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{"sheet":"Add. file 3 - Fu. Annot. Clust.","index":0,"n_rows":482,"n_cols":13,"rows_kept":482,"cut":false,"hidden":false,"merged":[[0,0,0,6],[1,0,1,1],[1,2,1,3],[1,8,1,9],[0,7,0,12]]}
["DE group",{"$nulls":6},"IDD group"]
["Experiment (e)",null,"Overlap (et)",null,"Time(t): The length of the list is >3000 genes, clustering impossible","Unique Experiment (e-t)","Unique Time (t-e)","Experiment (e)","Overlap (et)",null,"Time (t)","Unique Experiment (e-t)","Unique Time (t-e)"]
["Annotation Cluster 1","Enrichment Score: 10.088152901386438","Annotation Cluster 1","Enrichment Score: 10.459869819552052"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0031974~membrane-enclosed lumen","GOTERM_CC_FAT","GO:0031974~membrane-enclosed lumen"]
["GOTERM_CC_FAT","GO:0043233~organelle lumen","GOTERM_CC_FAT","GO:0043233~organelle lumen"]
["GOTERM_CC_FAT","GO:0070013~intracellular organelle lumen","GOTERM_CC_FAT","GO:0070013~intracellular organelle lumen"]
["GOTERM_CC_FAT","GO:0031981~nuclear lumen","GOTERM_CC_FAT","GO:0031981~nuclear lumen"]
["GOTERM_CC_FAT","GO:0005654~nucleoplasm","GOTERM_CC_FAT","GO:0005654~nucleoplasm"]
["GOTERM_CC_FAT","GO:0044451~nucleoplasm part","GOTERM_CC_FAT","GO:0044451~nucleoplasm part"]
["GOTERM_CC_FAT","GO:0005730~nucleolus","GOTERM_CC_FAT","GO:0005730~nucleolus"]
[]
["Annotation Cluster 2","Enrichment Score: 8.654054235079041","Annotation Cluster 3","Enrichment Score: 8.060372612222274"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","atp-binding","SP_PIR_KEYWORDS","atp-binding"]
["SP_PIR_KEYWORDS","nucleotide-binding","SP_PIR_KEYWORDS","nucleotide-binding"]
["GOTERM_MF_FAT","GO:0000166~nucleotide binding","GOTERM_MF_FAT","GO:0000166~nucleotide binding"]
["GOTERM_MF_FAT","GO:0005524~ATP binding","GOTERM_MF_FAT","GO:0005524~ATP binding"]
["GOTERM_MF_FAT","GO:0032559~adenyl ribonucleotide binding","GOTERM_MF_FAT","GO:0032559~adenyl ribonucleotide binding"]
["UP_SEQ_FEATURE","nucleotide phosphate-binding region:ATP","SP_PIR_KEYWORDS","transferase"]
["GOTERM_MF_FAT","GO:0030554~adenyl nucleotide binding","UP_SEQ_FEATURE","nucleotide phosphate-binding region:ATP"]
["GOTERM_MF_FAT","GO:0001883~purine nucleoside binding","GOTERM_MF_FAT","GO:0030554~adenyl nucleotide binding"]
["GOTERM_MF_FAT","GO:0001882~nucleoside binding","GOTERM_MF_FAT","GO:0001883~purine nucleoside binding"]
["SP_PIR_KEYWORDS","kinase","GOTERM_MF_FAT","GO:0001882~nucleoside binding"]
["SP_PIR_KEYWORDS","transferase","SP_PIR_KEYWORDS","kinase"]
["GOTERM_MF_FAT","GO:0032553~ribonucleotide binding","GOTERM_MF_FAT","GO:0032553~ribonucleotide binding"]
["GOTERM_MF_FAT","GO:0032555~purine ribonucleotide binding","GOTERM_MF_FAT","GO:0032555~purine ribonucleotide binding"]
["GOTERM_MF_FAT","GO:0017076~purine nucleotide binding","GOTERM_MF_FAT","GO:0017076~purine nucleotide binding"]
["GOTERM_BP_FAT","GO:0006796~phosphate metabolic process","GOTERM_BP_FAT","GO:0006796~phosphate metabolic process"]
["GOTERM_BP_FAT","GO:0006793~phosphorus metabolic process","GOTERM_BP_FAT","GO:0006793~phosphorus metabolic process"]
["GOTERM_BP_FAT","GO:0016310~phosphorylation","UP_SEQ_FEATURE","binding site:ATP"]
["UP_SEQ_FEATURE","binding site:ATP","GOTERM_BP_FAT","GO:0016310~phosphorylation"]
["SP_PIR_KEYWORDS","serine/threonine-protein kinase","SP_PIR_KEYWORDS","serine/threonine-protein kinase"]
["UP_SEQ_FEATURE","domain:Protein kinase","UP_SEQ_FEATURE","domain:Protein kinase"]
["GOTERM_BP_FAT","GO:0006468~protein amino acid phosphorylation","UP_SEQ_FEATURE","active site:Proton acceptor"]
["UP_SEQ_FEATURE","active site:Proton acceptor","GOTERM_MF_FAT","GO:0004674~protein serine/threonine kinase activity"]
["INTERPRO","IPR000719:Protein kinase, core","GOTERM_BP_FAT","GO:0006468~protein amino acid phosphorylation"]
["GOTERM_MF_FAT","GO:0004672~protein kinase activity","INTERPRO","IPR000719:Protein kinase, core"]
["GOTERM_MF_FAT","GO:0004674~protein serine/threonine kinase activity","GOTERM_MF_FAT","GO:0004672~protein kinase activity"]
["INTERPRO","IPR017441:Protein kinase, ATP binding site","INTERPRO","IPR017441:Protein kinase, ATP binding site"]
["INTERPRO","IPR008271:Serine/threonine protein kinase, active site","INTERPRO","IPR008271:Serine/threonine protein kinase, active site"]
["INTERPRO","IPR017442:Serine/threonine protein kinase-related","INTERPRO","IPR017442:Serine/threonine protein kinase-related"]
["INTERPRO","IPR002290:Serine/threonine protein kinase","INTERPRO","IPR002290:Serine/threonine protein kinase"]
["SMART","SM00220:S_TKc","SMART","SM00220:S_TKc"]
[]
["Annotation Cluster 3","Enrichment Score: 8.146703057565384","Annotation Cluster 2","Enrichment Score: 8.144998448663276"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0031975~envelope","GOTERM_CC_FAT","GO:0031090~organelle membrane"]
["GOTERM_CC_FAT","GO:0031967~organelle envelope","GOTERM_CC_FAT","GO:0031975~envelope"]
["GOTERM_CC_FAT","GO:0031090~organelle membrane","GOTERM_CC_FAT","GO:0005739~mitochondrion"]
["GOTERM_CC_FAT","GO:0005739~mitochondrion","GOTERM_CC_FAT","GO:0031967~organelle envelope"]
["SP_PIR_KEYWORDS","mitochondrion","SP_PIR_KEYWORDS","mitochondrion"]
["GOTERM_CC_FAT","GO:0005740~mitochondrial envelope","GOTERM_CC_FAT","GO:0005740~mitochondrial envelope"]
["GOTERM_CC_FAT","GO:0044429~mitochondrial part","GOTERM_CC_FAT","GO:0044429~mitochondrial part"]
["GOTERM_CC_FAT","GO:0031966~mitochondrial membrane","GOTERM_CC_FAT","GO:0031966~mitochondrial membrane"]
