%0 Journal Article %T Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol. %+ Epilepsie et Ischemie Cerebrale %+ Neurobiologie et neuropharmacologie des épilepsies généralisées %A Chevassus-Au-Louis, Nicolas %A Ben-Ari, Yehezkel %A Vergnes, Marguerite %< avec comité de lecture %@ 0006-8993 %J Brain Research %I Elsevier %V 812 %N 1-2 %P 252-5 %8 1998-11-23 %D 1998 %M 9813354 %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X In humans, cortical malformations are highly epileptogenic. In rats, prenatal treatment with methylazoxymethanol (MAM) cause a diffuse cortical malformation that is yet not associated with seizures. We performed rapid hippocampal kindling in MAM and control rats. We show that MAM rats present (i) a lower initial afterdischarge threshold; (ii) a more rapid progression to generalized seizures. We conclude that MAM rats may serve as models for human epileptogenic cortical malformations. %G English %2 https://inserm.hal.science/inserm-00487297/document %2 https://inserm.hal.science/inserm-00487297/file/Chevassus_Ben-Ari_Vergnes_BrRes_1998.pdf %L inserm-00487297 %U https://inserm.hal.science/inserm-00487297 %~ INSERM %~ UNIV-PARIS5 %~ UNIV-PARIS