%0 Journal Article %T Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy. %+ Department of Genetics and Evolution %+ Mammalian Oocyte & Embryo Research Laboratory %+ Institut de Génétique et Développement de Rennes (IGDR) %A Polanski, Zbigniew %A Homer, Hayden %A Kubiak, Jacek, Z. %Z In: Jacek Z. KUBIAK, (ed.), 2012, Mouse development: From oocyte to stem cells, Springer Verlag, 69-91. (Results and Problems in Cell Differentiation - 55) %< avec comité de lecture %@ 0080-1844 %J Results and Problems in Cell Differentiation %3 Mouse development: From oocyte to stem cells %Y Jacek Z. Kubiak %I Springer-verlag Berlin Heidelberg %S Results and Problems in Cell Differentiation - 56 %V 55 %P 69-91 %8 2012 %D 2012 %R 10.1007/978-3-642-30406-4_4 %M 22918801 %Z Life Sciences [q-bio]/Reproductive Biology %Z Life Sciences [q-bio]/Development Biology %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X Oocyte maturation and early embryo development require precise coordination between cell cycle progression and the developmental programme. Cyclin B plays a major role in this process: its accumulation and degradation is critical for driving the cell cycle through activation and inactivation of the major cell cycle kinase, CDK1. CDK1 activation is required for M-phase entry whereas its inactivation leads to exit from M-phase. The tempo of oocyte meiotic and embryonic mitotic divisions is set by the rate of cyclin B accumulation and the timing of its destruction. By controlling when cyclin B destruction is triggered and by co-ordinating this with the completion of chromosome alignment, the spindle assembly checkpoint (SAC) is a critical quality control system important for averting aneuploidy and for building in the flexibility required to better integrate cell cycle progression with development. In this review we focus on cyclin B metabolism in mouse oocytes and embryos and illustrate how the cell cycle-powered clock (in fact cyclin B-powered clock) controls oocyte maturation and early embryo development, thereby providing important insight into human reproduction and potential causes of Down syndrome. %G English %L inserm-00684765 %U https://inserm.hal.science/inserm-00684765 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ IFR140 %~ IGDR %~ IGDR-CC %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA