Human genetic structure in Northwest France provides new insights into West European historical demography - Inserm - Institut national de la santé et de la recherche médicale
Journal Articles Nature Communications Year : 2024

Human genetic structure in Northwest France provides new insights into West European historical demography

1 UNISTRA - Université de Strasbourg
2 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
3 ITX-lab - ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
4 GMGM - Génétique moléculaire, génomique, microbiologie
5 TIMC - Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525
6 Uppsala University
7 CIC 0004 - Nantes - Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique
8 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
9 CNRGH - Centre National de Recherche en Génomique Humaine
10 GENMED - Laboratoire d'excellence en GENomique MEDicale
11 CReAAH - Centre de Recherche en Archéologie, Archéosciences, Histoire
12 LARA - Laboratoire de recherche ARchéologie et Architecture
13 Inrap - Institut national de recherches archéologiques préventives
14 CEPAM - Culture et Environnements, Préhistoire, Antiquité, Moyen-Age
15 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
16 CEPH - Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris]
17 Nantes Univ - Nantes Université
18 Université Paris-Saclay
19 UBO - Université de Brest
20 ITSN - PHU 2 - Institut du Thorax et du Sytème Nerveux [CHU Nantes]
21 Globe Institute
22 UCPH - University of Copenhagen = Københavns Universitet
23 Etablissement Français du Sang (EFS) [Créteil]
24 Etablissement Français du Sang Bretagne
25 CAM - University of Cambridge [UK]
26 CRBC Brest - Centre de recherche bretonne et celtique
27 Trajectoires - UMR 8215
28 LETG - Littoral, Environnement, Télédétection, Géomatique UMR 6554
29 CNRS - Centre National de la Recherche Scientifique
30 CPJP - Centre de Philosophie Juridique et Politique
31 UPCité - Université Paris Cité
32 IT - INSERM-TRANSFERT [Paris]
33 Institut du Thorax [Nantes]
34 EA - Éco-Anthropologie
35 CRefIX - Centre de référence, d’innovation, d’expertise et de transfert
36 UMS CNRS 3628 - INRAE 1396 - Inserm 026 - France Génomique
Carolina Bernhardsson
Emma Svensson
  • Function : Author
Thomas Ludwig
Gaëlle Marenne
Eske Willerslev
Yves Coativy
Marie Zins
Mattias Jakobsson
Pierre Darlu
  • Function : Author
  • PersonId : 1103099
  • IdRef : 032654952

Abstract

The demographical history of France remains largely understudied despite its central role toward understanding modern population structure across Western Europe. Here, by exploring publicly available Europe-wide genotype datasets together with the genomes of 3234 present-day and six newly sequenced medieval individuals from Northern France, we found extensive fine-scale population structure across Brittany and the downstream Loire basin and increased population differentiation between the northern and southern sides of the river Loire, associated with higher proportions of steppe vs. Neolithic-related ancestry. We also found increased allele sharing between individuals from Western Brittany and those associated with the Bell Beaker complex. Our results emphasise the need for investigating local populations to better understand the distribution of rare (putatively deleterious) variants across space and the importance of common genetic legacy in understanding the sharing of disease-related alleles between Brittany and people from western Britain and Ireland.

Dates and versions

hal-04683810 , version 2 (27-09-2024)
hal-04683810 , version 1 (01-10-2024)

Identifiers

Cite

Isabel Alves, Joanna Giemza, Michael Blum, Carolina Bernhardsson, Stéphanie Chatel, et al.. Human genetic structure in Northwest France provides new insights into West European historical demography. Nature Communications, 2024, 15 (1), pp.6710. ⟨10.1038/s41467-024-51087-1⟩. ⟨hal-04683810v1⟩
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