A new perfusion system to reduce the burden of central-venous-line-associated bloodstream infections in neonates - Inserm - Institut national de la santé et de la recherche médicale
Journal Articles Journal of Hospital Infection Year : 2024

A new perfusion system to reduce the burden of central-venous-line-associated bloodstream infections in neonates

Abstract

Background: Central-venous-line-associated bloodstream infection (CLABSI) is a significant cause of morbidity and mortality in preterm infants. As there is large variation in the reported effect of multi-modal preventive strategies, it could be relevant to propose new additional strategies. Aim: To assess the impact of a new perfusion system on CLABSI rate. Methods: A before-and-after study was performed in infants born at <32 weeks of gestation or with birth weight <1500 g who required a multi-perfusion system connected to a central venous line. In the first 12-month period ('before'), the pre-existing perfusion system (multiple stopcocks) was used. An intervention period then occurred with implementation of a new perfusion closed system, without change in 'bundles' related to various aspects of central line care. During the second 12-month period ('after'), the CLABSI rate was assessed and compared with the pre-intervention period. Findings: In total, 313 infants were included in this study (before: N=163; after: N=150), and 46% had birth weight <1000 g. The change in perfusion system resulted in a significant decrease in CLABSI rate from 11.3 to 2.2 per 1000 catheter-days (P<0.001). The period was independently associated with an 88% reduction in the risk of CLABSI after implementation of the new perfusion system [odds ratio (OR) 0.12, 95% confidence interval (CI) 0.03-0.39; P<0.001]. The duration of central line use was also associated with CLABSIs (for each additional day: OR 1.05, 95% CI 1.02-1.07; P<0.001). Conclusions: Implementation of the new perfusion system was feasible in a large neonatal unit, and reduced the CLABSI rate soon after implementation.
Fichier principal
Vignette du fichier
2024_Picaud_J_Hospital_Inf.pdf (1.17 Mo) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

hal-04672922 , version 1 (08-10-2024)

Licence

Identifiers

Cite

J. C. Picaud, S. Faton, P. Pradat, B. Pastor-Diez, A. Martelin, et al.. A new perfusion system to reduce the burden of central-venous-line-associated bloodstream infections in neonates. Journal of Hospital Infection, 2024, 143, pp.203-212. ⟨10.1016/j.jhin.2023.10.004⟩. ⟨hal-04672922⟩
36 View
3 Download

Altmetric

Share

More