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["Table S3: Details of surface residues away from the interface undergoing PB change in proteins with substantial structural change in non-interacting regions and almost invariant / moderate change at interface."]
[null,"PDB code"]
["Protein","Bound","Unbound","Details of surface residues away from the interface undergoing PB change"]
["PIP3 kinase (O)","1HE8_r","1E8Z","E146(M^L@-1.083),N167(C^A@0.299),W201(C^F@-1.176),V202(D^B@-1.202),T203(F^L@-0.772),S204(B^C@-0.781),K214(M^P@-1.109),A216(N^M@-0.581),N217(O^L@-0.438),C219(A^C@0.299),D238(B^L@-0.087),A253(N^M@-0.581),K254(O^M@-1.307),D269(P^C@-0.004),F270(A^C@0.299),L281(F^E@0.703),V282(B^H@0.091),G283(P^I@0.706),E284(C^A@0.299),D316(P^C@-0.004),R319(D^E@-0.181),K320(D^H@-1.497),E321(E^J@-0.229),D356(H^L@-0.794),C357(I^K@-0.672),D358(A^B@-0.353),R359(D^C@-0.382),G367(J^N@-1.778),I368(A^O@-0.801),D369(C^P@-0.004),I370(F^A@-1.127),P371(B^K@-0.461),L373(C^N@-1.829),P374(D^M@-7.987),L379(F^L@-0.772),T380(B^A@-0.353),V381(A^C@0.299),F382(C^D@-0.382),H389(E^H@0.601),G390(H^J@1.101),Q391(I^A@-0.309),Q392(A^C@0.299),I469(F^G@-0.680),D470(K^F@-1.224),H471(L^K@-0.632),R472(O^L@-0.438),G478(I^J@1.010),Y480(D^C@-0.382),W485(F^D@-1.063),Q486(B^D@-1.202),I487(A^E@-1.736),S488(G^H@-1.029),N498(A^L@-1.411),A499(K^M@-1.647),L502(P^O@-0.010),N512(P^G@1.036),M514(C^D@-0.382),D521(E^D@-0.181),N522(H^D@-1.497),Y523(P^D@-2.890),C524(M^D@-7.987),H525(M^F@-2.621),P526(K^B@-0.461),I527(P^L@-2.065),S620(C^M@-2.777),A621(C^L@-3.830),L622(D^M@-7.987),D623(F^M@-2.621),V624(K^M@-1.647),G625(L^M@-1.083),F635(C^M@-2.777),S636(B^C@-0.781),D637(F^L@-0.772),Q705(M^C@-2.777),S706(M^F@-2.621),S751(N^M@-0.581),L752(O^G@0.486),S753(M^O@-1.307),S761(K^F@-1.224),Q762(L^K@-0.632),V763(M^L@-1.083),Q775(M^N@-0.581),N776(M^O@-1.307),S777(M^P@-1.109),Q778(M^B@-3.889),L779(G^C@0.504),P780(F^G@-0.680),E781(B^H@0.091),S782(D^I@-1.226),F783(C^A@0.299),V803(G^L@-0.948),A805(B^F@-2.260),S806(L^K@-0.632),K807(K^L@-0.632),K808(L^M@-1.083),D819(L^F@-0.772),T821(B^L@-0.087),A822(F^C@-1.176),L823(B^C@-0.781),S824(L^F@-0.772),N825(C^B@-0.781),D837(F^C@-1.176),Y867(D^C@-0.382),G873(N^B@-1.512),I876(A^H@-2.140),G877(I^J@1.010),I879(D^C@-0.382),T886(D^C@-0.382),S894(M^N@-0.581),T895(N^O@0.038),F902(A^P@-0.724),K903(C^A@0.299),T917(F^L@-0.772),E918(K^M@-1.647),N951(C^P@-0.004),H962(E^F@0.703),I963(H^K@0.714),D964(K^P@-2.033),F965(L^C@-3.830),G966(G^F@-0.680),H967(P^K@-2.033),E981(A^P@-0.724),R982(D^G@-1.880),V983(F^C@-1.176),P984(B^K@-0.461),F985(D^L@-3.295),V986(C^M@-2.777),L987(D^C@-0.382),T997(A^G@-0.093),S998(E^H@0.601),G999(H^J@1.101),K1001(B^N@-1.512),T1002(G^O@0.486),S1003(C^P@-0.004),P1004(K^M@-1.647),T1037(M^C@-2.777),D1047(M^C@-2.777),I1048(M^K@-1.647),E1049(M^L@-1.083),K1059(A^L@-1.411),N1060(F^K@-1.224),E1061(K^L@-0.632),E1062(L^M@-1.083)"]
["HISF protein  (O)","1GPW_r","1THF","V18(F^D@-1.063),K19(K^F@-1.224),G20(L^K@-0.632),N22(P^M@-1.109),F23(A^M@-3.273),E24(K^M@-1.647),N25(B^A@-0.353),L26(F^C@-1.176),R27(B^C@-0.781),D28(L^E@-2.899),S29(M^H@-3.671),G30(B^J@-0.763),D31(M^A@-3.273),P32(K^M@-1.647),I52(K^B@-0.461),T53(L^E@-2.899),A54(M^O@-1.307),S55(N^L@-0.336),V56(O^M@-1.307),K58(L^M@-1.083),Q72(P^C@-0.004),N148(G^E@0.818),R230(P^M@-1.109),E251(H^O@-0.133)"]
["UCH-L3 (O)","1XD3_r","1UCH","L7(C^D@-0.382),H26(C^F@-1.176),P27(F^K@-1.224),I91(F^G@-0.680),S92(K^H@0.714),N93(L^K@-0.632),A94(M^L@-1.083),S128(G^P@1.036),D142(M^K@-1.647),I144(C^M@-2.777),R145(F^M@-2.621),V166(K^F@-1.224),D167(P^B@-0.255),E219(M^C@-2.777)"]
["Son of Sevenless (O)","1BKD_r","2II0","P570(D^P@-2.890),S571(F^G@-0.680),A572(K^O@-3.006),V574(C^A@0.299),Y575(F^M@-2.621),R576(K^M@-1.647),F577(L^M@-1.083),A578(O^P@-0.010),D581(D^F@-1.063),S582(F^K@-1.224),E583(K^L@-0.632),E584(L^M@-1.083),F588(F^D@-1.063),E589(B^D@-1.202),E590(H^F@-0.492),I598(P^A@-0.724),P599(A^C@0.299),E652(D^E@-0.181),P653(D^H@-1.497),R676(M^J@-2.168),F677(M^A@-3.273),E680(M^L@-1.083),T720(O^P@-0.010),V721(G^M@-0.852),R722(H^B@0.091),G723(I^L@-0.010),K724(K^M@-1.647),K740(M^N@-0.581),K741(M^O@-1.307),T753(C^A@0.299),S756(D^A@-0.571),S766(G^C@0.504),V805(G^O@0.486),N976(B^P@-0.255),Q977(C^P@-0.004),N993(O^P@-0.010),Y1031(F^L@-0.772),S1032(B^C@-0.781),S1037(G^E@0.818),P1042(C^F@-1.176)"]
["TGF-beta (O)","1KTZ_r","1TGK","C15(C^L@-3.830),C16(D^C@-0.382),Q26(N^M@-0.581),D27(O^N@0.038),L28(P^O@-0.010),G29(A^P@-0.724),V33(N^M@-0.581),E35(I^D@-1.226),P36(A^F@-1.127),K37(B^K@-0.461),G38(D^B@-1.202),Y39(C^G@0.504),Y40(E^N@-2.239),P49(E^F@0.703),Y50(H^B@0.091),L51(I^A@-0.309),R52(A^G@-0.093),S53(P^H@-2.485),A54(O^H@-0.133),S73(M^I@-3.927),A74(O^A@-0.801),S75(P^C@-0.004),P76(C^D@-0.382),V98(D^F@-1.063),E99(D^B@-1.202),Q100(D^L@-3.295),L101(E^C@-1.642),K110(D^E@-0.181)"]
["HPr kinase C-ter domain (E)","1KKL_r","1JB1","R137(C^D@-0.382),S138(E^D@-0.181),G141(I^J@1.010),L143(D^C@-0.382),D156(A^E@-1.736),G160(P^M@-1.109),Q185(F^E@0.703),Q186(K^H@0.714),D187(L^J@0.019),E188(M^A@-3.273),D212(E^F@0.703),V213(H^K@0.714),A221(C^P@-0.004),E224(B^K@-0.461),D225(A^B@-0.353),T226(C^G@0.504),T227(D^C@-0.382),L234(F^D@-1.063),E235(K^D@-3.370),N236(L^D@-3.295),W237(M^D@-7.987),T238(G^F@-0.680),P239(H^B@0.091),D240(J^L@0.019),Q253(L^D@-3.295),L254(M^E@-5.828),I255(N^E@-2.239),F256(G^H@-1.029),D257(O^I@-1.549),V258(I^A@-0.309),P259(A^C@0.299),V260(A^D@-0.571),A280(N^M@-0.581),A281(O^M@-1.307),S288(M^N@-0.581),G290(C^P@-0.004),Y291(C^A@0.299) / R137(C^D@-0.382),S138(E^D@-0.181),G141(I^J@1.010),L143(D^C@-0.382),D156(A^E@-1.736),G158(K^J@0.398),G160(P^M@-1.109),H201(P^I@0.706),D212(E^F@0.703),V213(H^K@0.714),A221(C^P@-0.004),E224(E^K@-0.765),D225(H^B@0.091),T226(P^G@1.036),T227(A^C@0.299),L234(F^D@-1.063),E235(K^D@-3.370),N236(L^D@-3.295),W237(M^D@-7.987),T238(G^E@0.818),T252(J^D@-0.887),Q253(L^D@-3.295),L254(M^E@-5.828),I255(N^E@-2.239),F256(G^H@-1.029),D257(O^I@-1.549),V258(I^A@-0.309),P259(A^C@0.299),V260(A^D@-0.571),A280(N^M@-0.581),A281(O^M@-1.307),S288(M^N@-0.581),G290(C^P@-0.004),Y291(C^A@0.299) / G141(I^J@1.010),L143(D^C@-0.382),D156(A^E@-1.736),G158(K^J@0.398),G160(P^M@-1.109),H201(P^I@0.706),D212(E^F@0.703),V213(H^K@0.714),A221(C^P@-0.004),E224(B^K@-0.461),D225(A^B@-0.353),T226(C^G@0.504),T227(D^C@-0.382),L234(F^D@-1.063),E235(K^D@-3.370),N236(L^D@-3.295),W237(M^D@-7.987),T238(G^F@-0.680),P239(H^K@0.714),D240(J^A@-0.702),Q253(L^D@-3.295),L254(M^E@-5.828),I255(N^E@-2.239),F256(G^H@-1.029),D257(O^I@-1.549),V258(I^A@-0.309),P259(A^C@0.299),V260(A^D@-0.571),A280(N^M@-0.581),A281(O^M@-1.307),S288(M^N@-0.581),G290(C^P@-0.004),Y291(C^A@0.299)"]
["Cystatin (E)","1YVB_l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
["DH/PH domain of TRIO (O)","2NZ8_r","1NTY","G1266(C^F@-1.176),C1383(C^P@-0.004),K1388(A^H@-2.140),G1389(H^J@1.101),G1416(I^K@-0.672),F1417(A^L@-1.411),S1423(N^G@0.304),G1425(P^I@0.706),L1427(C^F@-1.176),K1464(F^D@-1.063),D1465(K^F@-1.224),S1466(L^K@-0.632),S1467(O^L@-0.438),F1479(F^D@-1.063),T1480(K^F@-1.224),S1481(L^B@-0.087),E1482(P^C@-0.004),G1484(C^D@-0.382),H1488(A^F@-1.127),V1489(G^N@0.304),E1490(H^L@-0.794),G1491(I^P@0.706),P1493(K^C@-3.195),C1494(B^D@-1.202),K1495(C^D@-0.382),F1496(C^F@-1.176),A1497(D^B@-1.202),T1505(F^D@-1.063),S1506(K^F@-1.224),D1507(L^K@-0.632),N1508(C^L@-3.830),K1509(C^P@-0.004),V1511(D^C@-0.382),S1516(F^L@-0.772)"]
["Actin (O)","2BTF_r","1IJJ","A6(C^I@-1.482),A7(D^A@-0.571),K18(E^D@-0.181),A19(H^F@-0.492),G20(J^B@-0.763),F21(A^G@-0.093),A26(D^A@-0.571),A29(A^D@-0.571),R37(D^F@-1.063),R39(H^O@-0.133),H40(K^P@-2.033),Q41(L^N@-0.336),G42(L^O@-0.438),V43(M^P@-1.109),M47(L^A@-1.411),G48(P^A@-0.724),Q49(A^D@-0.571),K50(C^F@-1.176),D51(D^B@-1.202),Y53(F^E@0.703),V54(K^H@0.714),G55(L^J@0.019),D56(M^L@-1.083),K61(L^M@-1.083),W79(M^K@-1.647),T148(G^E@0.818),D157(N^L@-0.336),G158(O^P@-0.010),V159(P^C@-0.004),T160(A^C@0.299),L178(F^D@-1.063),D179(B^D@-1.202),S199(C^F@-1.176),F200(D^F@-1.063),T202(F^O@-2.430),L216(O^P@-0.010),C217(M^C@-2.777),Y218(B^C@-0.781),V219(L^D@-3.295),A220(C^F@-1.176),F223(K^M@-1.647),S232(M^N@-0.581),S234(L^M@-1.083),S235(L^M@-1.083),E237(M^C@-2.777),K238(B^C@-0.781),S239(A^D@-0.571),Y240(C^D@-0.382),M305(B^P@-0.255),L320(G^P@1.036),P322(F^C@-1.176),S348(G^P@1.036),Q353(M^N@-0.581),Q354(M^O@-1.307),W356(C^A@0.299),S365(C^O@-0.645),G366(C^M@-2.777),P367(K^M@-1.647),S368(L^M@-1.083)"]
