Erectile dysfunction in end-stage liver disease men. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Sexual Medicine Year : 2009

Erectile dysfunction in end-stage liver disease men.


INTRODUCTION: In men, erectile dysfunction (ED) is an important issue. Data concerning ED in men with end-stage liver disease (ESLD) is limited, and the risk factors for ED in this population are still unknown. AIMS: To determine the prevalence, timescale, and risk factors for ED in ESLD patients candidates to liver transplantation. METHODS: Patients candidates for a liver transplantation were asked to participate in a mailed survey about sexual function. Among the 123 eligible men, 98 (84%) agreed to complete the questionnaire. MAIN OUTCOME MEASURES: The quality of erection was evaluated using the five-item International Index of Erectile Function (IIEF-5) score, and satisfaction for sexuality, using the patient-baseline Treatment-Satisfaction Scale (TSS) score. Other questions also focused on patient perception of changes over time. RESULTS: On the overall population, 28 patients (29%) were nonsexually active. Among the 70 patients who were sexually active, 52 patients (74%) had ED. Regarding the development of ED, 50% of the patients perceived that a deterioration of erectile function occurred within the six previous months. The absence of sexual activity was more frequent in hepatitis B or C patients (P = 0.02). The risk factors for ED were alcohol intake (P = 0.03), tobacco use (P = 0.03), and cardiovascular disease (P = 0.004). The significant risk factors for having a low TSS score were having viral hepatitis (P = 0.01), and cardiovascular disease (P = 0.01). CONCLUSION: Population of men with ESLD who are candidates for a liver transplantation is characterized by a high frequency of lack of sexual activity, and by a high prevalence of ED and should be targeted by interventions to improve sexual functioning. These preliminary data need further validation in prospective trial using more comprehensive questionnaires.

Dates and versions

inserm-00409055 , version 1 (05-08-2009)



Eric Huyghe, Nassim Kamar, Fabien Wagner, Aude-Hélène Capietto, Labib El-Kahwaji, et al.. Erectile dysfunction in end-stage liver disease men.. Journal of Sexual Medicine, 2009, 6 (5), pp.1395-401. ⟨10.1111/j.1743-6109.2008.01169.x⟩. ⟨inserm-00409055⟩
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