Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.
Mirko Manchia
(1)
,
Mazda Adli
(2)
,
Nirmala Akula
(3)
,
Raffaella Ardau
(4)
,
Jean-Michel Aubry
(5)
,
Lena Backlund
(6)
,
Claudio Em Banzato
(7)
,
Bernhard T. Baune
(8)
,
Frank Bellivier
(9)
,
Susanne Bengesser
(10)
,
Joanna M. Biernacka
(11)
,
Clara Brichant-Petitjean
(9)
,
Elise Bui
(3)
,
Cynthia V. Calkin
(1)
,
Andrew Tai Ann Cheng
(12)
,
Caterina Chillotti
(4)
,
Sven Cichon
(13)
,
Scott Clark
(8)
,
Piotr M. Czerski
(14)
,
Clarissa Dantas
(7)
,
Maria Del Zompo
(4, 15)
,
J Raymond Depaulo
(16)
,
Sevilla D. Detera-Wadleigh
(3)
,
Bruno Etain
(17)
,
Peter Falkai
(18)
,
Louise Frisén
(6)
,
Mark A. Frye
(11)
,
Jan Fullerton
(19)
,
Sébastien Gard
(20)
,
Julie Garnham
(1)
,
Fernando S. Goes
(16)
,
Paul Grof
(21, 22)
,
Oliver Gruber
(23)
,
Ryota Hashimoto
(24)
,
Joanna Hauser
(14)
,
Urs Heilbronner
(23)
,
Rebecca Hoban
(25, 26)
,
Liping Hou
(3)
,
Stéphane Jamain
(17)
,
Jean-Pierre Kahn
(27)
,
Layla Kassem
(3)
,
Tadafumi Kato
(28)
,
John R. Kelsoe
(25, 26)
,
Sarah Kittel-Schneider
(29)
,
Sebastian Kliwicki
(30)
,
Po-Hsiu Kuo
(31)
,
Ichiro Kusumi
(32, 28)
,
Gonzalo Laje
(3)
,
Catharina Lavebratt
(33, 34)
,
Marion Leboyer
(17)
,
Susan G. Leckband
(25, 35, 36)
,
Carlos A. López Jaramillo
(37)
,
Mario Maj
(38)
,
Alain Malafosse
(5)
,
Lina Martinsson
(6)
,
Takuya Masui
(32)
,
Philip B. Mitchell
(39)
,
Frank Mondimore
(16)
,
Palmiero Monteleone
(38)
,
Audrey Nallet
(5)
,
Maria Neuner
(29)
,
Tomás Novák
(40)
,
Claire O'Donovan
(1)
,
Urban Osby
(33, 34)
,
Norio Ozaki
(41, 42)
,
Roy H. Perlis
(43)
,
Andrea Pfennig
(44)
,
James B. Potash
(16, 45)
,
Daniela Reich-Erkelenz
(23)
,
Andreas Reif
(29)
,
Eva Reininghaus
(10)
,
Sara Richardson
(3)
,
Guy A. Rouleau
(46, 47)
,
Janusz K. Rybakowski
(30)
,
Martin Schalling
(33, 34)
,
Peter R. Schofield
(19)
,
Oliver K. Schubert
(8)
,
Barbara Schweizer
(16)
,
Florian Seemüller
(18)
,
Maria Grigoroiu-Serbanescu
(48)
,
Giovanni Severino
(15)
,
Lisa R. Seymour
(11)
,
Claire Slaney
(1)
,
Jordan W. Smoller
(43)
,
Alessio Squassina
(15)
,
Thomas Stamm
(2)
,
Jo Steele
(3)
,
Pavla Stopkova
(40)
,
Sarah K. Tighe
(16)
,
Alfonso Tortorella
(38)
,
Gustavo Turecki
(49)
,
Naomi R. Wray
(50)
,
Adam Wright
(39)
,
Peter P. Zandi
(51)
,
David Zilles
(23)
,
Michael Bauer
(44)
,
Marcella Rietschel
(52)
,
Francis J. Mcmahon
(3)
,
Thomas G. Schulze
(3, 16, 23, 52)
,
Martin Alda
(1)
1
Department of Psychiatry
2 Department of Psychiatry and Psychotherapy
3 Human Genetics Branch
4 Unit of Clinical Pharmacology
5 Department of Mental Health and Psychiatry
6 Department of Psychiatry
7 Department of Psychiatry
8 Department of Psychiatry
9 Pôle de Psychiatrie
10 Department of Psychiatry
11 Department of Psychiatry
12 Division of Epidemiology and Genetics
13 Department of Genomics, Life and Brain Center
14 Psychiatric Genetic Unit
15 Section of Neuroscience and Clinical Pharmacology
16 Department of Psychiatry and Behavioral Sciences
17 IMRB - Institut Mondor de Recherche Biomédicale
18 Department of Psychiatry and Psychotherapy
19 Genetics of Mental Illness and Brain Function
20 Service de psychiatrie adulte
21 MDCO - Mood Disorders Center of Ottawa
22 Department of Psychiatry
23 Department of Psychiatry and Psychotherapy
24 Osaka University Graduate School of Medicine
25 Department of Psychiatry
26 Department of Psychiatry
27 Service de Psychiatrie et Psychologie Clinique
28 Laboratory for Molecular Dynamics of Mental Disorders
29 Mental Health Sciences Unit
30 Department of Adult Psychiatry
31 Institute of Epidemiology and Preventive Medicine
32 Department of Psychiatry
33 Molecular Medicine and Surgery department
34 Center for Molecular Medicine
35 Department of Pharmacy
36 Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego]
37 Department of Psychiatry
38 Department of Psychiatry
39 School of Psychiatry
40 Prague Psychiatric Center
41 Department of Psychiatry
42 Department of Psychiatry
43 Department of Psychiatry
44 Department of Psychiatry and Psychotherapy
45 Department of Psychiatry
46 Center of Excellence in Neuroscience
47 Department of Medicine
48 Biometric Psychiatric Genetics Research Unit
49 MGSS - McGill Group for Suicide Studies
50 Queensland Brain Institute
51 Department of Mental Health
52 Department of Genetic Epidemiology in Psychiatry [Mannhein]
2 Department of Psychiatry and Psychotherapy
3 Human Genetics Branch
4 Unit of Clinical Pharmacology
5 Department of Mental Health and Psychiatry
6 Department of Psychiatry
7 Department of Psychiatry
8 Department of Psychiatry
9 Pôle de Psychiatrie
10 Department of Psychiatry
11 Department of Psychiatry
12 Division of Epidemiology and Genetics
13 Department of Genomics, Life and Brain Center
14 Psychiatric Genetic Unit
15 Section of Neuroscience and Clinical Pharmacology
16 Department of Psychiatry and Behavioral Sciences
17 IMRB - Institut Mondor de Recherche Biomédicale
18 Department of Psychiatry and Psychotherapy
19 Genetics of Mental Illness and Brain Function
20 Service de psychiatrie adulte
21 MDCO - Mood Disorders Center of Ottawa
22 Department of Psychiatry
23 Department of Psychiatry and Psychotherapy
24 Osaka University Graduate School of Medicine
25 Department of Psychiatry
26 Department of Psychiatry
27 Service de Psychiatrie et Psychologie Clinique
28 Laboratory for Molecular Dynamics of Mental Disorders
29 Mental Health Sciences Unit
30 Department of Adult Psychiatry
31 Institute of Epidemiology and Preventive Medicine
32 Department of Psychiatry
33 Molecular Medicine and Surgery department
34 Center for Molecular Medicine
35 Department of Pharmacy
36 Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego]
37 Department of Psychiatry
38 Department of Psychiatry
39 School of Psychiatry
40 Prague Psychiatric Center
41 Department of Psychiatry
42 Department of Psychiatry
43 Department of Psychiatry
44 Department of Psychiatry and Psychotherapy
45 Department of Psychiatry
46 Center of Excellence in Neuroscience
47 Department of Medicine
48 Biometric Psychiatric Genetics Research Unit
49 MGSS - McGill Group for Suicide Studies
50 Queensland Brain Institute
51 Department of Mental Health
52 Department of Genetic Epidemiology in Psychiatry [Mannhein]
Frank Bellivier
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Scott Clark
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Bruno Etain
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Julie Garnham
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Joanna Hauser
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Urs Heilbronner
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Stéphane Jamain
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Ichiro Kusumi
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- ORCID : 0000-0002-8747-5070
Catharina Lavebratt
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- ORCID : 0000-0003-4987-2718
Marion Leboyer
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Urban Osby
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Norio Ozaki
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Andreas Reif
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Maria Grigoroiu-Serbanescu
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Giovanni Severino
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Alessio Squassina
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Gustavo Turecki
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- PersonId : 769354
- ORCID : 0000-0003-4075-2736
Michael Bauer
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- PersonId : 765030
- ORCID : 0000-0002-2666-859X
Marcella Rietschel
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- PersonId : 757743
- ORCID : 0000-0002-5236-6149
Martin Alda
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Résumé
OBJECTIVE: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. MATERIALS AND METHODS: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. RESULTS: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). CONCLUSIONS: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.
Domaines
Biochimie, Biologie MoléculaireOrigine | Fichiers éditeurs autorisés sur une archive ouverte |
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