%0 Journal Article %T [Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature] %+ Systèmes de sécrétion de type IV et virulence bactérienne %+ Laboratoire de bactériologie, virologie et parasitologie %+ Service d'urologie %A Lavigne, Jean-Philippe %A Bourg, G. %A Botto, Henri %A Sotto, Albert %< avec comité de lecture %@ 0369-8114 %J Pathologie Biologie %I Elsevier Masson %V 55 %N 8-9 %P 460-4 %8 2007-11 %D 2007 %R 10.1016/j.patbio.2007.07.005 %M 17905535 %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects. %G French %2 https://inserm.hal.science/inserm-00258570/document %2 https://inserm.hal.science/inserm-00258570/file/Cranberry-PathBiol2007.pdf %L inserm-00258570 %U https://inserm.hal.science/inserm-00258570 %~ INSERM %~ UNIV-MONTP1 %~ APHP %~ UNIV-MONTPELLIER %~ UM1-UM2