This prospective observational cohort study was performed in the medical intensive care unit at the University Hospital of Caen, France, between November 2006 and October 2007. During the 12-month study period, 657 patients were admitted to the ICU. All older persons 75 years and over (n = 125) consecutively admitted to the ICU were assessed for eligibility. Surgical patients (n = 8) or patients who were obviously moribund or comatose after cardiac arrest (n= 17) were excluded from the analysis. All patients included were followed for 3 months or until death.

As a further note, during the study period 70 older patients (>75 years) requiring medical care but considered as too ill to benefit from intensive care, were withheld from the ICU.

The study protocol was submitted to the local independent ethics committee. The ethical board deemed that approval was not necessary, given the observational nature of this prospective study. Thus, in accordance with French legislation at the time of the study, no informed consent was obtained from the patients.

The following data were collected at the time of ICU admission for each patient: gender, age, marital status, location of usual residence, body mass index, underlying disease according to the Charlson index 9 , physical dependence and cognitive status one month prior to admission, assessed by the Katz index of Activity of Daily Living (ADL) 10 and a cognitive score based on the individual components of the Lawton index of Daily Living (IADL) 11 , date of admission to the emergency department or acute care hospital wards, number of organ failures according to the Sequential Organ Failure Assessment (SOFA) and the SOFA score 12 , severity of illness according to the Simplified Acute Physiologic Score II (SAPS II) 13 , and the Acute Physiology and Chronic Health Evaluation (APACHE II) 14 , need for ventilation or renal dialysis, and reasons for ICU admission.

During their ICU stay, the SOFA score, the number of organ failures, shock and need for ventilation or renal dialysis were sequentially reassessed at Day 3 and Day 7. The duration of mechanical ventilation, the ICU and hospital length of stay, decision to activate care withdrawal and the discharge destination, were also recorded. In addition, the ICU, hospital and 3-month mortalities were recorded. Moreover, all survivors were assessed by telephone interview for physical dependence and cognitive status and for the subjective perception of social and personal effects of ICU stay using the Nottingham Health Profile (NHP) score 15 , at 3 months following ICU admission.

The Charlson comorbidity index is based on the assignment of comorbidities observed in patients to one of several categories. A weighted score is assigned to each comorbidity, based on the relative risk of 1-year mortality. The sum of the index score is an indicator of disease burden and a predictor of death 9 . According to the modified version of the Charlson comorbidity index (applicable to the tenth revision of the International Classification of Diseases), 3 levels of comorbidity are defined: low (score = 0 or 1), medium (score = 2 to 4), and high (score = 5 or over) 16 17 18 .

The Katz index of Activity of Daily Living (ADL) 10 assesses the ability of patients to perform the daily activities of bathing, dressing, toileting, transferring, continence and feeding. This index correlates with physical dependence. In this study, patient dependence was described in one of 2 manners for each function: independent (1 point), and dependent (0 points). The worst ADL score obtained was 0 (complete dependence) and the best was 6 (complete independence).

The cognitive score includes the individual components of the Lawton index of Daily Living: ability to handle finances, responsibility for own medications, ability to use the telephone and mode of transportation. This score correlates with impairment of cognitive functions independent of age, sex and education 11 . For each function, patient dependence is described in 2 degrees: not dependent (0 point), and dependent (1 point). The worst score obtained in this study was 4 (complete dependence) and the best 0 (complete independence).

The Nottingham Health Profile (NHP), used in its validated French version 15 , assesses subjective health status by investigating the patient's subjective perception of social and personal effects of illness. It computes 38 statements divided into 6 categories: energy (3 questions), pain (8 questions), emotional reaction (9 questions), sleep (5 questions), social isolation (5 questions) and physical mobility (8 questions). In our study, the patients answered each question with "yes" (if there was a handicap, computed as 1) or "no" (if there was no handicap, computed as 0) about his/her situation at the time of the phone interview. Each "yes" was weighed according to its importance in the category and scored between 0 (maximum quality) and 100 (no quality). In each category, the worst score obtained was 100 and the best 0. The aggregate sum varied between 600 (maximum handicap) and 0 (no handicap). When a patient could not answer, the NPH score was not evaluated.

One hundred patients (65 male and 35 female) fulfilled the inclusion criteria for analysis. At 3 months, 61 patients (61%) had died (Figure 1). Baseline characteristics of admitted patients are shown in Table 1. The sex ratio (M/F) was 2/1. The mean age was 79.3 ± 3.4 years. Sixty-one patients were under 80 years old, 34 ranged from 80 to 85 years, and 5 were over 85. All patients but 9 lived at home, 58% of whom had been living with a partner before admission. The mean BMI was 27.3 ± 5.8, but 30 patients (30%) were obese (BMI >30). The median Charlson index was 6 [IQR, 4 to 7] and the mean physical dependence and cognitive scores were 5.4 ± 1.1 and 1.2 ± 1.4, respectively, corresponding to a population with a high level of comorbidities but low physical and cognitive dependence. According to the ADL index and cognitive score, respectively, 57% and 40% of the patients were completely independent (ADL index = 6, cognitive score = 0) and only 1% and 7% were completely dependent (ADL index = 0, cognitive score = 4). On ICU admission, the median SAPS II score and APACHE II score was 53 [IQR, 39 to 68] and 24 [IQR, 18 to 30], respectively. The main reasons for admission were respiratory disease (48%), cardiac disease (20%) and neurologic disease (12%). The median SOFA score was 7 [IQR, 5 to 7], and 24% of the patients satisfied multi-organ failure criteria (≥3 organ failures). With the exception of 12 patients, all required ventilator support; non invasive ventilation (NIV) in 25 patients (25%), and invasive mechanical ventilation in 63 patients (63%), 6 of whom received invasive mechanical ventilation after NIV failure. Forty-one patients (41%) were in shock and 12 patients (12%) needed additional renal support.

At 3 months 61 patients (61%) had died: 42 during their ICU stay, 13 after ICU discharge, and 6 after hospital discharge. Therefore, the majority of non survivors died during the ICU stay, half of them in the first week.

Thirty-six patients were subject to treatment limitation decisions. Thirty two died. However the length of their ICU stay did not differ from other patients (26 +/- 30 vs 30+/- 26 days; p = 0.15)

Risk factors associated with mortality in univariate analysis are shown in Tables 2 and 3. At ICU admission the Charlson index, the modified IADL index, the number of organ failures and the SOFA score were associated with mortality; however, the ADL index was not. During the ICU stay the number of organ failures, the SOFA score, the need for mechanical ventilation or extra-renal support, sequentially assessed, were significantly associated with mortality. Interestingly, all patients (n = 22) needing extra-renal support after Day 3 died. In addition, the decision to activate care withdrawal, the length of the hospital stay and hospital re-admission were also associated with 3-month mortality.

In multivariate analysis only the Charlson index [Adjusted Odds Ratio, 1.6; 95% CI, 1.2-2.2; p < 0.0025] and the number of organ failures [Adjusted Odds Ratio, 2.5; 95% CI, 1.15-5.2; p < 0.02] at ICU admission were independently associated with short-term mortality.

Forty-five patients (45%) were discharged from hospital to domicile (n = 32), families (n = 2) or an institution (n = 11). At the 3-month follow-up, 10 patients were re-hospitalized: 3 patients had been admitted to the ICU and 6 had died. One patient was lost to follow-up. Therefore, at 3 months 38 patients (35%) were still alive.

