Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Neuron Year : 2002

Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.

Abstract

The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that are mediated solely by kainate receptors (EPSC(kainate)) or by both AMPA and kainate receptors (EPSC(AMPA/kainate)). EPSC(kainate) and EPSC(AMPA/kainate) are selectively enriched in CA1 interneurons and mossy fibers synapses of CA3 pyramidal neurons, respectively. In CA1 interneurons, the decay time constant of EPSC(kainate) (circa 10 ms) is comparable to values obtained in heterologous expression systems. In both hippocampal neurons, the quantal release of glutamate generates kainate receptor-mediated EPSCs that provide as much as half of the total glutamatergic current. Kainate receptors are, therefore, key players of the ongoing glutamatergic transmission in the hippocampus.
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Dates and versions

inserm-00484870 , version 1 (19-05-2010)

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  • HAL Id : inserm-00484870 , version 1
  • PUBMED : 12123615

Cite

Rosa Cossart, Jérôme Epsztein, Roman Tyzio, Hélène Becq, June C. Hirsch, et al.. Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.. Neuron, 2002, 35 (1), pp.147-59. ⟨inserm-00484870⟩

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