<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-00708293</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T14:33:45+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.</title>
            <author role="aut">
              <persName>
                <forename type="first">Yuna</forename>
                <surname>Kim</surname>
              </persName>
              <idno type="halauthorid">181349-0</idno>
              <affiliation ref="#struct-194276"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Akio</forename>
                <surname>Kobayashi</surname>
              </persName>
              <idno type="halauthorid">642112-0</idno>
              <affiliation ref="#struct-194277"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ryohei</forename>
                <surname>Sekido</surname>
              </persName>
              <idno type="halauthorid">642113-0</idno>
              <affiliation ref="#struct-194278"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Leo</forename>
                <surname>Dinapoli</surname>
              </persName>
              <idno type="halauthorid">642114-0</idno>
              <affiliation ref="#struct-194276"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jennifer</forename>
                <surname>Brennan</surname>
              </persName>
              <idno type="halauthorid">642115-0</idno>
              <affiliation ref="#struct-194276"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Christine</forename>
                <surname>Chaboissier</surname>
              </persName>
              <email type="md5">7c318e605054d346aef029949a075ab8</email>
              <email type="domain">unice.fr</email>
              <idno type="idhal" notation="string">marie-christine-chaboissier</idno>
              <idno type="idhal" notation="numeric">738830</idno>
              <idno type="halauthorid" notation="string">14792-738830</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0934-8217</idno>
              <idno type="IDREF">https://www.idref.fr/167921592</idno>
              <affiliation ref="#struct-94962"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Francis</forename>
                <surname>Poulat</surname>
              </persName>
              <email type="md5">260d4552add5e5f3e22b4fc4d052a9de</email>
              <email type="domain">igh.cnrs.fr</email>
              <idno type="idhal" notation="numeric">1117392</idno>
              <idno type="halauthorid" notation="string">193411-1117392</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2070-1296</idno>
              <idno type="IDREF">https://www.idref.fr/19770302X</idno>
              <affiliation ref="#struct-425"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Richard</forename>
                <forename type="middle">R.</forename>
                <surname>Behringer</surname>
              </persName>
              <idno type="halauthorid">642116-0</idno>
              <affiliation ref="#struct-194277"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Robin</forename>
                <surname>Lovell-Badge</surname>
              </persName>
              <idno type="halauthorid">546886-0</idno>
              <affiliation ref="#struct-194278"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Blanche</forename>
                <surname>Capel</surname>
              </persName>
              <email type="md5">ac95d5bdf6c92f5353aa35c251085906</email>
              <email type="domain">cellbio.duke.edu</email>
              <idno type="idhal" notation="numeric">926327</idno>
              <idno type="halauthorid" notation="string">642117-926327</idno>
              <affiliation ref="#struct-194276"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Delphine</forename>
                <surname>Autard</surname>
              </persName>
              <email type="md5">f048e2cc60ba3ff0d2a63cd993824e0f</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>This work was funded by grants from the National Institutes of Health to BC (HD39963), and to RRB (HD30284).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2012-06-15 09:16:03</date>
              <date type="whenModified">2026-02-19 13:18:44</date>
              <date type="whenReleased">2012-06-14 15:20:06</date>
              <date type="whenProduced">2006-06</date>
              <date type="whenEndEmbargoed">2012-06-15</date>
              <ref type="file" target="https://inserm.hal.science/inserm-00708293v1/document">
                <date notBefore="2012-06-15"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://inserm.hal.science/inserm-00708293v1/file/journal.pbio.0040187.pdf" id="file-708293-89657">
                <date notBefore="2012-06-15"/>
              </ref>
              <ref type="externalLink" target="https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040187&amp;type=printable"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="110394">
                <persName>
                  <forename>Delphine</forename>
                  <surname>Autard</surname>
                </persName>
                <email type="md5">f048e2cc60ba3ff0d2a63cd993824e0f</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00708293</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-00708293</idno>
            <idno type="halBibtex">kim:inserm-00708293</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS Biology&lt;/i&gt;, 2006, 4 (6), pp.e187. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.pbio.0040187"&gt;&amp;#x27E8;10.1371/journal.pbio.0040187&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS Biology, 2006, 4 (6), pp.e187. &amp;#x27E8;10.1371/journal.pbio.0040187&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-708293-89657"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGH" corresp="UNIV-MONTPELLIER">Institut de génétique humaine</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Yuna</forename>
                    <surname>Kim</surname>
                  </persName>
                  <idno type="halauthorid">181349-0</idno>
                  <affiliation ref="#struct-194276"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Akio</forename>
                    <surname>Kobayashi</surname>
                  </persName>
                  <idno type="halauthorid">642112-0</idno>
                  <affiliation ref="#struct-194277"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ryohei</forename>
                    <surname>Sekido</surname>
                  </persName>
                  <idno type="halauthorid">642113-0</idno>
                  <affiliation ref="#struct-194278"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Leo</forename>
                    <surname>Dinapoli</surname>
                  </persName>
                  <idno type="halauthorid">642114-0</idno>
                  <affiliation ref="#struct-194276"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jennifer</forename>
                    <surname>Brennan</surname>
                  </persName>
                  <idno type="halauthorid">642115-0</idno>
                  <affiliation ref="#struct-194276"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Christine</forename>
                    <surname>Chaboissier</surname>
                  </persName>
                  <email type="md5">7c318e605054d346aef029949a075ab8</email>
                  <email type="domain">unice.fr</email>
                  <idno type="idhal" notation="string">marie-christine-chaboissier</idno>
                  <idno type="idhal" notation="numeric">738830</idno>
