Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles FEBS Letters Year : 2000

Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria.

Abstract

The efficiency of oxidative phosphorylation was compared between rats chronically fed with ethanol and controls. (i) Results showed that the liver mitochondria state 4 respiratory rate was strongly inhibited, while the corresponding proton-motive force was not affected; (ii) the cytochrome oxidase content and activity were decreased and (iii) the oxidative-phosphorylation yield was increased in the ethanol exposed group. Furthermore, oxidative phosphorylation at coupling site II was not affected by ethanol. Cytochrome oxidase inhibition by sodium-azide mimicked the effects of ethanol intoxication in control mitochondria. This indicates that the decrease in cytochrome oxidase activity induced by ethanol intoxication directly increases the efficiency of oxidative phosphorylation.
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Dates and versions

inserm-00390046 , version 1 (06-06-2009)

Identifiers

  • HAL Id : inserm-00390046 , version 1
  • PUBMED : 10692594

Cite

Marie-Astrid Piquet, Véronique Nogueira, Anne Devin, Brigitte Sibille, Céline Filippi, et al.. Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria.. FEBS Letters, 2000, 468 (2-3), pp.239-42. ⟨inserm-00390046⟩

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