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            <title xml:lang="en">Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity.</title>
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              <persName>
                <forename type="first">Corneliu</forename>
                <surname>Henegar</surname>
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                <forename type="first">Joan</forename>
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              <affiliation ref="#struct-27744"/>
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            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Achard</surname>
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              <idno type="halauthorid">301838-0</idno>
              <affiliation ref="#struct-27744"/>
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                <surname>Lacasa</surname>
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              <affiliation ref="#struct-27744"/>
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                <surname>Cremer</surname>
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                <forename type="first">Michele</forename>
                <surname>Guerre-Millo</surname>
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                <forename type="first">Arnaud</forename>
                <surname>Basdevant</surname>
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                <forename type="first">Vladimir</forename>
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                <surname>Langin</surname>
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                <forename type="first">Karine</forename>
                <surname>Clement</surname>
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                <forename>Corneliu</forename>
                <surname>Henegar</surname>
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              <date type="whenSubmitted">2008-02-22 00:09:21</date>
              <date type="whenModified">2025-10-22 18:04:07</date>
              <date type="whenReleased">2008-02-22 09:20:26</date>
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                  <forename>Corneliu</forename>
                  <surname>Henegar</surname>
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            <idno type="halId">inserm-00258387</idno>
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            <idno type="halRefHtml">&lt;i&gt;Genome Biology&lt;/i&gt;, 2008, 9 (1), pp.R14. &lt;a target="_blank" href="https://dx.doi.org/10.1186/gb-2008-9-1-r14"&gt;&amp;#x27E8;10.1186/gb-2008-9-1-r14&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
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                <title xml:lang="en">Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity.</title>
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                  <persName>
                    <forename type="first">Corneliu</forename>
                    <surname>Henegar</surname>
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                    <forename type="first">Arnaud</forename>
                    <surname>Basdevant</surname>
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                    <forename type="first">Vladimir</forename>
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                    <forename type="first">Nathalie</forename>
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                    <forename type="first">Dominique</forename>
                    <surname>Langin</surname>
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                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Bedossa</surname>
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                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Daniel</forename>
                    <surname>Zucker</surname>
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                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?hl=fr&amp;user=bcrbZrEAAAAJ</idno>
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                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-3008-2016</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Karine</forename>
                    <surname>Clement</surname>
                  </persName>
                  <idno type="halauthorid">190017-0</idno>
                  <affiliation ref="#struct-27744"/>
                  <affiliation ref="#struct-99711"/>
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                <idno type="halJournalId" status="VALID">13604</idno>
                <idno type="issn">1465-6906</idno>
                <idno type="eissn">1474-760X</idno>
                <title level="j">Genome Biology</title>
                <imprint>
                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">9</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">R14</biblScope>
                  <date type="datePub">2008-01-21</date>
                  <date type="dateEpub">2008-01-21</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/gb-2008-9-1-r14</idno>
              <idno type="ird">fdi:010044566</idno>
              <idno type="pubmed">18208606</idno>
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              <classCode scheme="halDomain" n="sdv.bibs">Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="info.info-bi">Computer Science [cs]/Bioinformatics [q-bio.QM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
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            <abstract xml:lang="en">
              <p>ABSTRACT: BACKGROUND: Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT); however, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear. RESULTS: Here, we analyzed the transcriptomic signature of the WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. An original integrative functional genomic approach was applied to quantify relations between relevant structural and functional themes annotating differentially expressed genes, to construct a comprehensive map of transcriptional interactions defining the obese WAT. These analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of integrins family, and suggested that these elements could play a major mediating role in a chain of interactions which connects local inflammatory phenomena to the alteration of WAT metabolic functions in obese subjects. Tissue and cellular investigations, driven by the analysis of transcriptional interactions, revealed an increased amount of interstitial fibrosis in obese WAT, associated with an infiltration of different types of inflammatory cells, and suggested that phenotypic alterations of human preadipocytes, induced by a proinflammatory environment, may lead to an excessive synthesis of ECM components. CONCLUSIONS: This study opens new perspectives in understanding the biology of human WAT and its pathologic changes indicative of tissue deterioration, associated with the development of obesity.</p>
            </abstract>
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