["Alpha-1-antitrypsin (E)","1OPH_r","1Q1P","K25(K^M@-1.647),I26(L^M@-1.083),S45(A^C@0.299),N46(C^K@-3.195),E86(M^B@-3.889),N104(C^M@-2.777),Q105(F^M@-2.621),P106(K^B@-0.461),D107(L^A@-1.411),Q109(G^K@-2.342),L110(H^L@-0.794),Q111(I^P@0.706),T113(C^D@-0.382),H139(M^P@-1.109),S140(B^A@-0.353),E141(A^C@0.299),A142(C^D@-0.382),G167(P^M@-1.109),V173(L^A@-1.411),V210(B^K@-0.461),D211(F^L@-0.772),Q212(K^M@-1.647),V213(B^P@-0.255),M226(L^G@-0.948),G246(J^I@1.010),A248(C^A@0.299),T249(C^D@-0.382),T309(K^M@-1.647),T322(M^C@-2.777),T345(F^G@-0.680),E346(B^O@-1.013),A347(D^I@-1.226),A348(C^H@-2.095),G349(D^J@-0.887),A350(D^L@-3.295),M351(D^M@-7.987),F352(D^P@-2.890),M385(F^C@-1.176),G386(B^D@-1.202),R387(L^D@-3.295),V388(C^F@-1.176),P391(K^M@-1.647),T392(L^B@-0.087)"]
["TGFbeta receptor (O)","1B6C_l","1IAS","T185(M^C@-2.777),T186(P^E@-3.587),S187(C^H@-2.095),G188(B^I@0.706),S189(F^L@-0.772),G190(C^K@-3.195),S191(F^L@-0.772),G192(B^M@-3.889),L193(L^G@-0.948),T204(C^P@-0.004),S210(G^F@-0.680),I211(H^B@0.091),G212(N^D@-5.175),K213(O^F@-2.430),G214(J^K@0.398),V219(C^D@-0.382),V252(O^C@-0.645),M253(P^C@-0.004),L254(A^D@-0.571),R255(C^D@-0.382),N258(L^B@-0.087),N267(F^D@-1.063),K268(K^D@-3.370),D269(B^D@-1.202),N270(O^F@-2.430),G271(M^K@-1.647),T272(L^B@-0.087),W273(O^C@-0.645),Q275(C^D@-0.382),V279(F^D@-1.063),S280(B^D@-1.202),D281(L^D@-3.295),Y282(C^D@-0.382),R294(M^P@-1.109),Y295(B^C@-0.781),T296(G^C@0.504),V297(C^D@-0.382),G322(J^F@0.001),T323(L^K@-0.632),Q324(P^N@0.529),G325(C^O@-0.645),K326(C^P@-0.004),P327(D^A@-0.571),A330(F^E@0.703),D333(G^A@-0.093),L334(H^C@-2.095),K335(I^F@-2.887),I349(E^F@0.703),A350(H^K@0.714),D351(I^L@-0.010),L352(L^M@-1.083),L354(P^B@-0.255),A361(L^N@-0.336),I367(F^D@-1.063),A368(B^D@-1.202),P369(L^D@-3.295),N370(P^F@-2.417),H371(A^B@-0.353),R372(E^D@-0.181),V373(H^C@-2.095),G374(I^D@-1.226),Y378(O^P@-0.010),D386(P^M@-1.109),N389(C^F@-1.176),R414(M^P@-1.109),I417(H^E@0.601),I420(A^M@-3.273),H421(C^B@-0.781),E422(D^G@-1.880),D423(D^C@-0.382),L431(C^P@-0.004),S460(P^M@-1.109),E462(K^M@-1.647),Y476(M^F@-2.621),G479(K^M@-1.647),Q498(G^N@0.304)"]
["Vitamin D binding protein (O)","1KXP_l","1KW2","C75(M^P@-1.109),A76(N^G@0.304),E77(O^H@-0.133),G78(C^I@-1.482),C96(G^P@1.036),E97(F^G@-0.680),S98(K^H@0.714),N99(L^I@-0.010),S100(C^A@0.299),L126(C^I@-1.482),K127(C^A@0.299),H128(D^C@-0.382),Q169(B^P@-0.255),T191(G^P@1.036),S192(F^C@-1.176),C266(P^M@-1.109),E267(C^P@-0.004),S268(F^C@-1.176),A269(K^B@-0.461),S270(L^F@-0.772),E271(C^K@-3.195),D272(C^L@-3.830),C273(K^M@-1.647),M274(L^M@-1.083),Q301(C^P@-0.004),T330(B^F@-2.260),N331(F^K@-1.224),K332(K^L@-0.632),D333(L^M@-1.083),D336(M^G@-0.852),P337(K^H@0.714),G338(B^I@0.706),N339(C^L@-3.830),T340(K^L@-0.632),K341(L^M@-1.083),R353(M^C@-2.777),D377(G^P@1.036),K471(P^M@-1.109)"]
["TolB (O)","2HQS_r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