["GOTERM_CC_FAT","GO:0019866~organelle inner membrane","GOTERM_CC_FAT","GO:0019866~organelle inner membrane"]
["GOTERM_CC_FAT","GO:0005743~mitochondrial inner membrane","GOTERM_CC_FAT","GO:0005743~mitochondrial inner membrane"]
["SP_PIR_KEYWORDS","mitochondrion inner membrane","SP_PIR_KEYWORDS","mitochondrion inner membrane"]
[]
["Annotation Cluster 4","Enrichment Score: 6.113163099485044","Annotation Cluster 7","Enrichment Score: 5.4741432723680745"]
["Category","Term","Category","Term"]
["UP_SEQ_FEATURE","domain:SH3","SP_PIR_KEYWORDS","sh3 domain"]
["SP_PIR_KEYWORDS","sh3 domain","UP_SEQ_FEATURE","domain:SH3"]
["INTERPRO","IPR001452:Src homology-3 domain","INTERPRO","IPR001452:Src homology-3 domain"]
["SMART","SM00326:SH3","SMART","SM00326:SH3"]
[]
["Annotation Cluster 5","Enrichment Score: 5.942415997377194","Annotation Cluster 5","Enrichment Score: 6.295754097164832"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0005739~mitochondrion","GOTERM_CC_FAT","GO:0005739~mitochondrion"]
["SP_PIR_KEYWORDS","mitochondrion","SP_PIR_KEYWORDS","mitochondrion"]
["GOTERM_CC_FAT","GO:0044429~mitochondrial part","GOTERM_CC_FAT","GO:0044429~mitochondrial part"]
["SP_PIR_KEYWORDS","transit peptide","SP_PIR_KEYWORDS","transit peptide"]
["UP_SEQ_FEATURE","transit peptide:Mitochondrion","UP_SEQ_FEATURE","transit peptide:Mitochondrion"]
["GOTERM_CC_FAT","GO:0031980~mitochondrial lumen","GOTERM_CC_FAT","GO:0031980~mitochondrial lumen"]
["GOTERM_CC_FAT","GO:0005759~mitochondrial matrix","GOTERM_CC_FAT","GO:0005759~mitochondrial matrix"]
[]
["Annotation Cluster 6","Enrichment Score: 5.313393692024493","Annotation Cluster 6","Enrichment Score: 5.931213693740323"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0044265~cellular macromolecule catabolic process","GOTERM_BP_FAT","GO:0009057~macromolecule catabolic process"]
["GOTERM_BP_FAT","GO:0009057~macromolecule catabolic process","GOTERM_BP_FAT","GO:0044265~cellular macromolecule catabolic process"]
["GOTERM_BP_FAT","GO:0030163~protein catabolic process","GOTERM_BP_FAT","GO:0030163~protein catabolic process"]
["GOTERM_BP_FAT","GO:0051603~proteolysis involved in cellular protein catabolic process","GOTERM_BP_FAT","GO:0051603~proteolysis involved in cellular protein catabolic process"]
["GOTERM_BP_FAT","GO:0044257~cellular protein catabolic process","GOTERM_BP_FAT","GO:0044257~cellular protein catabolic process"]
["GOTERM_BP_FAT","GO:0019941~modification-dependent protein catabolic process","GOTERM_BP_FAT","GO:0019941~modification-dependent protein catabolic process"]
["GOTERM_BP_FAT","GO:0043632~modification-dependent macromolecule catabolic process","GOTERM_BP_FAT","GO:0043632~modification-dependent macromolecule catabolic process"]
["GOTERM_BP_FAT","GO:0006511~ubiquitin-dependent protein catabolic process","SP_PIR_KEYWORDS","ubl conjugation pathway"]
["SP_PIR_KEYWORDS","ubl conjugation pathway","GOTERM_BP_FAT","GO:0006511~ubiquitin-dependent protein catabolic process"]
["GOTERM_BP_FAT","GO:0006508~proteolysis","GOTERM_BP_FAT","GO:0006508~proteolysis"]
[]
["Annotation Cluster 7","Enrichment Score: 4.999810260843096","Annotation Cluster 4","Enrichment Score: 6.418422966376932"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","protein transport","SP_PIR_KEYWORDS","protein transport"]
["GOTERM_BP_FAT","GO:0015031~protein transport","GOTERM_BP_FAT","GO:0046907~intracellular transport"]
["GOTERM_BP_FAT","GO:0045184~establishment of protein localization","GOTERM_BP_FAT","GO:0015031~protein transport"]
["GOTERM_BP_FAT","GO:0046907~intracellular transport","GOTERM_BP_FAT","GO:0045184~establishment of protein localization"]
["GOTERM_BP_FAT","GO:0008104~protein localization","GOTERM_BP_FAT","GO:0008104~protein localization"]
["GOTERM_BP_FAT","GO:0006886~intracellular protein transport","GOTERM_BP_FAT","GO:0006886~intracellular protein transport"]
["GOTERM_BP_FAT","GO:0070727~cellular macromolecule localization","GOTERM_BP_FAT","GO:0070727~cellular macromolecule localization"]
["GOTERM_BP_FAT","GO:0034613~cellular protein localization","GOTERM_BP_FAT","GO:0034613~cellular protein localization"]
["GOTERM_BP_FAT","GO:0006605~protein targeting","GOTERM_BP_FAT","GO:0006605~protein targeting"]
["GOTERM_BP_FAT","GO:0033365~protein localization in organelle","GOTERM_BP_FAT","GO:0033365~protein localization in organelle"]
["GOTERM_BP_FAT","GO:0006913~nucleocytoplasmic transport","Annotation Cluster 24","Enrichment Score: 2.6352835284712723"]
["GOTERM_BP_FAT","GO:0051169~nuclear transport","Category","Term"]
["GOTERM_BP_FAT","GO:0017038~protein import","GOTERM_BP_FAT","GO:0006886~intracellular protein transport"]
["GOTERM_BP_FAT","GO:0006606~protein import into nucleus","GOTERM_BP_FAT","GO:0006605~protein targeting"]
["GOTERM_BP_FAT","GO:0051170~nuclear import","GOTERM_BP_FAT","GO:0033365~protein localization in organelle"]
["GOTERM_BP_FAT","GO:0034504~protein localization in nucleus","GOTERM_BP_FAT","GO:0006913~nucleocytoplasmic transport"]
["GOTERM_BP_FAT","GO:0000060~protein import into nucleus, translocation","GOTERM_BP_FAT","GO:0051169~nuclear transport"]
[null,null,"GOTERM_BP_FAT","GO:0017038~protein import"]
[null,null,"GOTERM_BP_FAT","GO:0006606~protein import into nucleus"]
[null,null,"GOTERM_BP_FAT","GO:0051170~nuclear import"]
[null,null,"GOTERM_BP_FAT","GO:0034504~protein localization in nucleus"]
[null,null,"GOTERM_BP_FAT","GO:0000060~protein import into nucleus, translocation"]
[]
