%0 Journal Article %T Studying non-mammalian models? Not a fool's ERRand! %+ Mammalian Development %+ Laboratoire de Biologie Moléculaire de la Cellule (LBMC) %+ Genotypes et Phenotypes Tumoraux %A Bardet, Pierre-Luc %A Laudet, Vincent %A Vanacker, Jean-Marc %Z JMV wish to thank the Association pour la Recherche sur le Cancer, the Ligue contre le Cancer, comité Drôme and Languedoc-Roussillon for funding work his lab. PLB is funded by the Association pour la Recherche sur le Cancer. VL thanks the Centre National %< avec comité de lecture %J Trends Endocrinol Metab %V 17 %N 4 %P 166-71 %8 2006-05 %D 2006 %R 10.1016/j.tem.2006.03.005 %M 16580224 %K orphan nuclear receptor %K Estrogen-Related Receptor %K non-mammalian models %K comparative endocrinology %Z Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismJournal articles %X Through studies in mammalian model systems, the estrogen-receptor-related receptor (ERR) alpha, an orphan nuclear receptor, has been shown to interfere with estrogen signaling and might therefore be an interesting pharmaceutical target in estrogen-related diseases. ERRalpha is also involved in energy storage and consumption, and its modulation might be of relevance in the treatment of obesity and diabetes. Recent data have also been published on the effects of this receptor, as well as other members of the ERR family, in non-mammalian animal model systems. Besides indications concerning their mechanisms of action, this analysis demonstrated a role for ERRalpha in controlling cellular movements, and suggested that ERRs might be implicated in a more subtle range of processes than originally envisioned. %G English %2 https://inserm.hal.science/inserm-00000107/document %2 https://inserm.hal.science/inserm-00000107/file/JMVTextRevised.pdf %2 https://inserm.hal.science/inserm-00000107/file/JMVTab.Revised.pdf %L inserm-00000107 %U https://inserm.hal.science/inserm-00000107 %~ INSERM %~ ENS-LYON %~ CNRS %~ UNIV-LYON1 %~ UNIV-MONTP1 %~ PRUNEL %~ UNIV-MONTPELLIER %~ UDL %~ UNIV-LYON %~ UM1-UM2