%0 Journal Article %T Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation. %+ Institut de Génétique et Développement de Rennes (IGDR) %+ Université européenne de Bretagne - European University of Brittany (UEB) %A Le Tonquèze, Olivier %A Gschloessl, Bernhard %A Namanda-Vanderbeken, Allen %A Legagneux, Vincent %A Paillard, Luc %A Audic, Yann %< avec comité de lecture %@ 0006-291X %J Biochemical and Biophysical Research Communications %I Elsevier %V 394 %N 4 %P 884-9 %8 2010-04-16 %D 2010 %R 10.1016/j.bbrc.2010.03.020 %M 20227387 %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression. %G English %L inserm-00466153 %U https://inserm.hal.science/inserm-00466153 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ IGDR %~ IGDR-EGD %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA