%0 Journal Article %T Blockade of the kinin B1 receptor ameloriates glomerulonephritis. %+ Institut de médecine moléculaire de Rangueil (I2MR) %+ Service de Pédiatrie - Néphrologie, Médecine interne, Hypertension %+ Department of Medicine %+ Department of Medicine %+ Department of Pathology and Medical Biology %+ Department of Biophysics %A Klein, Julie %A Gonzalez, Julien %A Decramer, Stéphane %A Bandin, Flavio %A Neau, Eric %A Salant, David, J. %A Heeringa, Peter %A Pesquero, Joao-Bosco %A Schanstra, Joost-Peter %A Bascands, Jean-Loup %< avec comité de lecture %@ 1046-6673 %J Journal of the American Society of Nephrology %I American Society of Nephrology %V 21 %N 7 %P 1157-64 %8 2010-07 %D 2010 %R 10.1681/ASN.2009090887 %M 20448019Journal articles %X Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. Delayed B1R blockade reduces renal inflammation in a model of unilateral ureteral obstruction, but whether B1R modulates the pathophysiology of glomerulonephritides is unknown. Here, we observed an association of B1R protein expression and inflammation, in both glomeruli and the renal interstitium, in biopsies of patients with glomerulonephritides, Henoch-Schönlein purpura nephropathy, and ANCA-associated vasculitis. In the nephrotoxic serum-induced glomerulonephritis model, we observed upregulation of the B1R receptor; treatment with a B1R antagonist beginning 2 weeks after the onset of disease reduced both glomerular and tubular lesions and improved renal function. B1R blockade reduced renal chemokine expression and macrophage accumulation. Collectively, our data demonstrate that blockade of the kinin B1R has significant potential for the treatment of glomerulonephritis. %G English %L inserm-00506236 %U https://inserm.hal.science/inserm-00506236 %~ INSERM %~ UNIV-TLSE3 %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP