<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-00826675</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T00:52:37+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Follistatin Is an Early Player in Rainbow Trout Ovarian Differentiation and Is Both Colocalized with Aromatase and Regulated by the Wnt Pathway.</title>
            <author role="aut">
              <persName>
                <forename type="first">Barbara</forename>
                <surname>Nicol</surname>
              </persName>
              <idno type="halauthorid">446855-0</idno>
              <affiliation ref="#struct-187317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ayaka</forename>
                <surname>Yano</surname>
              </persName>
              <idno type="halauthorid">844624-0</idno>
              <affiliation ref="#struct-187317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elodie</forename>
                <surname>Jouanno</surname>
              </persName>
              <email type="md5">ea7bc28bdeaf90b66dc56d712c74edec</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">elodiejouanno</idno>
              <idno type="idhal" notation="numeric">740791</idno>
              <idno type="halauthorid" notation="string">18182-740791</idno>
              <idno type="IDREF">https://www.idref.fr/253131642</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-187317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adèle</forename>
                <surname>Guérin</surname>
              </persName>
              <email type="md5">057627e61681f29d38b1c7005e1a4f33</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">adele-branthonne</idno>
              <idno type="idhal" notation="numeric">743276</idno>
              <idno type="halauthorid" notation="string">393016-743276</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-187317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexis</forename>
                <surname>Fostier</surname>
              </persName>
              <idno type="halauthorid">1229606-0</idno>
              <affiliation ref="#struct-187317"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Yann</forename>
                <surname>Guiguen</surname>
              </persName>
              <email type="md5">671d4652646be68fad4967d3cc60841a</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">yann-guiguen</idno>
              <idno type="idhal" notation="numeric">739883</idno>
              <idno type="halauthorid" notation="string">5637-739883</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5464-6219</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=z475haIAAAAJ</idno>
              <idno type="IDREF">https://www.idref.fr/094996423</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-187317"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Clémence</forename>
                <surname>Martin</surname>
              </persName>
              <email type="md5">a0dd5305d662c72b3625e101b21eba55</email>
              <email type="domain">univ-rennes1.fr</email>
            </editor>
            <funder ref="#projeurop-19421"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-05-28 10:49:58</date>
              <date type="whenModified">2025-03-21 15:12:20</date>
              <date type="whenReleased">2013-05-28 14:36:01</date>
              <date type="whenProduced">2013-04-24</date>
              <fs>
                <f name="inra_etatDocument_local" notation="numeric">
                  <numeric>0</numeric>
                </f>
                <f name="inra_etatDocument_local" notation="string" n="0">
                  <string>inra_etatDocument_local_0</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="181807">
                <persName>
                  <forename>Clémence</forename>
                  <surname>Martin</surname>
                </persName>
                <email type="md5">a0dd5305d662c72b3625e101b21eba55</email>
                <email type="domain">univ-rennes1.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00826675</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-00826675</idno>
            <idno type="halBibtex">nicol:inserm-00826675</idno>
            <idno type="halRefHtml">&lt;i&gt;Sexual Development&lt;/i&gt;, 2013, 7 (5), epub ahead of print. &lt;a target="_blank" href="https://dx.doi.org/10.1159/000350687"&gt;&amp;#x27E8;10.1159/000350687&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Sexual Development, 2013, 7 (5), epub ahead of print. &amp;#x27E8;10.1159/000350687&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="LPGP"> Laboratoire de Physiologie et Génomique des Poissons Inra UR 1037</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="TEST-UNIV-RENNES">TEST Université de Rennes</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="PHASE">Physiologie animale et systèmes d’élevage</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Follistatin Is an Early Player in Rainbow Trout Ovarian Differentiation and Is Both Colocalized with Aromatase and Regulated by the Wnt Pathway.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Barbara</forename>
                    <surname>Nicol</surname>
                  </persName>
                  <idno type="halauthorid">446855-0</idno>
                  <affiliation ref="#struct-187317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ayaka</forename>
                    <surname>Yano</surname>
                  </persName>
                  <idno type="halauthorid">844624-0</idno>
                  <affiliation ref="#struct-187317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elodie</forename>
                    <surname>Jouanno</surname>
                  </persName>
                  <email type="md5">ea7bc28bdeaf90b66dc56d712c74edec</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">elodiejouanno</idno>
                  <idno type="idhal" notation="numeric">740791</idno>
                  <idno type="halauthorid" notation="string">18182-740791</idno>
                  <idno type="IDREF">https://www.idref.fr/253131642</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-187317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adèle</forename>
                    <surname>Guérin</surname>
                  </persName>
                  <email type="md5">057627e61681f29d38b1c7005e1a4f33</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">adele-branthonne</idno>
                  <idno type="idhal" notation="numeric">743276</idno>
                  <idno type="halauthorid" notation="string">393016-743276</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-187317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexis</forename>
                    <surname>Fostier</surname>
                  </persName>
                  <idno type="halauthorid">1229606-0</idno>
                  <affiliation ref="#struct-187317"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Yann</forename>
                    <surname>Guiguen</surname>
                  </persName>
                  <email type="md5">671d4652646be68fad4967d3cc60841a</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">yann-guiguen</idno>
                  <idno type="idhal" notation="numeric">739883</idno>
                  <idno type="halauthorid" notation="string">5637-739883</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5464-6219</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=z475haIAAAAJ</idno>
                  <idno type="IDREF">https://www.idref.fr/094996423</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-187317"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18927</idno>
                <idno type="issn">1661-5425</idno>
                <idno type="eissn">1661-5433</idno>
                <title level="j">Sexual Development</title>
                <imprint>
                  <publisher>Karger</publisher>
                  <biblScope unit="volume">7</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">epub ahead of print</biblScope>
                  <date type="datePub">2013-04-24</date>
                  <date type="dateEpub">2013-04-24</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1159/000350687</idno>
              <idno type="prodinra">189672</idno>
              <idno type="pubmed">23615022</idno>
              <idno type="wos">000321464700006</idno>
              <ref target="https://www.karger.com/Journal/Home/231547" type="seeAlso"/>
              <ref type="publisher">https://www.karger.com/Journal/Home/231547</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">teleost fish</term>
                <term xml:lang="en">rainbow trout</term>
                <term xml:lang="en">sex differentiation</term>
                <term xml:lang="en">wnt signaling</term>
                <term xml:lang="fr">follistatin</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bdlr">Life Sciences [q-bio]/Reproductive Biology</classCode>
              <classCode scheme="vocinrae-old" n="oncorhynchus mykiss">oncorhynchus mykiss</classCode>
              <classCode scheme="vocinrae-old" n="ovaire">ovaire</classCode>
              <classCode scheme="vocinrae-old" n="ovogenèse">ovogenèse</classCode>
              <classCode scheme="vocinrae-old" n="reproduction">reproduction</classCode>
              <classCode scheme="vocinrae-old" n="voie signalétique wnt">voie signalétique wnt</classCode>
              <classCode scheme="vocinrae-old" n="gonade">gonade</classCode>
              <classCode scheme="vocinrae-old" n="poisson">poisson</classCode>
              <classCode scheme="vocinrae-old" n="salmonidae">salmonidae</classCode>
              <classCode scheme="vocinrae-old" n="truite arc en ciel">truite arc en ciel</classCode>
              <classCode scheme="vocinrae-old" n="gène cyp 19">gène cyp 19</classCode>
              <classCode scheme="vocinrae-old" n="aromatase">aromatase</classCode>
              <classCode scheme="vocinrae-old" n="différenciation sexuelle">différenciation sexuelle</classCode>
              <classCode scheme="vocinrae-old" n="expression des gènes">expression des gènes</classCode>
              <classCode scheme="vocinrae-old" n="follistatine">follistatine</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In mammals, follistatin (FST) plays an important role in early ovarian differentiation, acting downstream of the Wnt pathway. In teleost fish, fst is implicated in folliculogenesis and oocyte maturation, and an early and specific expression during ovarian differentiation has been described in rainbow trout, Oncorhynchus mykiss. By in situ hybridization, we demonstrated that during rainbow trout gonadal differentiation, fst shares a similar expression pattern with cyp19a1a, the gene encoding ovarian aromatase, a key steroidogenic enzyme needed for ovarian differentiation in fish. Expression of fst and cyp19a1a was first detected in a few scattered cells in the embryonic ovary several days before hatching. Then, after histological differentiation, fst and cyp19a1a expression was localized in clusters of cells lining the future ovarian lamellae. As FST expression is known to be induced by the Wnt/β-catenin pathway in mammals, the Wnt pathway was inhibited in vivo with the IWR-1 molecule, and we analyzed by qPCR the effects of this treatment on fst expression. We found that IWR-1 decreased fst expression in female gonads, consistent with a regulation of fst expression by the Wnt pathway in rainbow trout. Furthermore, expression of cyp19a1a was also downregulated, suggesting an implication of the Wnt pathway in ovarian differentiation.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-187317" status="OLD">
          <orgName>Laboratoire de Physiologie et Génomique des Poissons</orgName>
          <orgName type="acronym">LPGP</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu - Bât. 16A - 35042 RENNES Cedex [France]</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.rennes.inra.fr/lpgp</ref>
          </desc>
          <listRelation>
            <relation name="UR1037" active="#struct-92114" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="europeanProject" xml:id="projeurop-19421" status="VALID">
          <idno type="number">222719</idno>
          <idno type="program">FP7-KBBE-2007-2A</idno>
          <idno type="call">FP7-KBBE-2007-2A</idno>
          <orgName>LIFECYCLE</orgName>
          <desc>Building a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture</desc>
          <date type="start">2009-01-02</date>
          <date type="end">2013-07-31</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>