Sertoli cell Dicer is essential for spermatogenesis in mice. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Developmental Biology Year : 2009

Sertoli cell Dicer is essential for spermatogenesis in mice.

Olivier Schaad
  • Function : Author
Wei Yan
  • Function : Author
  • PersonId : 762946
  • IdRef : 191622281


Spermatogenesis requires intact, fully competent Sertoli cells. Here, we investigate the functions of Dicer, an RNaseIII endonuclease required for microRNA and small interfering RNA biogenesis, in mouse Sertoli cell function. We show that selective ablation of Dicer in Sertoli cells leads to infertility due to complete absence of spermatozoa and progressive testicular degeneration. The first morphological alterations appear already at postnatal day 5 and correlate with a severe impairment of the prepubertal spermatogenic wave, due to defective Sertoli cell maturation and incapacity to properly support meiosis and spermiogenesis. Importantly, we find several key genes known to be essential for Sertoli cell function to be significantly down-regulated in neonatal testes lacking Dicer in Sertoli cells. Overall, our results reveal novel essential roles played by the Dicer-dependent pathway in mammalian reproductive function, and thus pave the way for new insights into human infertility.
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inserm-00504465 , version 1 (20-07-2010)



Marilena D. Papaioannou, Jean-Luc Pitetti, Seungil Ro, Chanjae Park, Florence Aubry, et al.. Sertoli cell Dicer is essential for spermatogenesis in mice.. Developmental Biology, 2009, 326 (1), pp.250-9. ⟨10.1016/j.ydbio.2008.11.011⟩. ⟨inserm-00504465⟩
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