["Annotation Cluster 8","Enrichment Score: 4.8276075851518145","Annotation Cluster 8","Enrichment Score: 4.275706336216338"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0043232~intracellular non-membrane-bounded organelle","GOTERM_CC_FAT","GO:0043232~intracellular non-membrane-bounded organelle"]
["GOTERM_CC_FAT","GO:0043228~non-membrane-bounded organelle","GOTERM_CC_FAT","GO:0043228~non-membrane-bounded organelle"]
["GOTERM_CC_FAT","GO:0005856~cytoskeleton","GOTERM_CC_FAT","GO:0005856~cytoskeleton"]
[]
["Annotation Cluster 9","Enrichment Score: 4.306310942485508","Annotation Cluster 10","Enrichment Score: 3.947767787814929"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","cell cycle","SP_PIR_KEYWORDS","cell cycle"]
["SP_PIR_KEYWORDS","cell division","SP_PIR_KEYWORDS","cell division"]
["GOTERM_BP_FAT","GO:0051301~cell division","GOTERM_BP_FAT","GO:0051301~cell division"]
["GOTERM_BP_FAT","GO:0007049~cell cycle","GOTERM_BP_FAT","GO:0007049~cell cycle"]
["SP_PIR_KEYWORDS","mitosis","SP_PIR_KEYWORDS","mitosis"]
["GOTERM_BP_FAT","GO:0000278~mitotic cell cycle","GOTERM_BP_FAT","GO:0000278~mitotic cell cycle"]
["GOTERM_BP_FAT","GO:0022402~cell cycle process","GOTERM_BP_FAT","GO:0022402~cell cycle process"]
["GOTERM_BP_FAT","GO:0022403~cell cycle phase","GOTERM_BP_FAT","GO:0022403~cell cycle phase"]
["GOTERM_BP_FAT","GO:0000279~M phase","GOTERM_BP_FAT","GO:0000279~M phase"]
["GOTERM_BP_FAT","GO:0000280~nuclear division","GOTERM_BP_FAT","GO:0000280~nuclear division"]
["GOTERM_BP_FAT","GO:0007067~mitosis","GOTERM_BP_FAT","GO:0007067~mitosis"]
["GOTERM_BP_FAT","GO:0000087~M phase of mitotic cell cycle","GOTERM_BP_FAT","GO:0048285~organelle fission"]
["GOTERM_BP_FAT","GO:0048285~organelle fission","GOTERM_BP_FAT","GO:0000087~M phase of mitotic cell cycle"]
[]
["Annotation Cluster 10","Enrichment Score: 4.11694075325209","Annotation Cluster 13","Enrichment Score: 3.5745792758300854"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0015629~actin cytoskeleton","GOTERM_CC_FAT","GO:0015629~actin cytoskeleton"]
["GOTERM_MF_FAT","GO:0008092~cytoskeletal protein binding","GOTERM_MF_FAT","GO:0008092~cytoskeletal protein binding"]
["GOTERM_MF_FAT","GO:0003779~actin binding","GOTERM_MF_FAT","GO:0003779~actin binding"]
["SP_PIR_KEYWORDS","actin-binding","SP_PIR_KEYWORDS","actin-binding"]
[]
["Annotation Cluster 11","Enrichment Score: 3.940502418225576","Annotation Cluster 19","Enrichment Score: 3.183944860157464"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","Chaperone","SP_PIR_KEYWORDS","Chaperone"]
["GOTERM_BP_FAT","GO:0006457~protein folding","GOTERM_BP_FAT","GO:0006457~protein folding"]
["GOTERM_MF_FAT","GO:0051082~unfolded protein binding","GOTERM_MF_FAT","GO:0051082~unfolded protein binding"]
[]
["Annotation Cluster 12","Enrichment Score: 3.898819182524995","Annotation Cluster 11","Enrichment Score: 3.8450994900574686"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0001525~angiogenesis","GOTERM_BP_FAT","GO:0001525~angiogenesis"]
["GOTERM_BP_FAT","GO:0001568~blood vessel development","GOTERM_BP_FAT","GO:0001568~blood vessel development"]
["GOTERM_BP_FAT","GO:0001944~vasculature development","GOTERM_BP_FAT","GO:0048514~blood vessel morphogenesis"]
["GOTERM_BP_FAT","GO:0048514~blood vessel morphogenesis","GOTERM_BP_FAT","GO:0001944~vasculature development"]
[]
["Annotation Cluster 13","Enrichment Score: 3.7332359784329774","Annotation Cluster 12","Enrichment Score: 3.686459912803887"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","ubl conjugation","SP_PIR_KEYWORDS","ubl conjugation"]
["UP_SEQ_FEATURE","cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","SP_PIR_KEYWORDS","isopeptide bond"]
["SP_PIR_KEYWORDS","isopeptide bond","UP_SEQ_FEATURE","cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"]
[]
["Annotation Cluster 14","Enrichment Score: 3.6774479494107757","Annotation Cluster 15","Enrichment Score: 3.442498967367182"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","endoplasmic reticulum","SP_PIR_KEYWORDS","endoplasmic reticulum"]
["GOTERM_CC_FAT","GO:0005783~endoplasmic reticulum","GOTERM_CC_FAT","GO:0005783~endoplasmic reticulum"]
["GOTERM_CC_FAT","GO:0044432~endoplasmic reticulum part","GOTERM_CC_FAT","GO:0044432~endoplasmic reticulum part"]
[]
["Annotation Cluster 15","Enrichment Score: 3.629797039666349"]
["Category","Term"]
["UP_SEQ_FEATURE","domain:UBA"]
["INTERPRO","IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote"]
["SMART","SM00165:UBA"]
["INTERPRO","IPR000449:Ubiquitin-associated/translation elongation factor EF1B, N-terminal"]
[]
["Annotation Cluster 16","Enrichment Score: 3.555122035791796","Annotation Cluster 9","Enrichment Score: 3.9537381331027617"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0006351~transcription, DNA-dependent","GOTERM_BP_FAT","GO:0006351~transcription, DNA-dependent"]
["GOTERM_BP_FAT","GO:0032774~RNA biosynthetic process","GOTERM_BP_FAT","GO:0032774~RNA biosynthetic process"]
["GOTERM_BP_FAT","GO:0006366~transcription from RNA polymerase II promoter","GOTERM_BP_FAT","GO:0006366~transcription from RNA polymerase II promoter"]
[]
["Annotation Cluster 17","Enrichment Score: 3.522601470464901","Annotation Cluster 17","Enrichment Score: 3.2207542111226024"]
["Category","Term","Category","Term"]
["GOTERM_MF_FAT","GO:0060589~nucleoside-triphosphatase regulator activity","GOTERM_MF_FAT","GO:0060589~nucleoside-triphosphatase regulator activity"]
["GOTERM_MF_FAT","GO:0030695~GTPase regulator activity","GOTERM_MF_FAT","GO:0030695~GTPase regulator activity"]
["GOTERM_MF_FAT","GO:0008047~enzyme activator activity","GOTERM_MF_FAT","GO:0008047~enzyme activator activity"]
