%0 Journal Article %T Antioxidants other than vitamin c may be detected by glucose meters: immediate relevance for patients with disorders targeted by antioxidant therapies %+ Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD) %+ Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) %+ Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA) %+ Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME) %A Grzych, Guillaume %A Pekar, Jean-David %A Joncquel-Chevalier Curt, Marie %A Decoin, Raphael %A Vergriete, Pauline %A Henry, Héloïse %A Odou, Pascal %A Maboudou, Patrice %A Brousseau, Thierry %A Vamecq, Joseph %Z The authors thank the University Hospital (CHU) of Lille for supporting the present study. %< avec comité de lecture %@ 1873-2933 %J Clinical biochemistry %S Clinical biochemistry %V 92 %P 71-76 %8 2021-06-01 %D 2021 %R 10.1016/j.clinbiochem.2021.03.007 %M 33766514 %K Dihydrolipoate %K Glutathione %K COVID-19 %K Hypoglycemic drug overdoses %K Glycemic mismanagement %K Glycemic control %K Falsely-elevated glycemia %K Points-of-care %K Dithiothreitol %K N-acetylcysteine %K Vitamin-C %K Antioxidant %K Glucose meter %K Cysteine %Z Life Sciences [q-bio]Journal articles %X Owing to their ease of use, glucose meters are frequently used in research and medicine. However, little is known of whether other non-glucose molecules, besides vitamin C, interfere with glucometry. Therefore, we sought to determine whether other antioxidants might behave like vitamin C in causing falsely elevated blood glucose levels, potentially exposing patients to glycemic mismanagement by being administered harmful doses of glucose-lowering drugs. To determine whether various antioxidants can be detected by seven commercial glucose meters, human blood samples were spiked with various antioxidants ex vivo and their effect on the glucose results were assessed by Parkes error grid analysis. Several of the glucose meters demonstrated a positive bias in the glucose measurement of blood samples spiked with vitamin C, N-acetylcysteine, and glutathione. With the most interference-sensitive glucose meter, non-blood solutions of 1 mmol/L N-acetylcysteine, glutathione, cysteine, vitamin C, dihydrolipoate, and dithiothreitol mimicked the results seen on that glucose meter for 0.7, 1.0, 1.2, 2.6, 3.7 and 5.5 mmol/L glucose solutions, respectively. Glucose meter users should be alerted that some of these devices might produce spurious glucose results not only in patients on vitamin C therapy but also in those being administered other antioxidants. As discussed herein, the clinical relevance of the data is immediate in view of the current use of antioxidant therapies for disorders such as the metabolic syndrome, diabetes, cardiovascular diseases, and coronavirus disease 2019. %G English %2 https://hal.univ-lille.fr/hal-03405515/document %2 https://hal.univ-lille.fr/hal-03405515/file/S000991202100076X.pdf %L hal-03405515 %U https://hal.univ-lille.fr/hal-03405515 %~ INSERM %~ RIIP %~ RIIP_LILLE %~ UNIV-LILLE %~ RNMCD %~ ELSEVIER