%0 Journal Article %T Gene regulation by voltage-dependent calcium channels. %+ Grenoble Institut des Neurosciences (GIN) %A Barbado, Maud %A Fablet, Katell %A Ronjat, Michel %A de Waard, Michel %Z Inserm %< avec comité de lecture %@ 0167-4889 %J Biochimica et Biophysica Acta - Molecular Cell Research %I Elsevier %V 1793 %N 6 %P 1096-104 %8 2009-06 %D 2009 %R 10.1016/j.bbamcr.2009.02.004 %M 19250948 %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]Journal articles %X Ca(2+) is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca(2+) in the regulation of long-term cell adaptation through its ability to control gene expression. This finding provided a link between cell excitation and gene expression. In this review, we chose to focus on the role of voltage-dependent calcium channels in mediating gene expression in response to membrane depolarization. We illustrate the different pathways by which these channels are involved in excitation-transcription coupling, including the most recent Ca(2+) ion-independent strategies that highlight the transcription factor role of calcium channels. %G English %2 https://inserm.hal.science/inserm-00394164/document %2 https://inserm.hal.science/inserm-00394164/file/inserm-00394164_edited.pdf %2 https://inserm.hal.science/inserm-00394164/file/BARBADO-BBA-CMR-2008.pdf %2 https://inserm.hal.science/inserm-00394164/file/FIGURE1-pdf.pdf %2 https://inserm.hal.science/inserm-00394164/file/Figure2.pdf %L inserm-00394164 %U https://inserm.hal.science/inserm-00394164 %~ INSERM %~ UGA %~ UNIV-GRENOBLE1 %~ U836