%0 Journal Article %T Comparing strategies for association mapping in samples with related individuals. %+ Génétique épidémiologique et structures des populations humaines (Inserm U535) %A Bourgain, Catherine %< avec comité de lecture %@ 1471-2156 %J BMC Genetics %I BioMed Central %V 6 Suppl 1 %P S98 %8 2005 %D 2005 %R 10.1186/1471-2156-6-S1-S98 %M 16451714 %Z Life Sciences [q-bio]/GeneticsJournal articles %X In this paper, different strategies to test for association in samples with related individuals designed for linkage studies are compared. Because no independent controls are available, a family-based association test and case-control tests corrected for the presence of related individuals in which unaffected relatives are used as controls were tested. When unrelated controls are available, additional strategies including selection of a single case per family considering either all families or a subset of linked families, are also considered. Analyses are performed on the simulated dataset, blind to the answers. The case-control test corrected for the presence of related individuals is the most powerful strategy to detect three loci associated with the disease under study. Using a correction factor for the case-control test performed conditional on the marker information rather than unconditional does not impact the power significantly. %G English %2 https://inserm.hal.science/inserm-00089271/document %2 https://inserm.hal.science/inserm-00089271/file/1471-2156-6-S1-S98.pdf %L inserm-00089271 %U https://inserm.hal.science/inserm-00089271 %~ INSERM %~ UNIV-PARIS5 %~ UNIV-PARIS1 %~ CNRS %~ UNIV-PSUD %~ EHESS %~ IFR69 %~ APHP %~ UNIV-PARIS-SACLAY %~ UNIV-PSUD-SACLAY %~ UNIV-PARIS