%0 Journal Article %T Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia. %+ Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249) %A Epsztein, Jérôme %A Ben-Ari, Yehezkel %A Represa, Alfonso %A Crépel, Valérie %< avec comité de lecture %@ 1073-8584 %J Neuroscientist %I SAGE Publications %V 14 %N 1 %P 78-90 %8 2008-02 %D 2008 %R 10.1177/1073858407301681 %M 17914086 %K Epileptogenesis %K Poststroke seizure %K Ischemia %K Stroke %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis. %G English %2 https://inserm.hal.science/inserm-00483497/document %2 https://inserm.hal.science/inserm-00483497/file/6-Epsztein_2008.pdf %L inserm-00483497 %U https://inserm.hal.science/inserm-00483497 %~ INSERM %~ UNIV-AMU %~ INMED