<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-00442929</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T10:15:22+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="it">Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.</title>
            <title xml:lang="en" type="sub">Radioimmunotherapy with 125I-mAbs</title>
            <author role="aut">
              <persName>
                <forename type="first">Lore</forename>
                <surname>Santoro</surname>
              </persName>
              <idno type="idhal" notation="numeric">759364</idno>
              <idno type="halauthorid" notation="string">275100-759364</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8935-1450</idno>
              <affiliation ref="#struct-55685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Samir</forename>
                <surname>Boutaleb</surname>
              </persName>
              <idno type="halauthorid">434011-0</idno>
              <affiliation ref="#struct-55685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Véronique</forename>
                <surname>Garambois</surname>
              </persName>
              <idno type="halauthorid">170545-0</idno>
              <affiliation ref="#struct-55685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Bascoul-Mollevi</surname>
              </persName>
              <email type="md5">0c86c9137e8fa4923350f4cb3ceb51ad</email>
              <email type="domain">chu-montpellier.fr</email>
              <idno type="idhal" notation="string">caroline-mollevi</idno>
              <idno type="idhal" notation="numeric">751492</idno>
              <idno type="halauthorid" notation="string">206558-751492</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4827-3684</idno>
              <affiliation ref="#struct-300222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Boudousq</surname>
              </persName>
              <idno type="halauthorid">434012-0</idno>
              <affiliation ref="#struct-55685"/>
              <affiliation ref="#struct-106440"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Olivier</forename>
                <surname>Kotzki</surname>
              </persName>
              <idno type="halauthorid">338867-0</idno>
              <affiliation ref="#struct-55685"/>
              <affiliation ref="#struct-106440"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Monique</forename>
                <surname>Pèlegrin</surname>
              </persName>
              <idno type="halauthorid">321091-0</idno>
              <affiliation ref="#struct-55685"/>
              <affiliation ref="#struct-300222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Navarro-Teulon</surname>
              </persName>
              <idno type="halauthorid">210925-0</idno>
              <affiliation ref="#struct-55685"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">André</forename>
                <surname>Pèlegrin</surname>
              </persName>
              <email type="md5">cef2cab8c20d33e9745fa7c723931251</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">andre-pelegrin</idno>
              <idno type="idhal" notation="numeric">176279</idno>
              <idno type="halauthorid" notation="string">2764-176279</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-3167-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9254-2648</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-3167-2016</idno>
              <affiliation ref="#struct-55685"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Jean-Pierre</forename>
                <surname>Pouget</surname>
              </persName>
              <email type="md5">0e15942427048fd7f157526bc1333715</email>
              <email type="domain">valdorel.fnclcc.fr</email>
              <idno type="idhal" notation="string">jean-pierre-pouget</idno>
              <idno type="idhal" notation="numeric">180110</idno>
              <idno type="halauthorid" notation="string">17910-180110</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8551-2029</idno>
              <idno type="IDREF">https://www.idref.fr/131598449</idno>
              <affiliation ref="#struct-55685"/>
              <affiliation ref="#struct-300040"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Yves</forename>
                <surname>Le Ster</surname>
              </persName>
              <email type="md5">26a6def8078afcdd00d94ecde4e470ca</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>Electricité de France-Service de Radioprotection.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2010-11-19 14:33:55</date>
              <date type="whenModified">2026-05-18 10:14:10</date>
              <date type="whenReleased">2010-01-14 16:09:57</date>
              <date type="whenProduced">2009-12</date>
              <date type="whenEndEmbargoed">2010-11-19</date>
              <ref type="file" target="https://inserm.hal.science/inserm-00442929v1/document">
                <date notBefore="2010-11-19"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inserm.hal.science/inserm-00442929v1/file/inserm-00442929_edited.pdf" id="file-442929-333418">
                <date notBefore="2010-11-19"/>
              </ref>
              <ref type="file" subtype="author" n="0" target="https://inserm.hal.science/inserm-00442929v1/file/Revised_Pouget_JNM_august_2009.pdf" id="file-442929-333419">
                <date notBefore="2010-11-19"/>
              </ref>
              <ref type="externalLink" target="http://jnm.snmjournals.org/content/50/12/2033.full.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="117651">
                <persName>