["RCC1 (O)","1I2M_l","1A12","S26(B^C@-0.781),H27(L^F@-0.772),R28(M^K@-1.647),V54(M^C@-2.777),K120(C^D@-0.382),L156(P^M@-1.109),Q169(F^D@-1.063),L170(K^F@-1.224),D171(L^B@-0.087),V172(C^D@-0.382),V207(M^C@-2.777),P208(M^F@-2.621),E209(L^K@-0.632),L210(M^L@-1.083),F211(G^M@-0.852),A212(O^N@0.038),N213(P^G@1.036),R214(A^O@-0.801),G215(C^L@-3.830),G216(K^M@-1.647),R217(L^N@-0.336),Q218(M^O@-1.307),G219(M^P@-1.109),L220(M^K@-1.647),E221(M^L@-1.083),K232(E^D@-0.181),H239(C^D@-0.382),V240(C^D@-0.382),T274(A^N@-2.223),P275(B^O@-1.013),G276(F^P@-2.417),T277(C^A@0.299),S279(C^D@-0.382),I282(D^A@-0.571),F289(P^C@-0.004),K290(C^N@-1.829),N291(F^O@-2.430),S292(K^L@-0.632),T293(B^A@-0.353),L344(C^F@-1.176),P345(C^B@-0.781),A346(D^A@-0.571),V347(F^C@-1.176),M391(F^E@0.703),M392(B^H@0.091),G393(L^F@-0.772),K394(M^K@-1.647)"]
["Sporulation response factor B (O)","1F51_r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
["Ran GTPase (O)","1A2K_l","1QG4","T21(L^O@-0.438),G22(M^P@-1.109),R29(M^P@-1.109),R56(L^H@-0.794),I59(C^D@-0.382),Y80(G^N@0.304),T93(B^L@-0.087),V111(N^M@-0.581),C112(O^M@-1.307),E113(P^M@-1.109),N114(A^L@-1.411),P116(D^C@-0.382),R129(F^C@-1.176),F138(M^B@-3.889),H139(M^C@-2.777),R140(M^F@-2.621),K141(N^K@-1.631),K142(O^L@-0.438),N143(P^C@-0.004),L144(A^C@0.299)"]
["HEW lysozyme (A)","1BVK_l","3LZT","G16(P^M@-1.109),S50(A^C@0.299),W63(P^M@-1.109),C64(C^M@-2.777),N65(E^N@-2.239),D66(H^O@-0.133),R73(K^O@-3.006),L84(P^C@-0.004),S100(N^M@-0.581),D101(O^L@-0.438),G102(P^M@-1.109),G104(K^M@-1.647),M105(L^M@-1.083),V109(K^M@-1.647),G126(I^P@0.706)"]
["Transferrin receptor ectodomain (O)","1DE4_l","1CX8","S137(C^P@-0.004),N148(C^G@0.504),V153(M^P@-1.109),P154(L^A@-1.411),E156(G^E@0.818),G158(K^I@-0.672),S159(L^A@-1.411),Q160(M^K@-1.647),K161(M^L@-1.083),L178(F^A@-1.127),V181(M^C@-2.777),W182(B^D@-1.202),R183(L^D@-3.295),D184(C^D@-0.382),K189(D^F@-1.063),I190(D^B@-1.202),Q191(D^A@-0.571),V192(D^C@-0.382),A196(A^D@-0.571),V203(F^D@-1.063),D204(K^F@-1.224),K205(L^E@-2.899),N206(P^O@-0.010),G207(A^P@-0.724),R208(N^A@-2.223),L209(B^A@-0.353),V210(P^F@-2.417),Y211(C^K@-3.195),L212(F^L@-0.772),V213(B^A@-0.353),V220(C^G@0.504),A225(F^D@-1.063),A226(B^D@-1.202),T227(C^D@-0.382),V228(G^E@0.818),H234(D^F@-1.063),A235(E^B@-0.813),N236(H^L@-0.794),F237(H^O@-0.133),G238(H^I@-0.471),T239(N^A@-2.223),K240(O^K@-3.006),K241(M^L@-1.083),D245(C^P@-0.004),L246(F^M@-2.621),T248(A^D@-0.571),P249(C^F@-1.176),I254(D^C@-0.382),R258(D^E@-0.181),A259(F^E@0.703),G260(K^H@0.714),K261(L^I@-0.010),I262(M^A@-3.273),T263(M^F@-2.621),F264(M^K@-1.647),N275(M^P@-1.109),A276(N^A@-2.223),I277(O^C@-0.645),G278(P^I@0.706),F288(M^O@-1.307),A293(K^M@-1.647),G299(F^D@-1.063),H300(K^F@-1.224),A301(I^B@0.706),H302(A^E@-1.736),L303(F^H@-0.492),G304(B^J@-0.763),T305(O^A@-0.801),G306(P^C@-0.004),D307(A^F@-1.127),P308(M^K@-1.647),S315(F^D@-1.063),F316(K^F@-1.224),N317(L^K@-0.632),H318(M^L@-1.083),T319(N^O@0.038),Q320(O^P@