Compared with pre-admission, the physical dependence and the cognitive status of survivors had changed very little at 3 months. The pre-admission ADL index compared to the 3-month ADL index (n = 36) was 5.5 ± 0.9 vs 4.3 ± 1.6 (p = 0.04), and the pre-admission cognitive score compared to the 3-month cognitive score (n = 36) was 1.1 ± 1.3 vs 2.9 ± 1.40 (p = 0.62). The assessment of subjective health status by the Nottingham Health Profile (NHP) score was obtained directly in 26 survivors (68%) at 3 months. Twelve patients with difficulties with language (n = 7), memory (n = 3) or hearing (n = 2) were unable to answer at the time of the phone interview at 3 months. However, these difficulties had been present in 4 of them before ICU admission. The mean NHP score was 213.1 ± 132.8 at 3 months. The social isolation score (26.2 ± 28.6) and the emotional reaction score (25.2 ± 26.9) were lower than other variables tested (sleep 37.7 ± 28.8, pain 38.9 ± 27.6, energy 42.5 ± 35 and physical mobility 42.7 ± 36.1).

Few studies have focused on outcomes in the oldest patient population (≥ 75 yrs) admitted into an ICU 2 3 20 21 22 23 24 25 . Except for 1 study 24 , all have included a mixed population: medical, unplanned surgical and planned surgical. In this report, we focus exclusively on critically ill older persons under medical care, the population associated with the highest mortality 3 . A series of 100 older persons (15% of our ICU population), consecutively admitted to the ICU, were included in the analysis. Among them, 39% were 80 years and older. This result was in accordance with previous reports focused on the oldest patients in the ICU, ≥ 70 yrs 6 26 , ≥ 75 yrs 25 , or ≥ 80 yrs 3 24 , but differed from the 9% recently reported 27 , suggesting a more restrictive admission policy in the latter. Despite a median Charlson index of 6 [IQR, 4 to 7] corresponding to a high comorbidity level, patients assessed by ADL and cognitive indices had a low physical and cognitive dependence level. In accordance with previous studies 6 26 27 , more than half of the patients were independent and approximately 90% had been living at home before ICU admission, suggesting a selected population with good functional status. This result supports a recent study 2 reporting that functional status was an independent factor associated with refusal of ICU admission.

The 3-month mortality rate of 61% reported in this study did not differ from those previously reported in the oldest patients admitted to an ICU 2 3 20 24 26 27 . In accordance with previous studies, the majority of non survivors died during the ICU stay and half of them within the first week. Whether earlier treatment limitation decisions may influence this result is unlikely since the length of the ICU stay did not differ between patients with or without treatment limitations (26 +/- 30 vs 30+/- 26 days; p = 0.15), suggesting that these decisions were made late in the ICU stay. However, consistent with previous reports 28 29 focused on all ICU populations regardless of age, a decision to forgo life-sustaining therapy was associated with death. Nevertheless, information about the frequency and time of decisions to limit treatment is rarely described. In our practice, decisions are made by consensus among all the ICU staff (including physicians, nurses and consultants as needed) in accordance with the French "Leonetti" law regarding patient rights related to end of life. With the exception of conscious patients without cognitive impairment, patients and families are not involved in the decision-making process. However, their consent to follow the staff's decision is sought. Futility and poor expected quality of life are the most frequent reasons for withholding or withdrawing life-support therapies. Among studies focused on critically ill older persons, only 1 study 2 reported the proportion of patients (70%) subject to treatment withholding or withdrawal decisions. This report contrasts with the 36% treatment limitation decisions in our cohort.

Consistent with previous studies 3 24 25 26 27 , severe comorbidities and initial severity of illness are independently associated with short-term mortality.

Although the Charlson index was predictive for death in a large cohort of geriatric patients (≥75 yrs) hospitalized in medical wards consequent to emergencies 16 , it has rarely been assessed as a predictor for death in critically ill older patients (≥ 75 yrs). However, regardless of age, previous reports identified the Charlson index as an independent factor associated with hospital mortality in a mixed population (ICU and intermediate ICU) 30 or after discharge from an intermediate-care unit 31 . This index was also reported as an important prognostic factor for long-term survival after ICU discharge in trauma patients 32 and a mixed population (medical and surgical) 33 34 .

