%0 Journal Article %T Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis. %+ Molécules Thérapeutiques in silico (MTI) %+ Compartimentation et dynamique cellulaires (CDC) %+ Institut Mondor de Recherche Biomédicale (IMRB) %+ CIC - Biotherapie - CHU Henri Mondor %+ Département d'Oncologie Radiothérapie %A Letouzé, Eric %A Allory, Yves %A Bollet, Marc, A. %A Radvanyi, François %A Guyon, Frédéric %Z This work was supported by the Centre National de la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale, the Institut Curie, the Institut National Contre le Cancer, the Ligue Nationale Contre le Cancer (EL, FR, accredited team), the Cancéropôle Ile de France and the Groupement d'Entreprises Françaises dans la Lutte contre le Cancer. Eric Letouzé was supported by a fellowship from the French Ministry of Education and Research and the Association pour la Recherche sur le Cancer. %< avec comité de lecture %@ 1465-6906 %J Genome Biology %I BioMed Central %V 11 %N 7 %P R76 %8 2010 %D 2010 %R 10.1186/gb-2010-11-7-r76 %M 20649963 %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X We present a computational method, TuMult, for reconstructing the sequence of copy number changes driving carcinogenesis, based on the analysis of several tumor samples from the same patient. We demonstrate the reliability of the method with simulated data, and describe applications to three different cancers, showing that TuMult is a valuable tool for the establishment of clonal relationships between tumor samples and the identification of chromosome aberrations occurring at crucial steps in cancer progression. %G English %2 https://inserm.hal.science/inserm-00539062/document %2 https://inserm.hal.science/inserm-00539062/file/gb-2010-11-7-r76.pdf %L inserm-00539062 %U https://inserm.hal.science/inserm-00539062 %~ INSERM %~ UNIV-PARIS7 %~ UPMC %~ CNRS %~ APHP %~ FNCLCC %~ CURIE %~ IMRB %~ UPEC %~ UMR144 %~ PSL %~ UPMC_POLE_4 %~ SORBONNE-UNIVERSITE %~ SU-SCIENCES %~ UNIV-PARIS %~ INSTITUT-CURIE-PSL %~ SU-TI %~ ALLIANCE-SU %~ TEST3-HALCNRS