-0.010),F321(P^A@-0.724),P323(F^D@-1.063),S324(K^D@-3.370),R325(L^D@-3.295),S326(N^F@-3.415),S327(O^K@-3.006),G328(P^B@-0.255),L329(A^C@0.299),P330(K^C@-3.195),N331(P^B@-0.255),I332(A^D@-0.571),M349(F^G@-0.680),E350(B^H@0.091),G351(D^I@-1.226),D352(C^A@0.299),W357(A^O@-0.801),K358(M^P@-1.109),T359(B^A@-0.353),D360(G^F@-0.680),S361(H^K@0.714),T362(I^B@0.706),C363(L^C@-3.830),R364(K^G@-2.342),M365(L^H@-0.794),V366(C^I@-1.482),T367(C^A@0.299),K371(M^C@-2.777),N372(B^C@-0.781),V373(L^D@-3.295),K374(C^D@-0.382),V377(D^F@-1.063),S378(D^B@-1.202),V380(D^C@-0.382),I389(F^D@-1.063),F390(K^D@-3.370),G391(P^D@-2.890),V392(A^D@-0.571),K394(F^D@-1.063),G395(K^F@-1.224),F396(L^K@-0.632),V397(M^L@-1.083),A417(L^M@-1.083),V461(M^L@-1.083),S472(L^M@-1.083),L474(M^G@-0.852),H475(M^O@-1.307),L476(M^K@-1.647),K477(M^B@-3.889),S492(M^P@-1.109),N493(M^A@-3.273),F494(O^C@-0.645),K495(C^D@-0.382),N512(B^C@-0.781),T518(M^O@-1.307),G519(C^P@-0.004),Q520(D^A@-0.571),Q524(F^B@-2.260),D525(K^F@-1.224),S526(B^K@-0.461),N527(C^L@-3.830),W528(B^M@-3.889),A529(D^M@-7.987),S530(C^M@-2.777),K531(D^C@-0.382),V532(D^C@-0.382),E533(D^C@-0.382),N539(F^M@-2.621),C556(F^D@-1.063),F557(D^F@-1.063),C558(D^B@-1.202),E559(F^L@-0.772),D560(B^C@-0.781),Y565(L^G@-0.948),L566(M^O@-1.307),G567(P^K@-2.033),T568(C^L@-3.830),T569(K^M@-1.647),M570(L^M@-1.083),D571(P^C@-0.004),R579(N^M@-0.581),D604(M^O@-1.307),E606(D^A@-0.571),N608(D^B@-1.202),E634(P^N@0.529),M635(M^O@-1.307),G636(C^P@-0.004),L637(L^A@-1.411),S638(O^F@-2.430),L639(L^K@-0.632),E664(C^F@-1.176),F685(G^P@1.036),P696(P^M@-1.109),H699(L^F@-0.772),H707(L^B@-0.087),K720(N^M@-0.581),N722(M^G@-0.852),N723(M^H@-3.671),G724(M^K@-1.647),A725(P^L@-2.065),A748(N^M@-0.581),L749(O^N@0.038),S750(N^O@0.038),G751(N^P@0.529),D752(P^F@-2.417),V753(A^K@-3.181),W754(I^L@-0.010) / S137(C^P@-0.004),N148(C^G@0.504),V153(M^P@-1.109),P154(L^A@-1.411),E156(G^E@0.818),G158(K^I@-0.672),S159(L^A@-1.411),Q160(M^K@-1.647),K161(M^L@-1.083),L178(M^A@-3.273),V181(M^C@-2.777),W182(B^D@-1.202),R183(L^D@-3.295),D184(C^D@-0.382),K189(D^F@-1.063),I190(D^B@-1.202),Q191(D^A@-0.571),V192(D^C@-0.382),A196(A^D@-0.571),V203(F^D@-1.063),D204(K^F@-1.224),K205(O^K@-3.006),N206(P^L@-2.065),G207(A^P@-0.724),R208(F^A@-1.127),L209(K^F@-1.224),V210(B^K@-0.461),Y211(G^L@-0.948),L212(F^P@-2.417),V213(B^A@-0.353),V220(C^G@0.504),A225(F^D@-1.063),A226(B^D@-1.202),T227(C^D@-0.382),V228(G^E@0.818),H234(D^F@-1.063),A235(E^B@-0.813),N236(H^G@-1.029),F237(H^O@-0.133),G238(H^I@-0.471),T239(N^A@-2.223),K240(O^K@-3.006),K241(M^L@-1.083),D245(C^P@-0.004),L246(F^M@-2.621),T248(A^D@-0.571),P249(C^F@-1.176),I254(D^C@-0.382),R258(D^E@-0.181),A259(F^E@0.703),G260(K^H@0.714),K261(L^I@-0.010),I262(M^A@-3.273),T263(M^F@-2.621),F264(M^K@-1.647),N275(M^P@-1.109),A276(N^A@-2.223),I277(O^C@-0.645),G278(P^I@0.706),F288(M^O@-1.307),A293(K^M@-1.647),G299(F^D@-1.063),H300(K^F@-1.224),A301(I^B@0.706),H302(A^E@-1.736),L303(F^H@-0.492),G304(B^J@-0.763),T305(O^A@-0.801),G306(P^C@-0.004),D307(A^F@-1.127),P308(M^K@-1.647),S315(F^D@-1.063),F316(K^F@-1.224),N317(L^K@-0.632),H318(M^L@-1.083),T319(N^O@0.038),Q320(O^P@-0.010),F321(P^A@-0.724),P323(F^D@-1.063),S324(K^D@-3.370),R325(L^D@-3.295),S326(N^F@-3.415),S327(O^K@-3.006),G328(P^B@-0.255),L329(A^C@0.299),P330(K^C@-3.195),N331(I^B@0.706),I332(A^D@-0.571),M349(F^G@-0.680),E350(B^H@0.091),G351(D^I@-1.226),D352(C^A@0.299),W357(A^O@-0.801),K358(M^P@-1.109),T359(B^A@-0.353),D360(G^F@-0.680),S361(H^K@0.714),T362(I^B@0.706),C363(L^C@-3.830),R364(K^G@-2.342),M365(L^H@-0.794),V366(C^I@-1.482),T367(C^A@0.299),K371(M^C@-2.777),N372(B^C@-0.781),V373(L^D@-3.295),K374(C^D@-0.382),V377(D^F@-1.063),S378(D^B@-1.202),V380(D^C@-0.382),I389(F^D@-1.063),F390(K^D@-3.370),G391(P^D@-2.890),V392(A^D@-0.571),K394(F^D@-1.063),G395(K^F@-1.224),F396(L^K@-0.632),V397(M^L@-1.083),A417(L^M@-1.083),V461(M^L@-1.083),S472(L^M@-1.083),L474(M^G@-0.852),H475(M^O@-1.307),L476(M^K@-1.647),K477(M^A@-3.273),V488(L^F@-0.772),S492(M^P@-1.109),N493(M^A@-3.273),F494(O^C@-0.645),K495(C^D@-0.382),N512(B^C@-0.781),T518(M^O@-1.307),G519(C^P@-0.004),Q520(D^A@-0.571),Q524(F^B@-2.260),D525(K^F@-1.224),S526(B^K@-0.461),N527(C^L@-3.830),W528(B^M@-3.889),A529(D^M@-7.987),S530(C^M@-2.777),K531(D^C@-0.382),V532(D^C@-0.382),E533(D^C@-0.382),N539(F^M@-2.621),C556(F^D@-1.063),F557(D^F@-1.063),C558(D^B@-1.202),E559(F^L@-0.772),D560(B^C@-0.781),Y565(L^G@-0.948),L566(M^O@-1.307),G567(P^K@-2.033),T568(C^L@-3.830),T569(K^M@-1.647),M570(L^M@-1.083),D571(P^C@-0.004),R579(N^M@-0.581),H603(P^M@-1.109),V605(B^P@-0.255),E606(D^C@-0.382),N608(D^B@-1.202),E634(P^N@0.529),M635(M^O@-1.307),G636(C^P@-0.004),L637(L^A@-1.411),S638(O^F@-2.430),L639(L^K@-0.632),Q640(M^L@-1.083),E664(C^F@-1.176),F685(G^P@1.036),H699(L^F@-0.772),G705(J^P@-0.377),S706(L^K@-0.632),H707(P^B@-0.255),K720(N^M@-0.581),N722(M^G@-0.852),N723(M^H@-3.671),G724(M^K@-1.647),A725(P^L@-2.065),A748(N^M@-0.581),S750(N^O@0.038),G751(N^P@0.529),D752(P^F@-2.417),V753(A^K@-3.181),W754(I^L@-0.010)"]
["Anthrax toxin receptor (O)","1T6B_l","1SHU","F43(C^D@-0.382),E77(L^B@-0.087),R111(P^O@-0.010),D191(B^K@-0.461),S192(F^L@-0.772),K193(K^M@-1.647),E194(L^M@-1.083),Q195(C^P@-0.004),K200(G^H@-1.029),G201(H^P@-2.485),G202(I^L@-0.010),F203(L^M@-1.083)"]
["Xylanase inhibitor (E)","2B42_r","1T6E","K40(E^F@0.703),G41(H^B@0.091),E47(D^B@-1.202),I48(D^C@-0.382),S52(M^F@-2.621),A60(M^P@-1.109),A63(E^F@0.703),P64(H^K@0.714),G65(I^B@0.706),C66(A^N@-2.223),P67(K^O@-3.006),A68(L^P@-2.065),K78(I^A@-0.309),V88(N^L@-0.336),K159(M^P@-1.109),V160(B^A@-0.353),A161(P^D@-2.890),N162(C^D@-0.382),G180(I^L@-0.010),G181(A^P@-0.724),V183(E^G@0.818),S191(O^P@-0.010),D217(A^L@-1.411),G225(K^I@-0.672),L227(C^M@-2.777),A228(G^N@0.304),T229(H^O@-0.133),G230(I^P@0.706),A261(N^M@-0.581),Q262(O^M@-1.307),A270(P^D@-2.890),R271(A^D@-0.571),A272(D^F@-1.063),V273(D^B@-1.202),V274(D^L@-3.295),A275(D^C@-0.382),G335(J^I@1.010),V336(O^A@-0.801),A337(P^E@-3.587),A338(A^H@-2.140),L367(C^D@-0.382),G377(P^F@-2.417),C378(N^E@-2.239)"]
