-","-"]
["PSMB1","-","Yes","Yes","-","MAPK & other signalling"]
["PSMC2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["PTCHD1","Yes","-","-","-"]
["PTEN","-","Yes","-","Yes","MAPK & other signalling"]
["PTPN11","-","Yes","-","Yes","MAPK & other signalling"]
["PTPRD","-","Yes","Yes","-","not assigned"]
["RAB2A","Yes","-","-","-"]
["RAB39B","Yes","-","-","-"]
["RAB5A","-","Yes","Yes","-","MAPK & other signalling"]
["RABGGTA","Yes","-","-","-"]
["RAC3","-","Yes","Yes","-","MAPK & other signalling"]
["RAD21L1","-","-","-","-",null,"Not recognized by DAPPLE"]
["RAI1","Yes","-","-","-"]
["RAP1GDS1","-","Yes","Yes","-","MAPK & other signalling"]
["RELN","Yes","-","-","-"]
["RER1","-","Yes","Yes","-","MAPK & other signalling"]
["RFX3","Yes","-","-","-"]
["RIMS1","-","Yes","Yes","-","Neuronal development and axon guidance"]
["RNASE1","Yes","-","-","-"]
["RNASE6","Yes","-","-","-"]
["RNF128","Yes","-","-","-"]
["RNF135","Yes","-","-","-"]
["RNF160","Yes","-","-","-"]
["RNF38","Yes","-","-","-"]
["RPL19","Yes","-","-","-"]
["RPS6KA3","-","Yes","Yes","-","Neuronal development and axon guidance"]
["RTCD1","Yes","-","-","-"]
["SATB2","Yes","-","-","-"]
["SCAND2","Yes","-","-","-"]
["SCAPER","Yes","-","-","-"]
["SCN1A","-","Yes","-","Yes","not assigned"]
["SCN2A","-","Yes","-","Yes","not assigned"]
["SCN8A","Yes","-","-","-"]
["SCP2","Yes","-","-","-"]
["SCUBE2","Yes","-","-","-"]
["SETBP1","Yes","-","-","-"]
["SETD2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["SETD5","Yes","-","-","-"]
["SH3GL3","-","Yes","Yes","-","Neuronal development and axon guidance"]
["SHANK2","-","Yes","-","Yes","Neuronal development and axon guidance"]
["SHANK3","-","Yes","-","Yes","Neuronal development and axon guidance"]
["SKI","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["SLC25A39","Yes","-","-","-"]
["SLC6A8","Yes","-","-","-"]
["SLC7A7","Yes","-","-","-"]
["SLC9A6","Yes","-","-","-"]
["SMAD4","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["SMAP1","Yes","-","-","-"]
["SMARCA2","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["SMARCC2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["SMC1A","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["SMC2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["SNRPN","-","Yes","Yes","-","Neuronal development and axon guidance"]
["SNX14","Yes","-","-","-"]
["SNX9","-","Yes","Yes","-","not assigned"]
["SOD2","-","Yes","Yes","-","MAPK & other signalling"]
["SPAST","-","Yes","Yes","-","MAPK & other signalling"]
["SPATA13","-","Yes","Yes","-"]
["SPP2","Yes","-","-","-"]
["SPRED1","Yes","-","-","-"]
["SRCAP","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["SREBF1","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["SRPX2","Yes","-","-","-"]
["ST3GAL6","Yes","-","-","-"]
["STAC2","Yes","-","-","-"]
["STAU2","-","Yes","Yes","-","not assigned"]
["STEAP3","Yes","-","-","-"]
["STXBP1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["SUCLA2","Yes","-","-","-"]
["SUV420H1","Yes","-","-","-"]
["SVIL","-","Yes","Yes","-","MAPK & other signalling"]
["SYN1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["SYNCRIP","-","Yes","Yes","-","MAPK & other signalling"]
["SYNGAP1","-","Yes","-","Yes","Neuronal development and axon guidance"]
["SYNJ2","-","Yes","Yes","-","Neuronal development and axon guidance"]
["TAOK2","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["TBC1D23","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["TBP","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["TBR1","-","Yes","Yes","-","Neuronal development and axon guidance"]
["TBX18","Yes","-","-","-"]
["TCF3","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["TCF4","Yes","-","-","-"]
["THSD7A","Yes","-","-","-"]
["TICAM1","Yes","-","-","-"]
["TM4SF19","Yes","-","-","-"]
["TMLHE","Yes","-","-","-"]
["TNK2","-","Yes","Yes","-","MAPK & other signalling"]
["TRIM17","Yes","-","-","-"]
["TRIP12","Yes","-","-","-"]
["TROVE2","Yes","-","-","-"]
["TRPM5","Yes","-","-","-"]
["TSC1","-","Yes","-","Yes","MAPK & other signalling"]
["TSC2","-","Yes","-","Yes","MAPK & other signalling"]
["TSPAN17","Yes","-","-","-"]
["TSSK2","Yes","-","-","-"]
["TUBGCP4","Yes","-","-","-"]
["TUBGCP5","Yes","-","-","-"]
["UBE2W","Yes","-","-","-"]
["UBE3A","Yes","-","-","-"]
["UBN2","Yes","-","-","-"]
["UBR3","Yes","-","-","-"]
["UHRF1","Yes","-","-","-"]
["UNC80","Yes","-","-","-"]
["UPF3B","-","Yes","-","Yes","Chromatin modification & Transcription regulation"]
["USP15","Yes","-","-","-"]
["VCP","-","Yes","Yes","-","MAPK & other signalling"]
["VSIG1","Yes","-","-","-"]
["WDFY3","Yes","-","-","-"]
["WDR4","Yes","-","-","-"]
["WTAP","Yes","-","-","-"]
["YWHAE","-","Yes","-","Yes","MAPK & other signalling"]
["ZCCHC13","Yes","-","-","-"]
["ZCCHC16","Yes","-","-","-"]
["ZEB2","Yes","-","-","-"]
["ZFYVE26","Yes","-","-","-"]
["ZMYND11","-","Yes","Yes","-","Chromatin modification & Transcription regulation"]
["ZNF157","Yes","-","-","-"]
["ZNF292","-","Yes","Yes","-","Neuronal development and axon guidance"]
["ZNF516","Yes","-","-","-"]
["ZSCAN2","Yes","-","-","-"]