%0 Journal Article %T Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort. %+ Epidémiologie et Biostatistique [Bordeaux] %+ Service d'information médicale %+ Service d'immunologie et d'immunogénétique [Bordeaux] %+ Service de médecine interne et maladies infectieuses %+ Microbiologie Fondamentale et Pathogénicité (MFP) %+ Composantes innées de la réponse immunitaire et différenciation (CIRID) %A Wittkop, Linda, Dr %A Bitard, Juliette %A Lazaro, Estibaliz %A Neau, Didier %A Bonnet, Fabrice %A Mercie, Patrick %A Dupon, Michel %A Hessamfar, Mojgan %A Ventura, Michel %A Malvy, Denis %A Dabis, François %A Pellegrin, Jean-Luc %A Moreau, Jean-François %A Thiébaut, Rodolphe %A Pellegrin, Isabelle %< avec comité de lecture %@ 0022-1899 %J Journal of Infectious Diseases %I Oxford University Press (OUP) %V 207 %N 4 %P 622-7 %8 2013-02-15 %D 2013 %R 10.1093/infdis/jis732 %M 23204178 %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseases %Z Life Sciences [q-bio]/ImmunologyJournal articles %X We evaluated the impact of cytomegalovirus (CMV)-induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1-infected patients from the ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt of combination antiretroviral therapy (cART). HLA-DR(+)/CD38(+) expression was 16.8% among CD8(+) T cells. Independent of age, CD4(+) T-cell count, 16S ribosomal DNA load, and regulatory T-cell count, positive results of Quantiferon CMV analysis (P = .02), positive results of CMV-pp65 enzyme-linked immunosorbent spot analysis (P = .01), positive results of CMV-pp65-specific CD8(+) T-cell analysis (P = .05), and CMV seropositivity (P = .01) were associated with a higher percentage of CD8+ T cells that expressed HLA-DR+/CD38+. Autoimmune response and microbial translocation were not associated with immune activation. Therefore, the CMV-induced immune response seems to be associated with chronic immune activation in cART recipients with sustained virological suppression. %G English %Z Groupe d'Epidémiologie Clinique du SIDA en Aquitaine %L inserm-00936482 %U https://inserm.hal.science/inserm-00936482 %~ INSERM %~ CNRS %~ SANTE_PUB_INSERM %~ ANRSCO3