["GOTERM_MF_FAT","GO:0005096~GTPase activator activity","GOTERM_BP_FAT","GO:0051056~regulation of small GTPase mediated signal transduction"]
["SP_PIR_KEYWORDS","GTPase activation","GOTERM_MF_FAT","GO:0005096~GTPase activator activity"]
["GOTERM_BP_FAT","GO:0051056~regulation of small GTPase mediated signal transduction","SP_PIR_KEYWORDS","GTPase activation"]
["GOTERM_MF_FAT","GO:0005083~small GTPase regulator activity","GOTERM_MF_FAT","GO:0005083~small GTPase regulator activity"]
["GOTERM_BP_FAT","GO:0046578~regulation of Ras protein signal transduction","GOTERM_BP_FAT","GO:0046578~regulation of Ras protein signal transduction"]
["GOTERM_MF_FAT","GO:0005099~Ras GTPase activator activity","GOTERM_BP_FAT","GO:0043087~regulation of GTPase activity"]
["GOTERM_BP_FAT","GO:0043087~regulation of GTPase activity"]
["GOTERM_BP_FAT","GO:0032318~regulation of Ras GTPase activity"]
[]
["Annotation Cluster 18","Enrichment Score: 3.033161582033721","Annotation Cluster 18","Enrichment Score: 3.215404832142555"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0030017~sarcomere","GOTERM_CC_FAT","GO:0030017~sarcomere"]
["GOTERM_CC_FAT","GO:0030016~myofibril","GOTERM_CC_FAT","GO:0030016~myofibril"]
["GOTERM_CC_FAT","GO:0043292~contractile fiber","GOTERM_CC_FAT","GO:0043292~contractile fiber"]
["GOTERM_CC_FAT","GO:0044449~contractile fiber part","GOTERM_CC_FAT","GO:0044449~contractile fiber part"]
["GOTERM_CC_FAT","GO:0030018~Z disc","GOTERM_CC_FAT","GO:0030018~Z disc"]
["GOTERM_CC_FAT","GO:0031674~I band","GOTERM_CC_FAT","GO:0031674~I band"]
[]
["Annotation Cluster 19","Enrichment Score: 3.0069471791902953"]
["Category","Term"]
["SP_PIR_KEYWORDS","cytoplasmic vesicle"]
["GOTERM_CC_FAT","GO:0031410~cytoplasmic vesicle"]
["GOTERM_CC_FAT","GO:0031982~vesicle"]
["GOTERM_CC_FAT","GO:0031988~membrane-bounded vesicle"]
["GOTERM_CC_FAT","GO:0016023~cytoplasmic membrane-bounded vesicle"]
[]
[">>>>>>"]
["Annotation Cluster 21","Enrichment Score: 2.851976052591521","Annotation Cluster 36","Enrichment Score: 2.1420447333660166"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0005912~adherens junction","GOTERM_CC_FAT","GO:0005912~adherens junction"]
["GOTERM_CC_FAT","GO:0070161~anchoring junction","GOTERM_CC_FAT","GO:0016323~basolateral plasma membrane"]
["GOTERM_CC_FAT","GO:0016323~basolateral plasma membrane","GOTERM_CC_FAT","GO:0070161~anchoring junction"]
["GOTERM_CC_FAT","GO:0030055~cell-substrate junction","GOTERM_CC_FAT","GO:0030055~cell-substrate junction"]
["GOTERM_CC_FAT","GO:0005925~focal adhesion","GOTERM_CC_FAT","GO:0005925~focal adhesion"]
["GOTERM_CC_FAT","GO:0005924~cell-substrate adherens junction","GOTERM_CC_FAT","GO:0005924~cell-substrate adherens junction"]
[]
["Annotation Cluster 22","Enrichment Score: 2.821240332460669","Annotation Cluster 20","Enrichment Score: 2.9799297058777503"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0032268~regulation of cellular protein metabolic process","GOTERM_BP_FAT","GO:0032268~regulation of cellular protein metabolic process"]
["GOTERM_BP_FAT","GO:0031399~regulation of protein modification process","GOTERM_BP_FAT","GO:0031399~regulation of protein modification process"]
["GOTERM_BP_FAT","GO:0043161~proteasomal ubiquitin-dependent protein catabolic process","GOTERM_BP_FAT","GO:0010498~proteasomal protein catabolic process"]
["GOTERM_BP_FAT","GO:0010498~proteasomal protein catabolic process","GOTERM_BP_FAT","GO:0043161~proteasomal ubiquitin-dependent protein catabolic process"]
["GOTERM_BP_FAT","GO:0031400~negative regulation of protein modification process","GOTERM_BP_FAT","GO:0031400~negative regulation of protein modification process"]
["GOTERM_BP_FAT","GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle","GOTERM_BP_FAT","GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle"]
["GOTERM_BP_FAT","GO:0032270~positive regulation of cellular protein metabolic process","GOTERM_BP_FAT","GO:0051247~positive regulation of protein metabolic process"]
["GOTERM_BP_FAT","GO:0051247~positive regulation of protein metabolic process","GOTERM_BP_FAT","GO:0032270~positive regulation of cellular protein metabolic process"]
["GOTERM_BP_FAT","GO:0051340~regulation of ligase activity","GOTERM_BP_FAT","GO:0051340~regulation of ligase activity"]
["GOTERM_BP_FAT","GO:0051436~negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle","GOTERM_BP_FAT","GO:0051438~regulation of ubiquitin-protein ligase activity"]
["GOTERM_BP_FAT","GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process","GOTERM_BP_FAT","GO:0051436~negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle"]
["GOTERM_BP_FAT","GO:0051438~regulation of ubiquitin-protein ligase activity","GOTERM_BP_FAT","GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process"]
["GOTERM_BP_FAT","GO:0032269~negative regulation of cellular protein metabolic process","GOTERM_BP_FAT","GO:0051352~negative regulation of ligase activity"]
["GOTERM_BP_FAT","GO:0051444~negative regulation of ubiquitin-protein ligase activity","GOTERM_BP_FAT","GO:0051444~negative regulation of ubiquitin-protein ligase activity"]
["GOTERM_BP_FAT","GO:0051352~negative regulation of ligase activity","GOTERM_BP_FAT","GO:0032269~negative regulation of cellular protein metabolic process"]
["GOTERM_BP_FAT","GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle","GOTERM_BP_FAT","GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle"]
["GOTERM_BP_FAT","GO:0051351~positive regulation of ligase activity","GOTERM_BP_FAT","GO:0051351~positive regulation of ligase activity"]