                  <forename>Yves</forename>
                  <surname>Le Ster</surname>
                </persName>
                <email type="md5">26a6def8078afcdd00d94ecde4e470ca</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00442929</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-00442929</idno>
            <idno type="halBibtex">santoro:inserm-00442929</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Nuclear Medicine&lt;/i&gt;, 2009, 50 (12), pp.2033-41. &lt;a target="_blank" href="https://dx.doi.org/10.2967/jnumed.109.066993"&gt;&amp;#x27E8;10.2967/jnumed.109.066993&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Nuclear Medicine, 2009, 50 (12), pp.2033-41. &amp;#x27E8;10.2967/jnumed.109.066993&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-442929-333418"/><ref corresp="#file-442929-333419"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="IRSN">Institut de radioprotection et de sûreté nucléaire - IRSN</idno>
            <idno type="stamp" n="UNIV-MONTP1">Université Montpellier I</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="VALDAURELLE" corresp="FNCLCC">CRLC Val d'Aurelle - Paul Lamarque</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="IRCM" corresp="UNIV-MONTPELLIER">Institut de Recherche en Cancérologie de Montpellier</idno>
            <idno type="stamp" n="UM1-UM2" corresp="UNIV-MONTPELLIER">Université Montpellier 1 - Université Montpellier 2</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="ASNR">Autorité de Sûreté Nucléaire et de Radioprotection</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="it">Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.</title>
                <title xml:lang="en" type="sub">Radioimmunotherapy with 125I-mAbs</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Lore</forename>
                    <surname>Santoro</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">759364</idno>
                  <idno type="halauthorid" notation="string">275100-759364</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8935-1450</idno>
                  <affiliation ref="#struct-55685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Samir</forename>
                    <surname>Boutaleb</surname>
                  </persName>
                  <idno type="halauthorid">434011-0</idno>
                  <affiliation ref="#struct-55685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Véronique</forename>
                    <surname>Garambois</surname>
                  </persName>
                  <idno type="halauthorid">170545-0</idno>
                  <affiliation ref="#struct-55685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Bascoul-Mollevi</surname>
                  </persName>
                  <email type="md5">0c86c9137e8fa4923350f4cb3ceb51ad</email>
                  <email type="domain">chu-montpellier.fr</email>
                  <idno type="idhal" notation="string">caroline-mollevi</idno>
                  <idno type="idhal" notation="numeric">751492</idno>
                  <idno type="halauthorid" notation="string">206558-751492</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4827-3684</idno>
                  <affiliation ref="#struct-300222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Boudousq</surname>
                  </persName>
                  <idno type="halauthorid">434012-0</idno>
                  <affiliation ref="#struct-55685"/>
                  <affiliation ref="#struct-106440"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Olivier</forename>
                    <surname>Kotzki</surname>
                  </persName>
                  <idno type="halauthorid">338867-0</idno>
                  <affiliation ref="#struct-55685"/>
                  <affiliation ref="#struct-106440"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Monique</forename>
                    <surname>Pèlegrin</surname>
                  </persName>
                  <idno type="halauthorid">321091-0</idno>
                  <affiliation ref="#struct-55685"/>
                  <affiliation ref="#struct-300222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Navarro-Teulon</surname>
                  </persName>
                  <idno type="halauthorid">210925-0</idno>
                  <affiliation ref="#struct-55685"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">André</forename>
                    <surname>Pèlegrin</surname>
                  </persName>
                  <email type="md5">cef2cab8c20d33e9745fa7c723931251</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">andre-pelegrin</idno>
                  <idno type="idhal" notation="numeric">176279</idno>
                  <idno type="halauthorid" notation="string">2764-176279</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-3167-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9254-2648</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-3167-2016</idno>
                  <affiliation ref="#struct-55685"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Jean-Pierre</forename>
                    <surname>Pouget</surname>
                  </persName>
                  <email type="md5">0e15942427048fd7f157526bc1333715</email>
                  <email type="domain">valdorel.fnclcc.fr</email>
                  <idno type="idhal" notation="string">jean-pierre-pouget</idno>
                  <idno type="idhal" notation="numeric">180110</idno>
                  <idno type="halauthorid" notation="string">17910-180110</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8551-2029</idno>
                  <idno type="IDREF">https://www.idref.fr/131598449</idno>