                  <idno type="halauthorid" notation="string">14792-738830</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0934-8217</idno>
                  <idno type="IDREF">https://www.idref.fr/167921592</idno>
                  <affiliation ref="#struct-94962"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Francis</forename>
                    <surname>Poulat</surname>
                  </persName>
                  <email type="md5">260d4552add5e5f3e22b4fc4d052a9de</email>
                  <email type="domain">igh.cnrs.fr</email>
                  <idno type="idhal" notation="numeric">1117392</idno>
                  <idno type="halauthorid" notation="string">193411-1117392</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2070-1296</idno>
                  <idno type="IDREF">https://www.idref.fr/19770302X</idno>
                  <affiliation ref="#struct-425"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Richard</forename>
                    <forename type="middle">R.</forename>
                    <surname>Behringer</surname>
                  </persName>
                  <idno type="halauthorid">642116-0</idno>
                  <affiliation ref="#struct-194277"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Robin</forename>
                    <surname>Lovell-Badge</surname>
                  </persName>
                  <idno type="halauthorid">546886-0</idno>
                  <affiliation ref="#struct-194278"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Blanche</forename>
                    <surname>Capel</surname>
                  </persName>
                  <email type="md5">ac95d5bdf6c92f5353aa35c251085906</email>
                  <email type="domain">cellbio.duke.edu</email>
                  <idno type="idhal" notation="numeric">926327</idno>
                  <idno type="halauthorid" notation="string">642117-926327</idno>
                  <affiliation ref="#struct-194276"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">1954</idno>
                <idno type="issn">1544-9173</idno>
                <idno type="eissn">1545-7885</idno>
                <title level="j">PLoS Biology</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">4</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">e187</biblScope>
                  <date type="datePub">2006-06</date>
                  <date type="dateEpub">2006-05-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pbio.0040187</idno>
              <idno type="pubmed">16700629</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">SOX9 Transcription Factor</classCode>
              <classCode scheme="mesh">Sex Determination Processes</classCode>
              <classCode scheme="mesh">Sex-Determining Region Y Protein</classCode>
              <classCode scheme="mesh">Signal Transduction</classCode>
              <classCode scheme="mesh">Transcription Factors</classCode>
              <classCode scheme="mesh">Wnt Proteins</classCode>
              <classCode scheme="mesh">Wnt4 Protein</classCode>
              <classCode scheme="mesh">Fibroblast Growth Factor 9</classCode>
              <classCode scheme="mesh">Gene Expression Regulation, Developmental</classCode>
              <classCode scheme="mesh">Gonads</classCode>
              <classCode scheme="mesh">High Mobility Group Proteins</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Mutation</classCode>
              <classCode scheme="mesh">Proto-Oncogene Proteins</classCode>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development. In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination. Loss of Fgf9 leads to XY sex reversal, whereas loss of Wnt4 results in partial testis development in XX gonads. However, the relationship between these signals and the male sex-determining gene, Sry, was unknown. We show through gain- and loss-of-function experiments that fibroblast growth factor 9 (FGF9) and WNT4 act as opposing signals to regulate sex determination. In the mouse XY gonad, Sry normally initiates a feed-forward loop between Sox9 and Fgf9, which up-regulates Fgf9 and represses Wnt4 to establish the testis pathway. Surprisingly, loss of Wnt4 in XX gonads is sufficient to up-regulate Fgf9 and Sox9 in the absence of Sry. These data suggest that the fate of the gonad is controlled by antagonism between Fgf9 and Wnt4. The role of the male sex-determining switch--Sry in the case of mammals--is to tip the balance between these underlying patterning signals. In principle, sex determination in other vertebrates may operate through any switch that introduces an imbalance between these two signaling pathways.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-194276" status="INCOMING">
          <orgName>Department of Cell Biology</orgName>
          <desc>
            <address>
              <addrLine>Durham, North Carolina</addrLine>
              <country key="US"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-451889" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-194277" status="INCOMING">
          <orgName>Department of Molecular Genetics</orgName>
          <desc>
            <address>
              <addrLine>Houston, Texas</addrLine>
              <country key="US"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-348205" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-194278" status="INCOMING">
          <orgName>Division of Developmental Genetics</orgName>
          <desc>
            <address>
              <addrLine>London</addrLine>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-344148" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-94962" status="OLD">
          <orgName>Génétique moléculaire de la différenciation et du développement</orgName>
          <desc>
            <address>
              <addrLine>Parc Valrose 06108, Nice cedex 2</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="U470" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-425" status="OLD">
          <idno type="ISNI">0000000098865504</idno>
          <idno type="RNSR">201722404H</idno>
          <idno type="ROR">https://ror.org/05ee10k25</idno>
          <orgName>Institut de génétique humaine</orgName>
          <orgName type="acronym">IGH</orgName>
          <date type="start">1998-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igh.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR9002 / UPR1142" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-451889" status="VALID">
          <idno type="ROR">https://ror.org/04bct7p84</idno>
          <orgName>Duke University Medical Center</orgName>
          <desc>
            <address>
              <addrLine>2301 Erwin Rd, Durham, NC 27710</addrLine>
              <country key="US"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-348205" status="INCOMING">
          <orgName>University of Texas M. D. Anderson Cancer Center</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-344148" status="INCOMING">
          <orgName>MRC National Institute for Medical Research</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-117617" status="VALID">
          <idno type="IdRef">026403498</idno>
          <idno type="ISNI">0000000123372892</idno>
          <idno type="ROR">https://ror.org/02k9vew78</idno>
          <orgName>Université Nice Sophia Antipolis (1965 - 2019)</orgName>
          <orgName type="acronym">UNS</orgName>
          <date type="start">1965-10-23</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 06100 Nice</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>