["GOTERM_BP_FAT","GO:0051248~negative regulation of protein metabolic process","GOTERM_BP_FAT","GO:0031397~negative regulation of protein ubiquitination"]
["GOTERM_BP_FAT","GO:0031401~positive regulation of protein modification process","GOTERM_BP_FAT","GO:0043086~negative regulation of catalytic activity"]
["GOTERM_BP_FAT","GO:0031397~negative regulation of protein ubiquitination","GOTERM_BP_FAT","GO:0051443~positive regulation of ubiquitin-protein ligase activity"]
["GOTERM_BP_FAT","GO:0051443~positive regulation of ubiquitin-protein ligase activity","GOTERM_BP_FAT","GO:0031401~positive regulation of protein modification process"]
["GOTERM_BP_FAT","GO:0043086~negative regulation of catalytic activity","GOTERM_BP_FAT","GO:0051248~negative regulation of protein metabolic process"]
["GOTERM_BP_FAT","GO:0031396~regulation of protein ubiquitination","GOTERM_BP_FAT","GO:0031396~regulation of protein ubiquitination"]
["SP_PIR_KEYWORDS","proteasome","SP_PIR_KEYWORDS","proteasome"]
["GOTERM_BP_FAT","GO:0031398~positive regulation of protein ubiquitination","GOTERM_BP_FAT","GO:0031398~positive regulation of protein ubiquitination"]
["GOTERM_CC_FAT","GO:0000502~proteasome complex","GOTERM_CC_FAT","GO:0000502~proteasome complex"]
["KEGG_PATHWAY","hsa03050:Proteasome","KEGG_PATHWAY","hsa03050:Proteasome"]
[]
["Annotation Cluster 23","Enrichment Score: 2.7521770999290687"]
["Category","Term"]
["UP_SEQ_FEATURE","repeat:WD 3"]
["UP_SEQ_FEATURE","repeat:WD 4"]
["UP_SEQ_FEATURE","repeat:WD 1"]
["UP_SEQ_FEATURE","repeat:WD 2"]
["SP_PIR_KEYWORDS","wd repeat"]
["UP_SEQ_FEATURE","repeat:WD 5"]
["INTERPRO","IPR015943:WD40/YVTN repeat-like"]
["INTERPRO","IPR019781:WD40 repeat, subgroup"]
["INTERPRO","IPR001680:WD40 repeat"]
["SMART","SM00320:WD40"]
["INTERPRO","IPR019782:WD40 repeat 2"]
["INTERPRO","IPR017986:WD40 repeat, region"]
["INTERPRO","IPR019775:WD40 repeat, conserved site"]
["UP_SEQ_FEATURE","repeat:WD 6"]
["UP_SEQ_FEATURE","repeat:WD 7"]
[]
["Annotation Cluster 24","Enrichment Score: 2.699709815301885","Annotation Cluster 31","Enrichment Score: 2.3089776840211704"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","cytoskeleton","SP_PIR_KEYWORDS","cytoskeleton"]
["GOTERM_CC_FAT","GO:0005856~cytoskeleton","GOTERM_CC_FAT","GO:0005856~cytoskeleton"]
["GOTERM_CC_FAT","GO:0015630~microtubule cytoskeleton","GOTERM_CC_FAT","GO:0015630~microtubule cytoskeleton"]
["GOTERM_CC_FAT","GO:0044430~cytoskeletal part","GOTERM_CC_FAT","GO:0044430~cytoskeletal part"]
[]
["Annotation Cluster 25","Enrichment Score: 2.6971033727792264","Annotation Cluster 23","Enrichment Score: 2.6820355727189282"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0010941~regulation of cell death","GOTERM_BP_FAT","GO:0016265~death"]
["GOTERM_BP_FAT","GO:0043067~regulation of programmed cell death","GOTERM_BP_FAT","GO:0008219~cell death"]
["GOTERM_BP_FAT","GO:0042981~regulation of apoptosis","SP_PIR_KEYWORDS","Apoptosis"]
["GOTERM_BP_FAT","GO:0010942~positive regulation of cell death","GOTERM_BP_FAT","GO:0006915~apoptosis"]
["GOTERM_BP_FAT","GO:0043065~positive regulation of apoptosis","GOTERM_BP_FAT","GO:0012501~programmed cell death"]
["GOTERM_BP_FAT","GO:0043068~positive regulation of programmed cell death"]
["GOTERM_BP_FAT","GO:0060548~negative regulation of cell death"]
["GOTERM_BP_FAT","GO:0043069~negative regulation of programmed cell death"]
["GOTERM_BP_FAT","GO:0043066~negative regulation of apoptosis"]
["GOTERM_BP_FAT","GO:0006917~induction of apoptosis"]
["GOTERM_BP_FAT","GO:0012502~induction of programmed cell death"]
["GOTERM_BP_FAT","GO:0006916~anti-apoptosis"]
[]
["Annotation Cluster 26","Enrichment Score: 2.6886902036487017","Annotation Cluster 22","Enrichment Score: 2.7183341693942205"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","rna-binding","SP_PIR_KEYWORDS","rna-binding"]
["UP_SEQ_FEATURE","domain:RRM 1","UP_SEQ_FEATURE","domain:RRM 1"]
["UP_SEQ_FEATURE","domain:RRM 2","UP_SEQ_FEATURE","domain:RRM 2"]
["INTERPRO","IPR012677:Nucleotide-binding, alpha-beta plait","INTERPRO","IPR012677:Nucleotide-binding, alpha-beta plait"]
["UP_SEQ_FEATURE","domain:RRM 3","UP_SEQ_FEATURE","domain:RRM 3"]
["INTERPRO","IPR000504:RNA recognition motif, RNP-1","INTERPRO","IPR000504:RNA recognition motif, RNP-1"]
["SMART","SM00360:RRM","SMART","SM00360:RRM"]
["UP_SEQ_FEATURE","domain:RRM","UP_SEQ_FEATURE","domain:RRM"]
[]
["Annotation Cluster 27","Enrichment Score: 2.640048363643001","Annotation Cluster 32","Enrichment Score: 2.273943580686726"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0006461~protein complex assembly","GOTERM_BP_FAT","GO:0006461~protein complex assembly"]
["GOTERM_BP_FAT","GO:0070271~protein complex biogenesis","GOTERM_BP_FAT","GO:0070271~protein complex biogenesis"]
["GOTERM_BP_FAT","GO:0043933~macromolecular complex subunit organization","GOTERM_BP_FAT","GO:0043933~macromolecular complex subunit organization"]
["GOTERM_BP_FAT","GO:0065003~macromolecular complex assembly","GOTERM_BP_FAT","GO:0065003~macromolecular complex assembly"]
["GOTERM_BP_FAT","GO:0043623~cellular protein complex assembly","GOTERM_BP_FAT","GO:0043623~cellular protein complex assembly"]
["GOTERM_BP_FAT","GO:0034621~cellular macromolecular complex subunit organization","GOTERM_BP_FAT","GO:0034621~cellular macromolecular complex subunit organization"]
["GOTERM_BP_FAT","GO:0034622~cellular macromolecular complex assembly","GOTERM_BP_FAT","GO:0034622~cellular macromolecular complex assembly"]
[]
[">>>>>>"]
