%0 Journal Article %T Three kidneys, two diseases, one antibody? %+ Service de néphrologie [Rennes] %+ Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] %+ Service de néphrologie et d'hémodialyse %+ Institut de Génétique et Développement de Rennes (IGDR) %A Lorcy, Nolwenn %A Rioux-Leclercq, Nathalie %A Lombard, Marie-Laure %A Le Pogamp, Patrick %A Vigneau, Cécile %< avec comité de lecture %@ 0931-0509 %J Nephrology Dialysis Transplantation %I Oxford University Press %V 26 %N 11 %P 3811-3 %8 2011-11 %D 2011 %R 10.1093/ndt/gfr436 %M 21813829 %K anti-factor H antibody %K complement alternative pathway %K membranoproliferative glomerulonephritis %K thombotic microangiopathies %Z Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Anti-factor H antibody has been recently described as responsible for thrombotic microangiopathies (TMA) as well as membranoproliferative glomerulonephritis (MPGN). We report here, for the first time, the case of a woman with an anti-factor H antibody, who developed MPGN on native kidney, rapid recurrence on first graft, and TMA on second graft despite immunosuppressive therapy and plasma exchanges. This case supports the hypothesis that MPGN and TMA are closely linked by common pathogenic mechanisms and the need for complete exploration of complement pathway including factor H activity and autoantibody in front of any MPGN. %G English %L inserm-00618447 %U https://inserm.hal.science/inserm-00618447 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ HL %~ IGDR %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA