%0 Journal Article %T [Non-fatal disseminated mucormycosis in a solid organ transplant] %+ Unité de pneumologie %+ Unité de Réanimation médicale %+ Unité d'Oto-rhinolaryngologie %+ Département d'anatomie et cythologie pathologique %+ Clinique de réanimation médicale %+ Unité de Parasitologie-mycologie %+ Laboratoire de parasitologie et mycologie %+ Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823) %A Minet, Clémence %A Bonadona, Agnès %A Tabah, Alexis %A Karkas, Alexandre, A. %A Mescam, L. %A Schwebel, Carole %A Hamidfar, Rebecca %A Pison, Christophe, M. %A Saint-Raymond, Christel %A Faure, Odile %A Salameire, Dimitri %A Timsit, Jean-François %< avec comité de lecture %@ 0761-8425 %J Revue des Maladies Respiratoires %I Elsevier Masson %V 26 %N 9 %P 998-1002 %8 2009-11 %D 2009 %M 19953048 %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X BACKGROUND: Mucormycosis is a rare fungal infection occurring most frequently in immunocompromised patients. The pathogens are filamentous fungi, order of Mucorales. Disseminated mucormycosis is a severe, life treating disease. Early diagnosis is a major determinant for prognosis, however, it remains difficult. The management consists in an early antifungal therapy using lipid formulation of amphotericin B associated with an extensive surgical debridement. Despite this therapeutic of choice, the mortality of disseminated mucormycosis remains high. OBSERVATION: We report the case of disseminated mucormycosis in a 25 years old woman 9 months after a pulmonary transplantation. The clinical presentation included pulmonary and thyroid localization and the pathogen was Absidia corymbifera. The patient survived thanks to a large surgical debridement, and an early antifungal bitherapy by lipid formulation of amphotericin B and posaconazole. CONCLUSION: The re-emergence and the high mortality of mucormycosis in solid organ transplant receiver show the necessity to find new therapeutic approaches. Posaconazole associated with liposomal amphotericin B could be an interesting option to treat disseminated mucormycosis and improve their outcome. %G French %L inserm-00453180 %U https://inserm.hal.science/inserm-00453180 %~ INSERM %~ UGA %~ UNIV-GRENOBLE1 %~ U823 %~ SANTE_PUB_INSERM