%0 Journal Article %T Dual and beneficial roles of macrophages during skeletal muscle regeneration. %+ Institut Cochin (UMR_S567 / UMR 8104) %+ Institut Mondor de recherche biomédicale (IMRB) %+ Institut Pasteur [Paris] (IP) %+ Center for Cell and Gene Therapy %A Chazaud, Bénédicte %A Brigitte, Madly %A Yacoub-Youssef, Houda %A Arnold, Ludovic %A Gherardi, Romain %A Sonnet, Corinne %A Lafuste, Peggy %A Chretien, Fabrice %< avec comité de lecture %@ 0091-6331 %J Exercise and Sport Sciences Reviews %I American College of Sports Medicine %V 37 %N 1 %P 18-22 %8 2009-01 %D 2009 %R 10.1097/JES.0b013e318190ebdb %M 19098520 %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair. %G English %L inserm-00354230 %U https://inserm.hal.science/inserm-00354230 %~ INSERM %~ PASTEUR %~ UNIV-PARIS5 %~ CNRS %~ RIIP_PARIS %~ IMRB %~ UPEC %~ UNIV-PARIS %~ UP-SANTE