Calpain 2 is required for sister chromatid cohesion. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Chromosoma Year : 2010

Calpain 2 is required for sister chromatid cohesion.

Abstract

Calpains form a family of Ca(2+)-dependent cysteine proteases involved in diverse cellular processes. However, the specific functions of each calpain isoform remain unknown. Recent reports have shown that calpain 2 (Capn2) is essential for cell viability. We have recently shown that Capn2 is a nuclear protease associated with chromosomes during mitosis in mammalian embryonic cells. We now report that Capn2 depletion impairs mitosis and induces apoptosis in murine cells. Low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation. Thus, Capn2 may play a role in fundamental mitotic functions, such as the maintenance of sister chromatid cohesion.

Dates and versions

inserm-00452070 , version 1 (01-02-2010)

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Laura Magnaghi-Jaulin, Anne Marcilhac, Mireille Rossel, Christian Jaulin, Yves Benyamin, et al.. Calpain 2 is required for sister chromatid cohesion.. Chromosoma, 2010, 119 (3), pp.267-74. ⟨10.1007/s00412-010-0255-z⟩. ⟨inserm-00452070⟩
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