<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-00499643</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T08:16:14+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.</title>
            <title xml:lang="en" type="sub">5-HT Transporter Inhibition Prevents PH</title>
            <author role="crp">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Guignabert</surname>
              </persName>
              <email type="md5">19dbdb5965ab68c38865a122a5dcf169</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">christophe-guignabert</idno>
              <idno type="idhal" notation="numeric">184750</idno>
              <idno type="halauthorid" notation="string">10960-184750</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-3873-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8545-4452</idno>
              <idno type="IDREF">https://www.idref.fr/095316213</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-3873-2013</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=11rsPwQAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/214257028</idno>
              <idno type="ISNI">http://isni.org/isni/000000013925142X</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernadette</forename>
                <surname>Raffestin</surname>
              </persName>
              <idno type="halauthorid">476367-0</idno>
              <affiliation ref="#struct-121015"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rima</forename>
                <surname>Benferhat</surname>
              </persName>
              <idno type="halauthorid">171798-0</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">William</forename>
                <surname>Raoul</surname>
              </persName>
              <email type="md5">cb6d8864ef4aa9290b1929f1407a1470</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">william-raoul</idno>
              <idno type="idhal" notation="numeric">5964</idno>
              <idno type="halauthorid" notation="string">3911-5964</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5040-3372</idno>
              <idno type="IDREF">https://www.idref.fr/097642215</idno>
              <idno type="GOOGLE SCHOLAR">OlMoau8AAAAJ</idno>
              <affiliation ref="#struct-8529"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patricia</forename>
                <surname>Zadigue</surname>
              </persName>
              <idno type="halauthorid">476359-0</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Rideau</surname>
              </persName>
              <idno type="halauthorid">386982-0</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Hamon</surname>
              </persName>
              <idno type="halauthorid">138998-0</idno>
              <affiliation ref="#struct-26565"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Serge</forename>
                <surname>Adnot</surname>
              </persName>
              <idno type="halauthorid">193243-0</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Saadia</forename>
                <surname>Eddahibi</surname>
              </persName>
              <idno type="halauthorid">193244-0</idno>
              <affiliation ref="#struct-8529"/>
              <affiliation ref="#struct-121014"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Christophe</forename>
                <surname>Guignabert</surname>
              </persName>
              <email type="md5">19dbdb5965ab68c38865a122a5dcf169</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>This research was supported by grants from INSERM, the Ministère de la Recherche, the Délégation à la Recherche Clinique de l'AP-HP, and the Fondation de France. We are grateful to the pharmaceutical companies Janssen, Lilly, Lundbeck, Roche, and SmithKline Beecham for generously donating the drugs used in this study.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2010-07-11 16:05:23</date>
              <date type="whenModified">2026-04-02 17:12:03</date>
              <date type="whenReleased">2010-07-12 17:23:37</date>
              <date type="whenProduced">2005-05-31</date>
              <date type="whenEndEmbargoed">2010-07-11</date>
              <ref type="file" target="https://inserm.hal.science/inserm-00499643v1/document">
                <date notBefore="2010-07-11"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://inserm.hal.science/inserm-00499643v1/file/Guignabert_et_al_Circulation.pdf" id="file-499643-703737">
                <date notBefore="2010-07-11"/>
              </ref>
              <ref type="externalLink" target="http://www.hal.inserm.fr/inserm-00499643/file/Guignabert_et_al_Circulation.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="132762">
                <persName>
                  <forename>Christophe</forename>
                  <surname>Guignabert</surname>
                </persName>
                <email type="md5">19dbdb5965ab68c38865a122a5dcf169</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00499643</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-00499643</idno>
            <idno type="halBibtex">guignabert:inserm-00499643</idno>
            <idno type="halRefHtml">&lt;i&gt;Circulation&lt;/i&gt;, 2005, 111 (21), pp.2812-9. &lt;a target="_blank" href="https://dx.doi.org/10.1161/CIRCULATIONAHA.104.524926"&gt;&amp;#x27E8;10.1161/CIRCULATIONAHA.104.524926&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Circulation, 2005, 111 (21), pp.2812-9. &amp;#x27E8;10.1161/CIRCULATIONAHA.104.524926&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-499643-703737"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CARDIO" corresp="INSERM">Cardiovasculaire</idno>