["Fab (A)","1E6J_r","1E6O","Q3(C^D@-0.382),S7(F^D@-1.063),G8(B^D@-1.202),A9(A^D@-0.571),E10(C^D@-0.382),G42(K^I@-0.672),Q43(B^A@-0.353),G44(C^O@-0.645),L45(C^I@-1.482),E46(D^A@-0.571),D90(G^P@1.036),S91(O^M@-1.307),A92(J^B@-0.763),V93(A^L@-1.411),P133(E^D@-0.181),G134(H^E@0.601),S135(F^H@-0.492),A136(K^J@0.398),A137(L^O@-0.438),Q138(M^P@-1.109),T139(P^F@-2.417),N140(M^K@-1.647),S141(B^L@-0.087),M142(A^C@0.299),L145(D^F@-1.063),G146(D^B@-1.202),C147(D^L@-3.295),L148(D^C@-0.382),W161(E^H@0.601),G164(P^L@-2.065),G169(P^A@-0.724),L177(E^F@0.703),Q178(E^K@-0.765),S179(H^L@-0.794),D180(I^C@-1.482),L181(A^C@0.299),E198(A^C@0.299) / V3(D^C@-0.382),S27(A^D@-0.571),L53(C^F@-1.176),A54(E^B@-0.813),S55(H^L@-0.794),G56(I^P@0.706),D81(G^P@1.036),A82(O^M@-1.307),A83(J^B@-0.763),I84(A^L@-1.411),Y138(F^D@-1.063),P139(K^F@-1.224),K140(L^B@-0.087),D141(C^D@-0.382),S169(M^P@-1.109),T170(B^A@-0.353),Y171(A^C@0.299),S172(C^D@-0.382),R186(P^M@-1.109),H187(C^M@-2.777),N188(B^M@-3.889),S189(D^C@-0.382),S199(C^F@-1.176)"]
["Complement C3 (O)","1GHQ_r","1C3D","L10(M^P@-1.109),F66(P^C@-0.004),F76(F^L@-0.772),K118(P^C@-0.004),I132(K^B@-0.461),G138(M^J@-2.168),K222(G^H@-1.029),D229(D^E@-0.181),P230(F^E@0.703),G231(B^H@0.091),K232(L^I@-0.010),Q233(M^A@-3.273),E265(N^P@0.529),Q266(O^C@-0.645),R267(P^F@-2.417),Y268(G^K@-2.342),Y269(G^N@0.304),G270(G^N@0.304),G271(I^O@-1.549),G272(I^G@-0.421),Y273(H^O@-0.133),G274(K^I@-0.672)"]
[]
["*The abbreviations used are: l – ligand (smaller of the two proteins in the complex), r – receptor (bigger of the two proteins in the complex), E – enzyme-inhibitor complex, A – Antigen-antibody complex, O – Other complexes. "]
["For every non-interacting surface residue undergoing PB change, details are presented in the following format: Single-letter code of aminoacid followed by residue number as given in bound form PDB file (PB in unbound form ^ PB in bound form @ PB substitution score for the PB change). The residues are delimited by commas."]
["In a few of the PDBs, the entry under consideration consists of multiple chains taken as a single entity. Therefore, the residue numbering can be repeated in case a PB change is observed in both cases. The residue details between two chains are demarcated using ‘/’ . The PDB entries belonging to this category are listed, along with the order of the chains used for concatenation: 1KKL – CBA, 1F51 – BA, 1DE4 – CF, 1E6J – HL. "]

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