%0 Journal Article %T [Angiotensin-2 type 1 receptors (AT1R) and cancers]. %+ Service de néphrologie [Rennes] %+ Institut de Génétique et Développement de Rennes (IGDR) %+ Service d'urologie [Rennes] = Urology [Rennes] %+ Cancer du rein : bases moléculaires de la tumorogenèse %+ Service de Pharmacologie [Rennes] %+ Cancer du rein : bases moléculaires de la tumorogenèse %+ Cancer du rein : bases moléculaires de la tumorogenèse %A Dolley-Hitze, Thibault %A Verhoest, Grégory %A Jouan, Florence %A Le Pogamp, Patrick %A Arlot-Bonnemains, Yannick %A Oger, Emmanuel %A Belaud-Rotureau, Marc-Antoine %A Rioux-Leclercq, Nathalie %A Vigneau, Cécile %Z région Bretagne ; l'université Rennes-1 ; l'Association française d'urologie (AFU) ; laboratoire Pfizer %< avec comité de lecture %@ 1769-7255 %J Néphrologie & Thérapeutique %I Elsevier Masson (jusqu'en 2022) / John Libbey Eurotext (à partir de 2023) %V 9 %N 2 %P 85-91 %8 2013-04 %D 2013 %R 10.1016/j.nephro.2012.09.006 %M 23332110 %K Angiotensine-2 %K AT1R %K Antagonistes des récepteurs à l'angiotensine-2 %K Inhibiteurs de l'enzyme de conversion %K Cancer %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Human health and pathology/Urology and NephrologyJournal articles %X Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to explore any pro- or antitumoral effect. We lack of prospective studies that could take off the doubt on these drugs. Nevertheless, all experimental researches pointed out potent antitumoral properties. Indeed, direct antiproliferative and neo-angiogenic inhibition have been described on tumor cell cultures as well as on animal models. Moreover, we are convinced that the use of antagonists of angiotensin-2 receptors and inhibitors of angiotensinogen converting enzyme may be then of clinical use in the near future in association with classical antitumor drugs. In this review, we proposed to explore these data by a thorough analysis of recent literature associating epidemiological and experimental studies. %G French %L inserm-00814037 %U https://inserm.hal.science/inserm-00814037 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ IFR140 %~ HL %~ IGDR %~ STATS-UR1 %~ IGDR-CR %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA