<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-00179254</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T05:20:19+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.</title>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Skowron-Zwarg</surname>
              </persName>
              <idno type="halauthorid">234194-0</idno>
              <affiliation ref="#struct-20033"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sonja</forename>
                <surname>Boland</surname>
              </persName>
              <email type="md5">c664700a24ab9bb62cd87098bdfe8ed4</email>
              <email type="domain">univ-paris-diderot.fr</email>
              <idno type="idhal" notation="string">sonja-boland</idno>
              <idno type="idhal" notation="numeric">14166</idno>
              <idno type="halauthorid" notation="string">5338-14166</idno>
              <idno type="IDREF">https://www.idref.fr/150517297</idno>
              <affiliation ref="#struct-20033"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Caruso</surname>
              </persName>
              <idno type="halauthorid">234195-0</idno>
              <affiliation ref="#struct-20033"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christelle</forename>
                <surname>Coraux</surname>
              </persName>
              <email type="md5">7a721fe1648bcfe2a559d040863b0a51</email>
              <email type="domain">univ-reims.fr</email>
              <idno type="idhal" notation="numeric">757148</idno>
              <idno type="halauthorid" notation="string">170882-757148</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5345-5074</idno>
              <idno type="IDREF">https://www.idref.fr/11092262X</idno>
              <idno type="VIAF">https://viaf.org/viaf/172556051</idno>
              <affiliation ref="#struct-2882"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Francelyne</forename>
                <surname>Marano</surname>
              </persName>
              <idno type="halauthorid">165811-0</idno>
              <affiliation ref="#struct-20033"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Tournier</surname>
              </persName>
              <idno type="halauthorid">234196-0</idno>
              <affiliation ref="#struct-20033"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Philippe</forename>
                <surname>Birembaut</surname>
              </persName>
              <email type="md5">aa0145359498130848923c2ae7f940a3</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2007-10-15 10:14:45</date>
              <date type="whenModified">2024-04-19 13:46:18</date>
              <date type="whenReleased">2007-10-15 15:03:33</date>
              <date type="whenProduced">2007-07-15</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-C40RQRW3-7/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="117278">
                <persName>
                  <forename>Philippe</forename>
                  <surname>Birembaut</surname>
                </persName>
                <email type="md5">aa0145359498130848923c2ae7f940a3</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00179254</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-00179254</idno>
            <idno type="halBibtex">skowronzwarg:inserm-00179254</idno>
            <idno type="halRefHtml">&lt;i&gt;Experimental Cell Research&lt;/i&gt;, 2007, 313 (12), pp.2695-702. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.yexcr.2007.02.035"&gt;&amp;#x27E8;10.1016/j.yexcr.2007.02.035&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Experimental Cell Research, 2007, 313 (12), pp.2695-702. &amp;#x27E8;10.1016/j.yexcr.2007.02.035&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="URCA">Publications de l'Université de Reims Champagne-Ardenne</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Skowron-Zwarg</surname>
                  </persName>
                  <idno type="halauthorid">234194-0</idno>
                  <affiliation ref="#struct-20033"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sonja</forename>
                    <surname>Boland</surname>
                  </persName>
                  <email type="md5">c664700a24ab9bb62cd87098bdfe8ed4</email>
                  <email type="domain">univ-paris-diderot.fr</email>
                  <idno type="idhal" notation="string">sonja-boland</idno>
                  <idno type="idhal" notation="numeric">14166</idno>
                  <idno type="halauthorid" notation="string">5338-14166</idno>
                  <idno type="IDREF">https://www.idref.fr/150517297</idno>
                  <affiliation ref="#struct-20033"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Caruso</surname>
                  </persName>
                  <idno type="halauthorid">234195-0</idno>
                  <affiliation ref="#struct-20033"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christelle</forename>
                    <surname>Coraux</surname>
                  </persName>
                  <email type="md5">7a721fe1648bcfe2a559d040863b0a51</email>
                  <email type="domain">univ-reims.fr</email>
                  <idno type="idhal" notation="numeric">757148</idno>
                  <idno type="halauthorid" notation="string">170882-757148</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5345-5074</idno>
                  <idno type="IDREF">https://www.idref.fr/11092262X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/172556051</idno>
                  <affiliation ref="#struct-2882"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Francelyne</forename>
                    <surname>Marano</surname>
                  </persName>
                  <idno type="halauthorid">165811-0</idno>
                  <affiliation ref="#struct-20033"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Tournier</surname>
                  </persName>
                  <idno type="halauthorid">234196-0</idno>
                  <affiliation ref="#struct-20033"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">4755</idno>
                <idno type="issn">0014-4827</idno>
                <idno type="eissn">1090-2422</idno>
                <title level="j">Experimental Cell Research</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">313</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">2695-702</biblScope>
                  <date type="datePub">2007-07-15</date>
                  <date type="dateEpub">2007-03-21</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.yexcr.2007.02.035</idno>
              <idno type="pubmed">17553491</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Aquaporin 5</classCode>
              <classCode scheme="mesh">Cell Differentiation</classCode>
              <classCode scheme="mesh">Respiratory System</classCode>
              <classCode scheme="mesh">Cells, Cultured</classCode>
              <classCode scheme="mesh">Cystic Fibrosis Transmembrane Conductance Regulator</classCode>
              <classCode scheme="mesh">Epithelial Cells</classCode>
              <classCode scheme="mesh">Gene Expression Regulation</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Interleukin-13</classCode>
              <classCode scheme="mesh">Protein Transport</classCode>
              <classCode scheme="mesh">RNA, Messenger</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.psr">Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Interleukin-13 (IL-13) is a central regulator of Th2-dominated respiratory disorders such as asthma. Lesions of the airway epithelial barrier frequently observed in chronic respiratory inflammatory diseases are repaired through proliferation, migration and differentiation of epithelial cells. Our work is focused on the effects of IL-13 in human cellular models of airway epithelial cell regeneration. We have previously shown that IL-13 altered epithelial cell polarity during mucociliary differentiation of human nasal epithelial cells. In particular, the cytokine inhibited ezrin expression and interfered with its apical localization during epithelial cell differentiation in vitro. Here we show that CFTR expression is enhanced in the presence of the cytokine, that two additional CFTR protein isoforms are expressed in IL-13-treated cells and that part of the protein is retained within the endoplasmic reticulum. We further show that aquaporin 5 expression, a water channel localized within the apical membrane of epithelial cells, is completely abolished in the presence of the cytokine. These results show that IL-13 interferes with ion and water channel expression and localization during epithelial regeneration and may thereby influence mucus composition and hydration.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-20033" status="INCOMING">
          <orgName>Laboratoire de Cytophysiologie et Toxicologie Cellulaire</orgName>
          <desc>
            <address>
              <addrLine>Tour 53-54, 3ème étage, case 7073, 2 place Jussieu, 75251 Paris cedex 05</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300301" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2882" status="OLD">
          <orgName>Dynamique cellulaire et moléculaire de la muqueuse respiratoire</orgName>
          <desc>
            <address>
              <addrLine>Hopital Maison Blanche 45, Rue Cognacq Jay 51092 Reims Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-reims.fr/Labos/INSERM514/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7569" type="direct"/>
            <relation active="#struct-300611" type="direct"/>
            <relation name="U514" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-7569" status="VALID">
          <idno type="IdRef">026403838</idno>
          <idno type="ISNI">0000000121767954</idno>
          <idno type="ROR">https://ror.org/03hypw319</idno>
          <orgName>Université de Reims Champagne-Ardenne</orgName>
          <orgName type="acronym">URCA</orgName>
          <desc>
            <address>
              <addrLine>2 avenue Robert Schuman, 51100 Reims.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-reims.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300611" status="VALID">
          <orgName>IFR53</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>