In addition, the occurrence or persistence of multi-organ failure concurrent with the need for extra-renal support after Day 3 was also strongly associated with death. Few studies have addressed the clinical impact of dialysis in critically ill elderly patients. Nevertheless, this result is consistent with 2 recent studies which reported hemofiltration 5 and dialysis results 35 , respectively, as predictive factors for death in patients 70 years and older with abdominal pathologies and in mixed medical-surgical populations 80 years and older admitted to the ICU. In contrast, dialysis was not associated with mortality in older persons (≥ 70 yrs) hospitalized in the ICU for ≥ 30 days 6 . Differences in definitions of older persons, type of recruitment (medical, unplanned surgical and planned surgical) and variables studied may explain this difference.

With the aim of optimizing the balance between life-saving and non beneficial intensive care, we believe these data could help intensive care specialists decide whether or not continuation of intensive care is the treatment of choice.

Interestingly, in this setting the cognitive score but not the physical dependence index was associated with death. This result suggests that the ICU outcome in older persons could be more strongly influenced by impairment of cognitive functions than physical dependence. These findings are consistent with a previous study 36 reporting that the Instrumental Activity Daily Living index and moderate to severe cognitive impairment, assessed by the Short Portable Mental Status Questionnaire, is predictive of death. Our results also agree with other studies which failed to show an association between physical dependence, assessed by the ADL index, and death in the ICU's oldest patients (≥. 85 yrs) 20 and in older persons needing ventilatory support 26 . In contrast, the ADL index was reported as a predictor of poor long-term outcome in other studies 36 37 . Further research is needed to clarify the impact of physical dependence and cognitive function impairment on short-term mortality in an elderly population undergoing medical treatment in the ICU.

Regarding the ADL and cognitive indices, there is little change in physical dependence and cognitive status in survivors at a 3-month follow-up. Only a transient decrease in physical status was observed, in accordance with previous studies 8 22 . In addition, subjective health status assessed by the NPH index was consistent with previous studies 6 38 39 using the same generic health indicator to assess quality of life in intensive care survivors. According to these reports, the psychosocial aspects of life (isolation and emotional reaction categories) were better than those of all other variables tested, in comparison with the results of the NPH index in the French general population of mixed age without hospitalization 15 . This result is also consistent with the accumulated body of literature 4 on the outcomes of older survivors of ICU stays, regardless of the choice and quality of tools used to assess quality of life. Nevertheless, these consistent results should be interpreted cautiously because of the small number of studies that specifically address this topic, the lack of a uniform approach to quality of life assessment and difficulties in follow-up after ICU discharge that make comparisons between series of patients challenging. In addition, the oldest patients could have a more positive perception of their quality of life than younger patients due to more acceptance of their physical limitations 39 .

This study has some limitations. The mono-centric design of the study, the relatively small sample size, the absence of assessment of subjective health status of patients before ICU admission, as well as the fact that during the period of study 70 older persons (≥ 75 yrs) requiring medical care were withheld from the ICU, may limit the interpretation and relevance of our data. Addressing the latter, the proportion of older persons who were not admitted to the ICU is consistent with a recent report 2 , and in our clinical practice triage decisions regarding admission to the ICU require the opinion of 2 senior practitioners and are guided by the recommendations of the Society of Critical Care Medicine 40 . We believe that this report contributes useful information about clinical outcomes, predictors of death and long-term quality of life in a selected older population requiring intensive care. Firstly, our study focuses on a population at high risk of ICU death (42% in our cohort vs 29% in patients 65 to 74 years old and 21% in patients 64 years old and younger during the same period, data not shown). Moreover, the study includes a high proportion (39%) of older persons 80 years and older. Finally, we used the most commonly employed scoring systems (specifically the Charlson index and the ADL index) available for geriatric populations.