Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs - Genetics of Autism
Article Dans Une Revue Nature Genetics Année : 2013

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Hong S. Lee (1) , Stephan Ripke (2, 3, 4) , Benjamin M. Neale (2, 3, 4) , Stephen V. Faraone (5) , Shaun M. Purcell (2, 3, 4, 6) , Roy H. Perlis (4, 7) , Bryan J. Mowry (1, 8) , Anita Thapar (9, 10) , Michael E. Goddard (11) , John S. Witte (12, 13) , Devin Absher (14) , Ingrid Agartz (15, 16) , Huda Akil (17, 18) , Farooq Amin (19) , Ole A. Andreassen (15, 20) , Adebayo Anjorin (21) , Richard Anney (22) , Verneri Anttila (2, 3) , Dan E. Arking (23) , Philip Asherson (24) , Maria H. Azevedo (25) , Lena Backlund (26) , Judith A. Badner (27) , Anthony J. Bailey (28) , Tobias Banaschewski (29) , Jack D. Barchas (30) , Michael R. Barnes (31) , Thomas B. Barrett (32) , Nicholas Bass (33, 21) , Agatino Battaglia (34) , Michael Bauer (35) , Mònica Bayés (36) , Frank Bellivier (37, 38, 39, 40) , Sarah E. Bergen (4, 2, 26) , Wade Berrettini (41) , Catalina Betancur (42, 37, 43) , Thomas Bettecken (44) , Joseph Biederman (45) , Elisabeth B. Binder (44) , Donald W. Black (46) , Douglas H. R. Blackwood (47, 48) , Cinnamon S. Bloss (49) , Michael Boehnke (17) , Dorret I. Boomsma , Gerome Breen (50, 51, 52) , René Breuer (53) , Richard Bruggeman (54) , Paul Cormican (55) , Nancy G. Buccola (56) , Jan K. Buitelaar (57) , William E. Bunney (58) , Joseph D. Buxbaum (59, 60, 61, 62, 63, 64, 65) , William F. Byerley (66) , Enda M. Byrne (1) , Sian Caesar (67) , Wiepke Cahn (61) , Rita M. Cantor (68) , Miguel Casas (61) , Aravinda Chakravarti (69, 70) , Kimberly Chambert (71) , Khalid Choudhury (72) , Sven Cichon (73, 74, 75) , Robert C. Cloninger (61) , David A. Collier (50, 52, 76) , Edwin H. Cook (77) , Hilary Coon (78) , Bru Cormand (61) , Aiden Corvin (55, 79) , William H. Coryell (80) , David W. Craig (81) , Ian W. Craig (50) , Jennifer Crosbie (81) , Michael L. Cuccaro (82) , David Curtis (83) , Darina Czamara (84) , Susmita Datta (85) , Geraldine Dawson (86) , Richard Day (87) , Eco J. de Geus (88) , Franziska Degenhardt (73, 74) , Srdjan Djurovic (89, 90) , Gary J. Donohoe (55, 91) , Alysa E. Doyle (92) , Jubao Duan (93) , Frank Dudbridge (94) , Eftichia Duketis (95) , Richard P. Ebstein (96) , Howard J. Edenberg (97) , Josephine Elia (81) , Sean Ennis (98) , Bruno Etain (99, 100) , Ayman Fanous (101) , Anne E. Farmer (50, 52) , I Nicol Ferrier (102) , Matthew Flickinger (103) , Eric Fombonne (104) , Tatiana Foroud (105) , Josef Frank (106) , Barbara Franke (106) , Christine Fraser (9, 10) , Robert Freedman (107) , Nelson B. Freimer (108) , Christine M. Freitag (95) , Marion Friedl (109) , Louise Frisén (110) , Louise Gallagher (55) , Pablo V. Gejman (93) , Lyudmila Georgieva (9, 10) , Elliot S. Gershon (111) , Daniel H. Geschwind (112) , Ina Giegling (109) , Michael Gill (55) , Scott D. Gordon (106) , Katherine Gordon-Smith (10, 67, 113) , Elaine K. Green (113) , Tiffany A. Greenwood (81) , Dorothy E. Grice (114) , Magdalena Gross (115) , Detelina Grozeva (10, 113) , Weihua Guan (103, 115) , Hugh Gurling (72) , Lieuwe de Haan (114) , Jonathan L. Haines (116) , Hakon Hakonarson (117, 118) , Joachim Hallmayer (119) , Steven P. Hamilton (120) , Marian L. Hamshere (10, 113, 121) , Thomas F. Hansen (122) , Annette M. Hartmann (109) , Martin Hautzinger (123) , Andrew C. Heath (70) , Anjali K. Henders (114) , Stefan Herms (109) , Ian B. Hickie (124) , Maria Hipolito (106) , Susanne Hoefels (114) , Peter A. Holmans (125, 10) , Florian Holsboer (126) , Witte J. Hoogendijk (127) , Jouke-Jan Hottenga (70) , Christina M. Hultman (128) , Vanessa Hus (129) , Andrés Ingason (122) , Marcus Ising (130) , Stéphane Jamain (99) , Edward G. Jones (131) , Ian Jones (9, 10) , Lisa Jones (67) , Jung-Ying Tzeng (132) , Anna K. Kähler (133) , René Sylvain Kahn (134) , Radhika Kandaswamy (135, 72) , Matthew C. Keller (133) , James L. Kennedy (136) , Elaine Kenny (55, 91) , Lindsey Kent (137) , Yunjung Kim (132) , George K. Kirov (9, 10, 138) , Sabine M. Klauck (139) , Lambertus Klei (114) , James A. Knowles (140) , Martin A. Kohli (130) , Daniel L. Koller (105) , Bettina Konte (88) , Ania Korszun (113) , Lydia Krabbendam (133) , Robert Krasucki (72) , Jonna Kuntsi (50) , Phoenix Kwan (103) , Mikael Landén (128, 141) , Niklas Långström (141) , Mark Lathrop (142) , Jacob Lawrence (135, 72) , William B. Lawson (106) , Marion Leboyer (99, 100) , David H. Ledbetter (143) , Phil H. Lee (7) , Todd Lencz (144) , Klaus-Peter Lesch (145) , Douglas F. Levinson (143) , Cathryn M. Lewis (50, 113, 146) , Jun Li (147) , Paul Lichtenstein (128) , Jeffrey A. Lieberman (145) , Dan-Yu Lin (132) , Don H. Linszen (145) , Chunyu Liu (132) , Falk W. Lohoff (41) , Sandra K. Loo (132) , Catherine Lord (129) , Jennifer K. Lowe (115) , Susanne Lucae (44) , Donald J. Macintyre (143) , Pamela A. F. Madden (88) , Elena Maestrini (148) , Patrik K. E. Magnusson (149) , Pamela B. Mahon (150) , Wolfgang Maier (149) , Anil K. Malhotra (144) , Shrikant M. Mane (151) , Christa L. Martin (152) , Nicholas G. Martin (153, 154) , Manuel Mattheisen (74, 155) , Keith Matthews (102) , Morten Mattingsdal (89, 15, 156) , Steven A. Mccarroll (71) , Kevin A. Mcghee (157, 158) , James J. Mcgough (152) , Patrick J. Mcgrath (152) , Peter Mcguffin (50, 52) , Melvin G. Mcinnis (159) , Andrew Mcintosh (157, 158) , Rebecca Mckinney (81) , Alan W. Mclean (157, 158) , Francis J. Mcmahon (160, 91) , William M. Mcmahon (78) , Andrew Mcquillin (72) , Helena Medeiros (161) , Sarah E. Medland (88) , Sandra Meier (53) , Ingrid Melle (89, 162, 15, 163) , Fan Meng (164) , Jobst Meyer (152) , Christel M. Middeldorp (70) , Lefkos Middleton (165) , Vihra Milanova (166) , Ana Miranda (167) , Anthony P. Monaco (168) , Grant W. Montgomery (153, 154) , Jennifer L. Moran (71) , Daniel Moreno-De-Luca (42) , Gunnar Morken (133, 169) , Derek W. Morris (55, 79) , Eric M. Morrow (170, 171) , Valentina Moskvina (10, 138) , Pierandrea Muglia (121) , Thomas W. Mühleisen (74, 73) , Walter J. Muir (157, 158) , Bertram Müller-Myhsok (172) , Michael Murtha (145) , Richard M. Myers (14) , Inez Myin-Germeys (44) , Michael C. Neale (101) , Stan F. Nelson (145) , Caroline M. Nievergelt (81) , Ivan Nikolov (9, 10) , Vishwajit Nimgaonkar (173) , Willem A. Nolen (174) , Markus M. Nöthen (138, 145) , John I. Nurnberger (105) , Evaristus A. Nwulia (106) , Dale R. Nyholt (88) , Colm O'Dushlaine (71) , Robert D. Oades (44) , Ann Olincy (107) , Guiomar Oliveira (175, 161) , Line Olsen (101, 122) , Roel A. Ophoff (176) , Urban Osby (110) , Michael J. Owen (9, 10) , Aarno Palotie (177) , Jeremy R. Parr (152) , Andrew D. Paterson (178, 179) , Carlos N. Pato (101) , Michele T. Pato (101) , Brenda W. Penninx (153) , Michele L. Pergadia (88) , Margaret A. Pericak-Vance (82) , Benjamin S. Pickard (157, 158) , Jonathan Pimm (72) , Joseph Piven (180) , Danielle Posthuma (125) , James B. Potash (181, 182) , Fritz Poustka (95) , Peter Propping (74) , Vinay Puri (72) , Digby J. Quested (107) , Emma M. Quinn (144, 55, 79) , Josep Antoni Ramos-Quiroga (61) , Henrik B. Rasmussen (61, 122) , Soumya Raychaudhuri (71, 183) , Karola Rehnström (184) , Andreas Reif (185) , Marta Ribasés (107) , John P. Rice (186) , Marcella Rietschel (53) , Kathryn Roeder (187) , Herbert Roeyers (188) , Lizzy Rossin (71) , Aribert Rothenberger (189) , Guy Rouleau (190) , Douglas Ruderfer (144) , Dan Rujescu (109) , Alan R. Sanders (93) , Stephan J. Sanders (191) , Susan L. Santangelo (192, 193) , Joseph A. Sergeant (194) , Russell Schachar (61) , Martin Schalling (110) , Alan F. Schatzberg (195) , William A. Scheftner (184) , Gerard D. Schellenberg (196) , Stephen W. Scherer (178, 179) , Nicholas J. Schork (197) , Thomas G. Schulze (53, 91, 181, 198) , Johannes Schumacher (74) , Markus Schwarz (199) , Edward Scolnick (71) , Laura J. Scott (103) , Jianxin Shi (200) , Paul D. Shilling (81) , Stanley I. Shyn (61) , Jeremy M. Silverman (114) , Susan L. Slager (61) , Susan L. Smalley (61) , Johannes H. Smit (153, 88) , Erin N. Smith (201) , Edmund J. S. Sonuga-Barke (143, 202) , David St Clair (51) , Matthew State (145) , Michael Steffens (155) , Hans-Christoph Steinhausen (203) , John S. Strauss (204) , Jana Strohmaier (53) , Scott T. Stroup (107) , James S. Sutcliffe (116, 205, 206) , Peter Szatmari (207) , Szabocls Szelinger (208) , Srinivasa Thirumalai (209) , Robert C. Thompson (164, 58) , Alexandre A. Todorov (210) , Federica Tozzi (121) , Jens Treutlein (184) , Manfred Uhr (130) , Edwin J. C. G. van den Oord (61) , Gerard van Grootheest (145) , Jim van Os (145) , Astrid M. Vicente (211, 212) , Veronica J. Vieland (213) , John B. Vincent (214) , Peter M. Visscher (1, 215, 216) , Christopher A. Walsh (122) , Thomas H. Wassink (217) , Stanley J. Watson (164) , Myrna M. Weissman (149) , Thomas Werge (122) , Thomas F. Wienker (109, 155) , Ellen M. Wijsman (218) , Gonneke Willemsen (153) , Nigel Williams (9, 10) , Jeremy A. Willsey (145) , Stephanie H. Witt (53) , Wei Xu (219) , Allan H. Young (102, 220) , Timothy W. Yu (61) , Stanley Zammit (9, 10) , Peter P. Zandi (221) , Peng Zhang (17) , Frans G. Zitman (88) , Sebastian Zöllner (159) , Bernie Devlin (114) , John R. Kelsoe (222, 223) , Pamela Sklar (144) , Mark J. Daly (71, 183) , Michael C. O'Donovan (9, 10) , Nicholas Craddock (10, 9) , Patrick F. Sullivan (88) , Jordan W. Smoller (71, 7) , Kenneth S. Kendler (144) , Naomi R. Wray (1)
1 Queensland Brain Institute
2 Massachusetts General Hospital [Boston]
3 HMS - Harvard Medical School [Boston]
4 BROAD INSTITUTE - Broad Institute of MIT and Harvard
5 SUNY Upstate Medical University
6 Mount Sinai School of Medicine
7 Psychiatric and Neurodevelopmental Genetics Unit
8 Queensland Centre for Mental Health Research
9 Institute of Psychological Medicine and Clinical Neurosciences
10 MRC Centre for Neuropsychiatric Genetics and Genomics
11 NSW DPI - New South Wales Department of Primary Industries
12 Faculty of Land and Food Resources
13 University of Melbourne
14 HudsonAlpha Institute for Biotechnology [Huntsville, AL]
15 Institute of Clinical Medicine [Oslo]
16 Diakonhjemmet Hospital
17 University of Michigan [Ann Arbor]
18 MBNI - Molecular and Behavioral Neuroscience Institute
19 Emory University [Atlanta, GA]
20 Oslo University Hospital [Oslo]
21 UCL - University College of London [London]
22 Trinity College Dublin
23 Johns Hopkins University School of Medicine [Baltimore]
24 MRC Social Genetic Developmental and Psychiatry Centre
25 UC - University of Coimbra [Portugal]
26 Karolinska Institutet [Stockholm]
27 University of Chicago
28 UBC - University of British Columbia
29 Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]
30 Weill Medical College of Cornell University [New York]
31 GlaxoSmithKline
32 Portland Veterans Administration Medical Center
33 Windeyer Institute for Medical Sciences
34 IRCCS Fondazione Stella Maris [Pisa]
35 University Hospital Carl Gustav Carus [Dresden, Germany]
36 CNAG - Centro Nacional de Analisis Genomico [Barcelona]
37 INSERM - Institut National de la Santé et de la Recherche Médicale
38 UPD7 - Université Paris Diderot - Paris 7
39 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
40 ENBREC - European Network of Bipolar Research Expert Centres
41 Department of Psychiatry [Philadelphia]
42 Physiopathologie des Maladies du Système Nerveux Central
43 UPMC - Unité de recherche Phytopharmacie et Médiateurs Chimiques
44 Max Planck Institute of Psychiatry
45 Massachusetts General Hospital [Boston, MA, USA]
46 University of Iowa [Iowa City]
47 Edin. - University of Edinburgh
48 Royal Hospital for Sick Children [Edinburgh]
49 The Scripps Research Institute [La Jolla, San Diego]
50 SGDP - MRC Social, Genetic and Developmental Psychiatry Centre
51 Institute of Medical Sciences
52 SGDP - Social, Genetic and Developmental Psychiatry Centre
53 Department of Genetic Epidemiology in Psychiatry [Mannhein]
54 Department of Psychiatry
55 Department of Psychiatry
56 School of Nursing
57 Donders Center for Cognitive Neuroimaging
58 Department of Psychiatry and Human Behavior
59 Friedman Brain Institute, Mount Sinai
60 Seaver Autism Center for Research and Treatment
61 Department of Psychiatry
62 Department of Neuroscience
63 Departments of Psychiatry, Genetics and Genomic Sciences
64 Friedman Brain Institute
65 The Mindich Child Health and Development Institute
66 Department of Psychiatry
67 Department of Psychiatry, School of Clinical and Experimental Medicine
68 Department of Human Genetics, Los Angeles
69 McKusick-Nathans Institute of Genetic Medicine
70 King‘s College London
71 Stanley Center for Psychiatric Research
72 Mental Health Sciences Unit
73 Department of Genomics, Life and Brain Center
74 Institute of Human Genetics
75 INM-1 - Institute of Neuroscience and Medicine
76 Academic Department of Child and Adolescent Psychiatry, Institute of Psychiatry
77 Department of Disability and Human Development
78 Department of Developmental Neuroscience
79 Neuropsychiatric Genetics Research Group
80 Department of Psychiatry
81 Department of Psychiatry
82 John P. Hussman Institute for Human Genomics
83 East London NHS Foundation Trust
84 Max-Planck-Institut für Psychiatrie
85 Genetics Institute
86 Autism Speaks and the Department of Psychiatry
87 School of Neurology, Neurobiology and Psychiatry
88 Medstar Research Institute
89 KG Jebsen Centre for Psychosis Research
90 Deparment of Medical Genetics
91 Human Genetics Branch
92 Psychiatric and Neurodevelopmental Genetics Unit
93 Department of Psychiatry and Behavioral Sciences
94 Department of Non-Communicable Disease Epidemiology
95 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
96 Psychology Department
97 Department of Biochemistry and Molecular Biology, Department of Medical and Molecular Genetics
98 ACoRD - Academic Centre on Rare Diseases
