%0 Journal Article %T Adiponectin normalization: a clue to the anti-metabolic syndrome action of rimonabant. %+ Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1) %A Maynadier, Marie %A Basile, Ilaria %A Gary-Bobo, Magali %< avec comité de lecture %@ 1359-6446 %J Drug Discovery Today %I Elsevier %V 14 %N 3-4 %P 192-7 %8 2009-02 %D 2009 %R 10.1016/j.drudis.2008.09.009 %M 18951999 %K obesity %K metabolic syndrome %K adipose tissue %K adiponectin %K rimonabant %Z Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism %Z Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology %Z Life Sciences [q-bio]/Human health and pathology/Emerging diseases %Z Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Life Sciences [q-bio]/Pharmaceutical sciencesJournal articles %X Obesity, currently associated with metabolic syndrome is characterized by an excessive fat storage in different organs, in particular adipose tissue, inducing the loss of its structural and functional integrity. Being aware of the importance of adipose tissue endocrine function and the key role of adipocytokines, such as adiponectin, in obesity and metabolic syndrome drives the necessity to develop new drugs that can exert a specific action on adipose tissue and on adiponectin levels. Rimonabant, an antiobesity drug, presents a dual effect by decreasing food intake and importantly increasing adiponectin. This review focuses on the key role of adiponectin regulation in the success of rimonabant and suggests that this adipohormone may be considered as a therapeutic target to design innovative and promising antiobesity and anti-metabolic syndrome drugs. %G English %2 https://inserm.hal.science/inserm-00338419/document %2 https://inserm.hal.science/inserm-00338419/file/Gary-Bobo_Manuscript.pdf %2 https://inserm.hal.science/inserm-00338419/file/inserm-00338419_edited.pdf %L inserm-00338419 %U https://inserm.hal.science/inserm-00338419 %~ INSERM %~ UNIV-MONTP1 %~ SANTE_PUB_INSERM %~ FNCLCC %~ VALDAURELLE %~ BS %~ UNIV-MONTPELLIER %~ IRCM %~ UM1-UM2 %~ UM-2015-2021