                  <affiliation ref="#struct-55685"/>
                  <affiliation ref="#struct-300040"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21868</idno>
                <idno type="issn">0161-5505</idno>
                <idno type="eissn">1535-5667</idno>
                <title level="j">Journal of Nuclear Medicine</title>
                <imprint>
                  <publisher>Society of Nuclear Medicine</publisher>
                  <biblScope unit="volume">50</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">2033-41</biblScope>
                  <date type="datePub">2009-12</date>
                  <date type="dateEpub">2009-11-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.2967/jnumed.109.066993</idno>
              <idno type="pubmed">19910417</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">radioimmunotherapy</term>
                <term xml:lang="en">Auger electrons</term>
                <term xml:lang="en">solid tumors</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.ib.mn">Life Sciences [q-bio]/Bioengineering/Nuclear medicine</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>We have previously shown that, in vitro, monoclonal antibodies (mAbs) labeled with the Auger electron emitter (125)I are more cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the in vivo biologic efficiency of internalizing and noninternalizing (125)I-labeled mAbs for the treatment of small solid tumors. METHODS: Swiss nude mice bearing intraperitoneal tumor cell xenografts were injected with 37 MBq (370 MBq/mg) of internalizing (anti-HER1) (125)I-m225 or noninternalizing (anti-CEA) (125)I-35A7 mAbs at days 4 and 7 after tumor cell grafting. Nonspecific toxicity was assessed using the irrelevant (125)I-PX mAb, and untreated controls were injected with NaCl. Tumor growth was followed by bioluminescence imaging. Mice were sacrificed when the bioluminescence signal reached 4.5 x 10(7) photons/s. Biodistribution analysis was performed to determine the activity contained in healthy organs and tumor nodules, and total cumulative decays were calculated. These values were used to calculate the irradiation dose by the MIRD formalism. RESULTS: Median survival (MS) was 19 d in the NaCl-treated group. Similar values were obtained in mice treated with unlabeled PX (MS, 24 d) and 35A7 (MS, 24 d) or with (125)I-PX mAbs (MS, 17 d). Conversely, mice treated with unlabeled or labeled internalizing m225 mAb (MS, 76 and 77 d, respectively) and mice injected with (125)I-35A7 mAb (MS, 59 d) showed a significant increase in survival. Irradiation doses were comparable in all healthy organs, independently from the mAb used, whereas in tumors the irradiation dose was 7.4-fold higher with (125)I-labeled noninternalizing than with internalizing mAbs. This discrepancy might be due to iodotyrosine moiety release occurring during the catabolism of internalizing mAbs associated with high turnover rate. CONCLUSION: This study indicates that (125)I-labeled noninternalizing mAbs could be suitable for radioimmunotherapy of small solid tumors and that the use of internalizing mAbs should not be considered as a requirement for the success of treatments with (125)I Auger electrons.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-55685" status="OLD">
          <orgName>Institut de recherche en cancérologie de Montpellier</orgName>
          <orgName type="acronym">IRCM - U896 Inserm - UM1</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>208 rue des Apothicaires F-34298 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ircm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-42570" type="direct"/>
            <relation active="#struct-300222" type="direct"/>
            <relation name="U896" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300222" status="VALID">
          <orgName>CRLCC Val d'Aurelle - Paul Lamarque</orgName>
          <desc>
            <address>
              <addrLine>34298 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.valdaurelle.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-106440" status="VALID">
          <orgName>Service de Médecine Nucléaire [Nîmes]</orgName>
          <desc>
            <address>
              <addrLine>Place du Pr R. Debré 30029 Nîmes cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nimes.fr/recherche-clinique-medecine-nucleaire.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-361498" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300040" status="OLD">
          <idno type="IdRef">080712339</idno>
          <idno type="ROR">https://ror.org/01ha22c77</idno>
          <idno type="Wikidata">Q1502878</idno>
          <orgName>Institut de Radioprotection et de Sûreté Nucléaire</orgName>
          <orgName type="acronym">IRSN</orgName>
          <date type="start">2002-02-26</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>F-92260, Fontenay-aux-Roses</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.irsn.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-42570" status="OLD">
          <orgName>Université Montpellier 1</orgName>
          <orgName type="acronym">UM1</orgName>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-montp1.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-361498" status="VALID">
          <idno type="ROR">https://ror.org/0275ye937</idno>
          <orgName>Centre Hospitalier Universitaire de Nîmes</orgName>
          <orgName type="acronym">CHU Nîmes</orgName>
          <desc>
            <address>
              <addrLine>4 Rue du Professeur Robert Debré, 30029 Nîmes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nimes.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>