["Annotation Cluster 31","Enrichment Score: 2.448635833216334","Annotation Cluster 38","Enrichment Score: 2.0745910598176804"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","lysosome","SP_PIR_KEYWORDS","lysosome"]
["GOTERM_CC_FAT","GO:0000323~lytic vacuole","GOTERM_CC_FAT","GO:0005764~lysosome"]
["GOTERM_CC_FAT","GO:0005764~lysosome","GOTERM_CC_FAT","GO:0000323~lytic vacuole"]
["GOTERM_CC_FAT","GO:0005773~vacuole","GOTERM_CC_FAT","GO:0005773~vacuole"]
[]
[">>>>>>>"]
["Annotation Cluster 34","Enrichment Score: 2.4003971442055967"]
["Category","Term"]
["GOTERM_CC_FAT","GO:0031252~cell leading edge"]
["GOTERM_CC_FAT","GO:0030027~lamellipodium"]
["SP_PIR_KEYWORDS","cell projection"]
[]
["Annotation Cluster 35","Enrichment Score: 2.371228037283992","Annotation Cluster 33","Enrichment Score: 2.211392135315361"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0019867~outer membrane","GOTERM_CC_FAT","GO:0019867~outer membrane"]
["GOTERM_CC_FAT","GO:0005741~mitochondrial outer membrane","GOTERM_CC_FAT","GO:0005741~mitochondrial outer membrane"]
["GOTERM_CC_FAT","GO:0031968~organelle outer membrane","GOTERM_CC_FAT","GO:0031968~organelle outer membrane"]
["SP_PIR_KEYWORDS","mitochondrion outer membrane","SP_PIR_KEYWORDS","mitochondrion outer membrane"]
[]
["Annotation Cluster 36","Enrichment Score: 2.2068628399790238","Annotation Cluster 52","Enrichment Score: 1.6651494072583568"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","P-loop","SP_PIR_KEYWORDS","P-loop"]
["SP_PIR_KEYWORDS","nucleotide binding","SP_PIR_KEYWORDS","nucleotide binding"]
["SP_PIR_KEYWORDS","GTP binding","SP_PIR_KEYWORDS","GTP binding"]
[]
[">>>>>>"]
["Annotation Cluster 38","Enrichment Score: 2.083603340956716","Annotation Cluster 41","Enrichment Score: 1.941399867449746"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","translocation","GOTERM_CC_FAT","GO:0046930~pore complex"]
["GOTERM_CC_FAT","GO:0046930~pore complex","SP_PIR_KEYWORDS","translocation"]
["GOTERM_CC_FAT","GO:0005643~nuclear pore","GOTERM_CC_FAT","GO:0005643~nuclear pore"]
["GOTERM_CC_FAT","GO:0005635~nuclear envelope","GOTERM_BP_FAT","GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport"]
["GOTERM_BP_FAT","GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport","GOTERM_CC_FAT","GO:0005635~nuclear envelope"]
["SP_PIR_KEYWORDS","nuclear pore complex","SP_PIR_KEYWORDS","mRNA transport"]
["SP_PIR_KEYWORDS","mRNA transport","SP_PIR_KEYWORDS","nuclear pore complex"]
["GOTERM_BP_FAT","GO:0006403~RNA localization","GOTERM_BP_FAT","GO:0006403~RNA localization"]
["GOTERM_BP_FAT","GO:0051236~establishment of RNA localization","GOTERM_BP_FAT","GO:0050657~nucleic acid transport"]
["GOTERM_BP_FAT","GO:0050657~nucleic acid transport","GOTERM_BP_FAT","GO:0050658~RNA transport"]
["GOTERM_BP_FAT","GO:0050658~RNA transport","GOTERM_BP_FAT","GO:0051236~establishment of RNA localization"]
["GOTERM_BP_FAT","GO:0051028~mRNA transport","GOTERM_BP_FAT","GO:0051028~mRNA transport"]
["GOTERM_BP_FAT","GO:0051168~nuclear export","GOTERM_BP_FAT","GO:0051168~nuclear export"]
["GOTERM_BP_FAT","GO:0006405~RNA export from nucleus","GOTERM_BP_FAT","GO:0006405~RNA export from nucleus"]
["GOTERM_BP_FAT","GO:0006406~mRNA export from nucleus","GOTERM_BP_FAT","GO:0006406~mRNA export from nucleus"]
[]
["Annotation Cluster 39","Enrichment Score: 2.0475593315255805","Annotation Cluster 37","Enrichment Score: 2.1401682874634367"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0010605~negative regulation of macromolecule metabolic process","GOTERM_BP_FAT","GO:0010605~negative regulation of macromolecule metabolic process"]
["GOTERM_BP_FAT","GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process","GOTERM_BP_FAT","GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"]
["GOTERM_BP_FAT","GO:0010629~negative regulation of gene expression","GOTERM_BP_FAT","GO:0010629~negative regulation of gene expression"]
["GOTERM_BP_FAT","GO:0031327~negative regulation of cellular biosynthetic process","GOTERM_BP_FAT","GO:0051172~negative regulation of nitrogen compound metabolic process"]
["GOTERM_BP_FAT","GO:0051172~negative regulation of nitrogen compound metabolic process","GOTERM_BP_FAT","GO:0031327~negative regulation of cellular biosynthetic process"]
["GOTERM_BP_FAT","GO:0009890~negative regulation of biosynthetic process","GOTERM_BP_FAT","GO:0009890~negative regulation of biosynthetic process"]
["GOTERM_BP_FAT","GO:0010558~negative regulation of macromolecule biosynthetic process","GOTERM_BP_FAT","GO:0010558~negative regulation of macromolecule biosynthetic process"]
["GOTERM_BP_FAT","GO:0016481~negative regulation of transcription","GOTERM_BP_FAT","GO:0016481~negative regulation of transcription"]
["GOTERM_MF_FAT","GO:0016564~transcription repressor activity","GOTERM_MF_FAT","GO:0016564~transcription repressor activity"]
["GOTERM_BP_FAT","GO:0045892~negative regulation of transcription, DNA-dependent","GOTERM_BP_FAT","GO:0045892~negative regulation of transcription, DNA-dependent"]
["GOTERM_BP_FAT","GO:0051253~negative regulation of RNA metabolic process","GOTERM_BP_FAT","GO:0051253~negative regulation of RNA metabolic process"]
["GOTERM_BP_FAT","GO:0000122~negative regulation of transcription from RNA polymerase II promoter","GOTERM_BP_FAT","GO:0000122~negative regulation of transcription from RNA polymerase II promoter"]
[]
["Annotation Cluster 40","Enrichment Score: 2.0469174505666947","Annotation Cluster 39","Enrichment Score: 2.0421316749095966"]
["Category","Term","Category","Term"]
["GOTERM_BP_FAT","GO:0010033~response to organic substance","GOTERM_BP_FAT","GO:0010033~response to organic substance"]
["GOTERM_BP_FAT","GO:0032869~cellular response to insulin stimulus","GOTERM_BP_FAT","GO:0032869~cellular response to insulin stimulus"]
["GOTERM_BP_FAT","GO:0009725~response to hormone stimulus","GOTERM_BP_FAT","GO:0009725~response to hormone stimulus"]
["GOTERM_BP_FAT","GO:0009719~response to endogenous stimulus","GOTERM_BP_FAT","GO:0009719~response to endogenous stimulus"]
["GOTERM_BP_FAT","GO:0043434~response to peptide hormone stimulus","GOTERM_BP_FAT","GO:0043434~response to peptide hormone stimulus"]
["GOTERM_BP_FAT","GO:0032868~response to insulin stimulus","GOTERM_BP_FAT","GO:0032868~response to insulin stimulus"]
["GOTERM_BP_FAT","GO:0008286~insulin receptor signaling pathway","GOTERM_BP_FAT","GO:0008286~insulin receptor signaling pathway"]
["GOTERM_BP_FAT","GO:0032870~cellular response to hormone stimulus","GOTERM_BP_FAT","GO:0032870~cellular response to hormone stimulus"]
[]
[">>>>>"]
["Annotation Cluster 49","Enrichment Score: 1.6990372809441265","Annotation Cluster 47","Enrichment Score: 1.8038018166815541"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","ribonucleoprotein","SP_PIR_KEYWORDS","ribonucleoprotein"]
["GOTERM_CC_FAT","GO:0030529~ribonucleoprotein complex","GOTERM_CC_FAT","GO:0030529~ribonucleoprotein complex"]
["SP_PIR_KEYWORDS","ribosomal protein","SP_PIR_KEYWORDS","ribosomal protein"]
["SP_PIR_KEYWORDS","protein biosynthesis","SP_PIR_KEYWORDS","protein biosynthesis"]
["GOTERM_BP_FAT","GO:0006412~translation","GOTERM_BP_FAT","GO:0006412~translation"]
["GOTERM_CC_FAT","GO:0005840~ribosome","GOTERM_CC_FAT","GO:0005840~ribosome"]
["GOTERM_CC_FAT","GO:0033279~ribosomal subunit","GOTERM_CC_FAT","GO:0033279~ribosomal subunit"]
["GOTERM_MF_FAT","GO:0003735~structural constituent of ribosome","GOTERM_MF_FAT","GO:0003735~structural constituent of ribosome"]
["GOTERM_CC_FAT","GO:0022626~cytosolic ribosome","GOTERM_CC_FAT","GO:0022626~cytosolic ribosome"]
["GOTERM_CC_FAT","GO:0015934~large ribosomal subunit","GOTERM_CC_FAT","GO:0015934~large ribosomal subunit"]
["GOTERM_CC_FAT","GO:0044445~cytosolic part","SP_PIR_KEYWORDS","ribosome"]
["SP_PIR_KEYWORDS","ribosome","GOTERM_CC_FAT","GO:0022625~cytosolic large ribosomal subunit"]
["GOTERM_CC_FAT","GO:0022625~cytosolic large ribosomal subunit","GOTERM_CC_FAT","GO:0044445~cytosolic part"]
["KEGG_PATHWAY","hsa03010:Ribosome","KEGG_PATHWAY","hsa03010:Ribosome"]
["GOTERM_BP_FAT","GO:0006414~translational elongation","GOTERM_BP_FAT","GO:0006414~translational elongation"]
["GOTERM_CC_FAT","GO:0022627~cytosolic small ribosomal subunit","GOTERM_CC_FAT","GO:0022627~cytosolic small ribosomal subunit"]
[]
[">>>>>>"]
["Annotation Cluster 55","Enrichment Score: 1.6587014058997491"]
["Category","Term"]
["SP_PIR_KEYWORDS","Initiation factor"]
["GOTERM_MF_FAT","GO:0003743~translation initiation factor activity"]
["GOTERM_CC_FAT","GO:0005852~eukaryotic translation initiation factor 3 complex"]
["GOTERM_BP_FAT","GO:0006446~regulation of translational initiation"]
["GOTERM_BP_FAT","GO:0006413~translational initiation"]
["GOTERM_MF_FAT","GO:0008135~translation factor activity, nucleic acid binding"]
[]
[">>>>>>>"]
["Annotation Cluster 57","Enrichment Score: 1.6464887673436543","Annotation Cluster 46","Enrichment Score: 1.8187482291220873"]
["Category","Term","Category","Term"]
["GOTERM_CC_FAT","GO:0000151~ubiquitin ligase complex","GOTERM_CC_FAT","GO:0000151~ubiquitin ligase complex"]
["GOTERM_MF_FAT","GO:0016879~ligase activity, forming carbon-nitrogen bonds","GOTERM_MF_FAT","GO:0016879~ligase activity, forming carbon-nitrogen bonds"]
["GOTERM_MF_FAT","GO:0019787~small conjugating protein ligase activity","GOTERM_MF_FAT","GO:0019787~small conjugating protein ligase activity"]
["GOTERM_MF_FAT","GO:0016881~acid-amino acid ligase activity","GOTERM_MF_FAT","GO:0016881~acid-amino acid ligase activity"]
["GOTERM_BP_FAT","GO:0070647~protein modification by small protein conjugation or removal","GOTERM_BP_FAT","GO:0070647~protein modification by small protein conjugation or removal"]
["GOTERM_BP_FAT","GO:0032446~protein modification by small protein conjugation","GOTERM_BP_FAT","GO:0032446~protein modification by small protein conjugation"]
["GOTERM_MF_FAT","GO:0004842~ubiquitin-protein ligase activity","GOTERM_MF_FAT","GO:0004842~ubiquitin-protein ligase activity"]
["GOTERM_BP_FAT","GO:0016567~protein ubiquitination","GOTERM_BP_FAT","GO:0016567~protein ubiquitination"]
[]
[">>>>>>"]
["Annotation Cluster 61","Enrichment Score: 1.5703660489649756","Annotation Cluster 76","Enrichment Score: 1.392994540099367"]
["Category","Term","Category","Term"]
["SP_PIR_KEYWORDS","tyrosine-protein kinase","SP_PIR_KEYWORDS","tyrosine-protein kinase"]
["GOTERM_MF_FAT","GO:0004713~protein tyrosine kinase activity","GOTERM_MF_FAT","GO:0004713~protein tyrosine kinase activity"]
["GOTERM_MF_FAT","GO:0004715~non-membrane spanning protein tyrosine kinase activity","GOTERM_MF_FAT","GO:0004715~non-membrane spanning protein tyrosine kinase activity"]
["INTERPRO","IPR008266:Tyrosine protein kinase, active site","INTERPRO","IPR008266:Tyrosine protein kinase, active site"]
["INTERPRO","IPR001245:Tyrosine protein kinase","INTERPRO","IPR001245:Tyrosine protein kinase"]
["SMART","SM00219:TyrKc","SMART","SM00219:TyrKc"]
["SP_PIR_KEYWORDS","tyrosine-specific protein kinase","SP_PIR_KEYWORDS","tyrosine-specific protein kinase"]
["GOTERM_MF_FAT","GO:0004714~transmembrane receptor protein tyrosine kinase activity","GOTERM_MF_FAT","GO:0004714~transmembrane receptor protein tyrosine kinase activity"]
[]
[">>>>>"]
["Annotation Cluster 126","Enrichment Score: 1.028769587559216","Annotation Cluster 61","Enrichment Score: 1.5511507980726202",{"$nulls":4},">>>>>"]
["Category","Term","Category","Term",{"$nulls":4},"Annotation Cluster 2","Enrichment Score: 1.0677884919945666"]
["SP_PIR_KEYWORDS","muscle protein","SP_PIR_KEYWORDS","muscle protein",{"$nulls":4},"Category","Term"]
["GOTERM_CC_FAT","GO:0016459~myosin complex","GOTERM_CC_FAT","GO:0016459~myosin complex",{"$nulls":4},"KEGG_PATHWAY","hsa04080:Neuroactive ligand-receptor interaction"]
["GOTERM_MF_FAT","GO:0008307~structural constituent of muscle","GOTERM_MF_FAT","GO:0008307~structural constituent of muscle",{"$nulls":4},"GOTERM_MF_FAT","GO:0030594~neurotransmitter receptor activity"]
["GOTERM_CC_FAT","GO:0005859~muscle myosin complex","GOTERM_CC_FAT","GO:0005859~muscle myosin complex",{"$nulls":4},"GOTERM_MF_FAT","GO:0042165~neurotransmitter binding"]
["GOTERM_CC_FAT","GO:0016460~myosin II complex","GOTERM_CC_FAT","GO:0016460~myosin II complex",{"$nulls":4},"GOTERM_MF_FAT","GO:0042277~peptide binding"]
["GOTERM_CC_FAT","GO:0005863~striated muscle thick filament","Annotation Cluster 35","Enrichment Score: 2.1537277245714708",{"$nulls":4},"GOTERM_CC_FAT","GO:0005887~integral to plasma membrane"]
["SP_PIR_KEYWORDS","thick filament","Category","Term",{"$nulls":4},"GOTERM_CC_FAT","GO:0031226~intrinsic to plasma membrane"]
["GOTERM_CC_FAT","GO:0032982~myosin filament","SP_PIR_KEYWORDS","muscle protein",{"$nulls":4},"UP_SEQ_FEATURE","topological domain:Extracellular"]
[null,null,"GOTERM_BP_FAT","GO:0006941~striated muscle contraction",{"$nulls":4},"UP_SEQ_FEATURE","topological domain:Cytoplasmic"]
[null,null,"GOTERM_BP_FAT","GO:0006936~muscle contraction",{"$nulls":4},"SP_PIR_KEYWORDS","receptor"]
[null,null,"GOTERM_BP_FAT","GO:0003012~muscle system process",{"$nulls":4},"GOTERM_CC_FAT","GO:0044459~plasma membrane part"]
[{"$nulls":8},"GOTERM_BP_FAT","GO:0007186~G-protein coupled receptor protein signaling pathway"]
[{"$nulls":8},"PIR_SUPERFAMILY","PIRSF800006:rhodopsin-like G protein-coupled receptors"]
[null,null,"Annotation Cluster 14","Enrichment Score: 3.555649990771239",{"$nulls":4},"INTERPRO","IPR017452:GPCR, rhodopsin-like superfamily"]
[null,null,"Category","Term",{"$nulls":4},"INTERPRO","IPR000276:7TM GPCR, rhodopsin-like"]
[null,null,"GOTERM_BP_FAT","GO:0018212~peptidyl-tyrosine modification",{"$nulls":4},"GOTERM_BP_FAT","GO:0007166~cell surface receptor linked signal transduction"]
[null,null,"GOTERM_BP_FAT","GO:0018108~peptidyl-tyrosine phosphorylation",{"$nulls":4},"SP_PIR_KEYWORDS","g-protein coupled receptor"]
[null,null,"SP_PIR_KEYWORDS","tyrosine-protein kinase",{"$nulls":4},"SP_PIR_KEYWORDS","transducer"]
[{"$nulls":8},"GOTERM_CC_FAT","GO:0005886~plasma membrane"]
[null,null,"Annotation Cluster 48","Enrichment Score: 1.7940151172060266",{"$nulls":4},"SP_PIR_KEYWORDS","cell membrane"]
[null,null,"Category","Term"]
[null,null,"GOTERM_BP_FAT","GO:0010604~positive regulation of macromolecule metabolic process",{"$nulls":4},">>>>>"]
[null,null,"GOTERM_BP_FAT","GO:0010557~positive regulation of macromolecule biosynthetic process",{"$nulls":4},"Annotation Cluster 4","Enrichment Score: 0.9436244502557725"]
[null,null,"GOTERM_BP_FAT","GO:0051173~positive regulation of nitrogen compound metabolic process",{"$nulls":4},"Category","Term"]
[null,null,"GOTERM_BP_FAT","GO:0045941~positive regulation of transcription",{"$nulls":4},"KEGG_PATHWAY","hsa04080:Neuroactive ligand-receptor interaction"]
[null,null,"GOTERM_BP_FAT","GO:0009891~positive regulation of biosynthetic process",{"$nulls":4},"GOTERM_MF_FAT","GO:0005230~extracellular ligand-gated ion channel activity"]
[null,null,"GOTERM_BP_FAT","GO:0051254~positive regulation of RNA metabolic process",{"$nulls":4},"GOTERM_MF_FAT","GO:0022834~ligand-gated channel activity"]
[null,null,"GOTERM_BP_FAT","GO:0031328~positive regulation of cellular biosynthetic process",{"$nulls":4},"GOTERM_MF_FAT","GO:0015276~ligand-gated ion channel activity"]
[null,null,"GOTERM_BP_FAT","GO:0045893~positive regulation of transcription, DNA-dependent",{"$nulls":4},"GOTERM_CC_FAT","GO:0045211~postsynaptic membrane"]
[null,null,"GOTERM_BP_FAT","GO:0010628~positive regulation of gene expression",{"$nulls":4},"GOTERM_CC_FAT","GO:0044456~synapse part"]
[null,null,"GOTERM_BP_FAT","GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process",{"$nulls":4},"GOTERM_MF_FAT","GO:0022836~gated channel activity"]
[null,null,"GOTERM_MF_FAT","GO:0016563~transcription activator activity",{"$nulls":4},"SP_PIR_KEYWORDS","ionic channel"]
[null,null,"GOTERM_BP_FAT","GO:0006357~regulation of transcription from RNA polymerase II promoter",{"$nulls":4},"SP_PIR_KEYWORDS","ion transport"]
[null,null,"GOTERM_BP_FAT","GO:0045944~positive regulation of transcription from RNA polymerase II promoter",{"$nulls":4},"GOTERM_MF_FAT","GO:0005216~ion channel activity"]
[null,null,"GOTERM_BP_FAT","GO:0051252~regulation of RNA metabolic process",{"$nulls":4},"GOTERM_MF_FAT","GO:0022838~substrate specific channel activity"]
[null,null,"GOTERM_BP_FAT","GO:0006355~regulation of transcription, DNA-dependent",{"$nulls":4},"GOTERM_CC_FAT","GO:0045202~synapse"]
[{"$nulls":8},"GOTERM_MF_FAT","GO:0015267~channel activity"]
[{"$nulls":8},"GOTERM_MF_FAT","GO:0022803~passive transmembrane transporter activity"]
[{"$nulls":8},"GOTERM_BP_FAT","GO:0006811~ion transport"]