            <idno type="stamp" n="UPEC" corresp="CV_UPEC">Université Paris-Est Créteil Val-de-Marne</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST-UPEC-ODD" corresp="UPEC">TEST UPEC ODD</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">9 pages</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.</title>
                <title xml:lang="en" type="sub">5-HT Transporter Inhibition Prevents PH</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Guignabert</surname>
                  </persName>
                  <email type="md5">19dbdb5965ab68c38865a122a5dcf169</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">christophe-guignabert</idno>
                  <idno type="idhal" notation="numeric">184750</idno>
                  <idno type="halauthorid" notation="string">10960-184750</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-3873-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8545-4452</idno>
                  <idno type="IDREF">https://www.idref.fr/095316213</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-3873-2013</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=11rsPwQAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/214257028</idno>
                  <idno type="ISNI">http://isni.org/isni/000000013925142X</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernadette</forename>
                    <surname>Raffestin</surname>
                  </persName>
                  <idno type="halauthorid">476367-0</idno>
                  <affiliation ref="#struct-121015"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rima</forename>
                    <surname>Benferhat</surname>
                  </persName>
                  <idno type="halauthorid">171798-0</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">William</forename>
                    <surname>Raoul</surname>
                  </persName>
                  <email type="md5">cb6d8864ef4aa9290b1929f1407a1470</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">william-raoul</idno>
                  <idno type="idhal" notation="numeric">5964</idno>
                  <idno type="halauthorid" notation="string">3911-5964</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5040-3372</idno>
                  <idno type="IDREF">https://www.idref.fr/097642215</idno>
                  <idno type="GOOGLE SCHOLAR">OlMoau8AAAAJ</idno>
                  <affiliation ref="#struct-8529"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patricia</forename>
                    <surname>Zadigue</surname>
                  </persName>
                  <idno type="halauthorid">476359-0</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Rideau</surname>
                  </persName>
                  <idno type="halauthorid">386982-0</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Hamon</surname>
                  </persName>
                  <idno type="halauthorid">138998-0</idno>
                  <affiliation ref="#struct-26565"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Serge</forename>
                    <surname>Adnot</surname>
                  </persName>
                  <idno type="halauthorid">193243-0</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Saadia</forename>
                    <surname>Eddahibi</surname>
                  </persName>
                  <idno type="halauthorid">193244-0</idno>
                  <affiliation ref="#struct-8529"/>
                  <affiliation ref="#struct-121014"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11717</idno>
                <idno type="issn">0009-7322</idno>
                <idno type="eissn">1524-4539</idno>
                <title level="j">Circulation</title>
                <imprint>
                  <publisher>American Heart Association</publisher>
                  <biblScope unit="volume">111</biblScope>
                  <biblScope unit="issue">21</biblScope>
                  <biblScope unit="pp">2812-9</biblScope>
                  <date type="datePub">2005-05-31</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1161/CIRCULATIONAHA.104.524926</idno>
              <idno type="pubmed">15927991</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">pulmonary heart disease</term>
                <term xml:lang="en">remodeling</term>
                <term xml:lang="en">muscle</term>
                <term xml:lang="en">smooth</term>
              </keywords>
              <classCode scheme="mesh">Cell Proliferation</classCode>
              <classCode scheme="mesh">Receptor, Serotonin, 5-HT2A</classCode>
              <classCode scheme="mesh">Serotonin Plasma Membrane Transport Proteins</classCode>
              <classCode scheme="mesh">Serotonin Uptake Inhibitors</classCode>
              <classCode scheme="mesh">Up-Regulation</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Fluoxetine</classCode>
              <classCode scheme="mesh">Hypertension, Pulmonary</classCode>
              <classCode scheme="mesh">Lung</classCode>
              <classCode scheme="mesh">Monocrotaline</classCode>
              <classCode scheme="mesh">Muscle, Smooth, Vascular</classCode>
              <classCode scheme="mesh">Rats</classCode>
              <classCode scheme="mesh">Receptor, Serotonin, 5-HT1B</classCode>
              <classCode scheme="mesh">Receptor, Serotonin, 5-HT1D</classCode>
              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.psr">Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.csc">Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.phy">Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]</classCode>
