%0 Journal Article %T Radical versus partial nephrectomy: effect on overall and noncancer mortality. %+ Cancer Prognostics and Health Outcome Unit %+ Service d'urologie %+ Cancer Prognostics and Health Outcomes Unit %+ Department of urology %+ Institut de Génétique et Développement de Rennes (IGDR) %+ Service d'urologie [Rennes] = Urology [Rennes] %A Zini, Laurent %A Perrotte, Paul %A Capitanio, Umberto %A Jeldres, Claudio %A Shariat, Shahrokh, F. %A Antebi, Elie %A Saad, Fred %A Patard, Jean-Jacques %A Montorsi, Francesco %A Karakiewicz, Pierre, I. %Z Funded by: University of Montreal Health Center Urology Associates/Fonds de la Recherche en Santé du Québec/ University of Montreal Department of Surgery/University of Montreal Health Center (CHUM) Foundation/ Association Française de Recherche sur le Cancer/Fondation de France-Fédération Nationale des Centres de Lutte Contre le Cancer/Association Française d'Urologie/Ministère Français des Affaires Etrangères et Européennes (Bourse Lavoisier) %< avec comité de lecture %J Cancer / Cancer (Phila) %V 115 %N 7 %P 1465-71 %8 2009-04-01 %D 2009 %R 10.1002/cncr.24035 %M 19195042 %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology %Z Life Sciences [q-bio]/Human health and pathology/SurgeryJournal articles %X BACKGROUND: Relative to radical nephrectomy (RN), partial nephrectomy (PN) performed for renal cell carcinoma (RCC) may protect from non-cancer-related deaths. The authors tested this hypothesis in a cohort of PN and RN patients. METHODS: The Surveillance, Epidemiology, and End Results-9 database allowed identification of 2198 PN (22.4%) and 7611 RN (77.6%) patients treated for T1aN0M0 RCC between 1988 and 2004. Analyses matched for age, year of surgery, tumor size, and Fuhrman grade addressed the effect of nephrectomy type (RN vs PN) on overall mortality (Cox regression models) and on non-cancer-related mortality (competing-risks regression models). RESULTS: Relative to PN, RN was associated with 1.23-fold (P = .001) increased overall mortality rate, which translated into a 4.9% and 3.1% absolute increase in mortality at 5 and 10 years after surgery, respectively. Similarly, non-cancer-related death rate was significantly higher after RN in competing-risks regression models (P < .001), which translated into a 4.6% and 4.5% absolute increase in non-cancer-related mortality at 5 and 10 years after surgery, respectively. CONCLUSIONS: Relative to PN, RN predisposes to an increase in overall mortality and non-cancer-related death rate in patients with T1a RCC. In consequence, PN should be attempted whenever technically feasible. Selective referrals should be considered if PN expertise is unavailable. %G English %L inserm-00366097 %U https://inserm.hal.science/inserm-00366097 %~ INSERM %~ UNIV-RENNES1 %~ CNRS %~ HL %~ IGDR %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA %~ PARTENARIATS-APP %~ TEST3-HALCNRS