In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles NeuroImage Year : 2008

In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.

Abstract

This study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents toward gliomas.
Fichier principal
Vignette du fichier
VersionAuteur.pdf (444.47 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00536177 , version 1 (22-06-2011)

Identifiers

  • HAL Id : inserm-00536177 , version 1
  • PUBMED : 18441552

Cite

Samuel Valable, Emmanuel L Barbier, Myriam Bernaudin, Simon Roussel, Christoph Segebarth, et al.. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.. NeuroImage, 2008, 40 (2), pp.973-83. ⟨inserm-00536177⟩
317 View
491 Download

Altmetric

Share

Gmail Facebook X LinkedIn More