              <classCode scheme="halDomain" n="sdv.ba">Life Sciences [q-bio]/Animal biology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halDomain" n="chim.ther">Chemical Sciences/Medicinal Chemistry</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs). Given the postulated causal relation between 5-HTT overexpression and PH, we herein investigated whether the highly selective 5-HTT inhibitor fluoxetine prevented and/or reversed PH induced by monocrotaline (MCT) in rats. Selective 5-HT(1B/1D), 5-HT(2A), and 5-HT(2B) receptor antagonists were used for comparative testing. METHODS AND RESULTS: MCT injection (60 mg/kg SC) was followed by an early peak in lung 5-HTT expression on day 1, which preceded the onset of PH. Established PH on day 15 was associated with a sustained 5-HTT increase. Continued fluoxetine treatment completely prevented PA-SMC proliferation and PH development and also suppressed the late 5-HTT increase, without affecting the early peak. The 5-HT receptor antagonists did not affect PH. Fluoxetine (10 mg . kg(-1) . d(-1) PO) started 3 weeks after MCT injection completely reversed established PH, normalizing PA pressure and structure. MCT-induced PH was also associated with increased expression of various cytokines, but only interleukin-1beta and monocyte chemotactic protein-1 increased at the early phase and stimulated 5-HTT expression by cultured PA-SMCs. CONCLUSIONS: Upregulation of lung 5-HTT induced by MCT appears necessary to initiate the development of pulmonary vascular remodeling, whereas a sustained increase in 5-HTT expression may underlie both the progression and the maintenance of MCT-induced PH. Complete reversal of established PH by fluoxetine provides a rationale for new therapeutic strategies in human PH.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-8529" status="OLD">
          <orgName>Physiopathologie et Thérapeutiques Respiratoires</orgName>
          <desc>
            <address>
              <addrLine>51 Avenue du Maréchal de Lattre de Tassigny 94010 Créteil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-2731" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation name="IFR10" active="#struct-303623" type="direct"/>
            <relation active="#struct-420786" type="indirect"/>
            <relation name="U492" active="#struct-303623" type="direct"/>
            <relation active="#struct-366262" type="direct"/>
            <relation active="#struct-103061" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-121014" status="INCOMING">
          <orgName>Service de chirurgie thoracique et d'anatomopathologie</orgName>
          <desc>
            <address>
              <addrLine>Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-311503" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-121015" status="INCOMING">
          <orgName>Département de physiologie</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300151" type="direct"/>
            <relation active="#struct-301664" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-26565" status="OLD">
          <orgName>Neuropsychopharmacologie moléculaire, cellulaire et fonctionnelle</orgName>
          <desc>
            <address>
              <addrLine>CHU Pitié Salpétrière 91 Boulevard de l'Hôpital 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-93591" type="direct"/>
            <relation name="U288" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2731" status="OLD">
          <orgName>Institut Mondor de médecine moléculaire</orgName>
          <orgName type="acronym">Im3</orgName>
          <date type="end">2008-12-31</date>
          <desc>
            <address>
              <addrLine>Faculte de Medecine 8, Rue du General Sarrail 94010 CRETEIL CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.im3.inserm.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="IFR10" active="#struct-303623" type="direct"/>
            <relation active="#struct-420786" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-420786" status="VALID">
          <idno type="IdRef">028021037</idno>
          <idno type="ISNI">0000000121497878</idno>
          <idno type="ROR">https://ror.org/05ggc9x40</idno>
          <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName>
          <orgName type="acronym">UPEC UP12</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-pec.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-366262" status="VALID">
          <idno type="ROR">https://ror.org/04m61mj84</idno>
          <orgName>CHU Henri Mondor [Créteil]</orgName>
          <desc>
            <address>
              <addrLine>51, avenue du Maréchal de Lattre de Tassigny 94000 Créteil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-103061" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-103061" status="VALID">
          <orgName>Groupe Henri Mondor-Albert Chenevier</orgName>
          <desc>
            <address>
              <addrLine>Créteil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-311503" status="INCOMING">
          <orgName>Hôpital Hôtel Dieu</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300151" status="VALID">
          <idno type="ROR">https://ror.org/03j6rvb05</idno>
          <orgName>Hôpital Ambroise Paré [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>9, avenue Charles de Gaulle92104 Boulogne-Billancourt cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-93591" status="OLD">
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>