%0 Journal Article %T CT characteristics of resolving ground-glass opacities in a lung cancer screening programme. %+ Clinique Universitaire de Radiologie et Imagerie Médicale %+ Pôle d'imagerie %+ Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823) %+ Département d'anatomie Pathologique %+ Clinique Universitaire Pneumologique %A Felix, Laure %A Serra-Tosio, Géraldine %A Lantuejoul, Sylvie %A Timsit, Jean-François %A Moro-Sibilot, Denis %A Brambilla, Christian %A Ferretti, Gilbert, R. %< avec comité de lecture %@ 0720-048X %J European Journal of Radiology %I Elsevier %P epub ahead of print %8 2009-10-03 %D 2009 %R 10.1016/j.ejrad.2009.09.008 %M 19804950 %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X PURPOSE: This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer. MATERIAL AND METHODS: 280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n=83), head and neck cancer history (n=63), symptomatic (n=88) and asymptomatic (n=46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests. RESULTS: A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p=0.006), polygonal in shape (p=0.02), mixed (p=0.003) and larger (p<0.0001) than non-resolving localized GGOs. CONCLUSION: Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs. %G English %L inserm-00449329 %U https://inserm.hal.science/inserm-00449329 %~ INSERM %~ UGA %~ UNIV-GRENOBLE1 %~ U823 %~ SANTE_PUB_INSERM