%0 Journal Article %T Excitable waves at the margin of the contact area between a cell and a substrate. %+ Structures et propriétés d'architectures moléculaire (SPRAM - UMR 5819) %+ Dynamique des systèmes d'adhérence et différenciation (DySAD) %+ Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823) %A Ali, Olivier %A Albiges-Rizo, Corinne %A Block, Marc, R. %A Fourcade, Bertrand %Z The team is supported by a grant from the Ligue Nationale Contre le Cancer, the Association de Recherche pour le Cancer, GEFLUC, ANR, and the Région Rhône-Alpes. A. M.-F. was supported by a fellowship from the Ministère de l'Education Nationale, de la Recherche et de la Technologie. O.A. was supported by grants from the Ministère de l'Education Nationale, de la Recherche et de la Technologie and from the Association de Recherche pour le Cancer. %< avec comité de lecture %@ 1478-3967 %J Physical Biology %I Institute of Physics: Hybrid Open Access %V 6 %N 2 %P 25010 %8 2009 %D 2009 %R 10.1088/1478-3975/6/2/025010 %M 19571372 %K adhesion %K model %K actin %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X In this paper, we study a new physical mechanism to generate an activator field which signals the extreme margin of the contact area between an adherent cell and the substrate. This mechanism is based on the coupling between the adhesive bridges connecting the substrate to the cytoskeleton and a cytosolic activator. Once activated by adhesion on the adhesive bridges, this activator is free to diffuse on the membrane. We propose that this activator is part of the mecano-transduction pathway which links adhesion to actin polymerization and, thus, to cellular motility. The consequences of our model are as follows: (a) the activator is localized at the rim of the contact area, (b) the adhesion is reinforced at the margin of the contact area between the cell and the substrate, (c) excitable waves of the activator can propagate along the adhesion rim. %G English %2 https://inserm.hal.science/inserm-00410942/document %2 https://inserm.hal.science/inserm-00410942/file/prl-final-olivier.pdf %2 https://inserm.hal.science/inserm-00410942/file/inserm-00410942_edited.pdf %L inserm-00410942 %U https://inserm.hal.science/inserm-00410942 %~ INSERM %~ CEA %~ UNIV-RENNES1 %~ UGA %~ CNRS %~ UNIV-GRENOBLE1 %~ IRISA %~ U823 %~ INAC-SPRAM %~ DSM-INAC %~ INC-CNRS %~ UR1-HAL %~ UR1-MATH-STIC %~ UR1-UFR-ISTIC %~ CEA-DRF %~ TEST-UR-CSS %~ INRIA-300009 %~ IRIG %~ CEA-GRE %~ UR1-MATH-NUM