99 IMRB - Institut Mondor de Recherche Biomédicale
100 Service de psychiatrie
101 Virginia Institute of Psychiatric and Behavioral Genetics
102 University of Dundee School of Medicine
103 Department of Biostatistics and Center for Statistical Genetics
104 Department of Child Psychiatry
105 Department of Psychiatry
106 Department of Psychiatry and Behavioral Sciences
107 Department of Psychiatry
108 Center for Neurobehavioral Genetics
109 Department of Genomics
110 Department of Molecular Medicine
111 Department of Psychiatry
112 Department of Neurology
113 MRC Centre for Neuropsychiatric Genetics and Genomics
114 Department of Psychiatry [Pittsburgh]
115 Fisico-Quimica Biologica
116 Vanderbilt Brain Institute
117 Department of Pediatrics
118 The Center for Applied Genomics
119 Stanford School of Medicine [Stanford]
120 Institute for Human Genetics
121 Neurosciences Centre of Excellence in Drug Discovery
122 Center for Genomic Medicine
123 Department of Clinical and Developmental Psychology
124 Clinical Research Unit
125 Functional Genomics
126 Neuronal Plasticity / Mouse Behaviour
127 Department of Psychiatry
128 MEB - Department of Medical Epidemiology and Biostatistics
129 Autism and Communicative Disorders Centre
130 Center for Human Genetic Research
131 Department of Psychiatry and Behavioral Sciences
132 Bioinformatics Research Center
133 Department of Neuroscience
134 MSSM - Icahn School of Medicine at Mount Sinai [New York]
135 Department of Psychiatry and Behavioral Sciences
136 Psychiatric Neurogenetics Section
137 School of Medicine
138 Institute of Human Genetics [Erlangen, Allemagne]
139 Division of Molecular Genome Analysis
140 Department of Ecology and Evolutionary Biology
141 Insitute of Neuroscience and Physiology
142 IG - Institut de Génomique d'Evry
143 Developmental Brain and Behaviour Unit
144 Division of Psychiatric Genomics
145 Institute of Human Genetics
146 Statistical Genetics Group
147 Department of Human Genetics
148 Department of Pharmacy and Biotechnology
149 Department of Psychiatry and Psychotherapy
150 Department of Mental Health
151 W.M. Keck Biotechnology Resource Laboratory
152 Institutes of Neuroscience and Health and Society
153 Genetic Epidemiology Unit
154 Queensland Institute of Medical Research
155 Department of Biomedicine and the Centre for Integrative Sequencing
156 Sorlandet Hospital HF
157 Division of Psychiatry
158 Medical Genetics Section
159 Department of Psychiatry
160 Unit on the Genetic Basis of Mood and Anxiety Disorders
161 UNDA - Unidade de Neurodesenvolvimento e Autismo
162 Division of Mental Health and Addiction
163 Division of Mental Health and Addiction
164 Molecular Psychiatry Laboratory
165 Research and Development
166 Department of Psychiatry
167 Registo Oncológico Regional-Sul
168 The Wellcome Trust Centre for Human Genetics [Oxford]
169 Department of Psychiatry
170 Department of Psychiatry and Human Behavior
171 Department of Molecular Biology, Cell Biology and Biochemistry
172 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
173 Human Genetics Department
174 Department of Psychiatry
175 Institute for Biomedical Imaging and Life Science
176 Department of Psychiatry
177 Head of Medical Sequencing
178 Program in Genetics and Genomic Biology
179 The Centre for Applied Genomics, Toronto
180 Carolina Institute for Developmental Disabilities
181 Department of Psychiatry and Behavioral Sciences
182 Department of Psychiatry
183 Analytic and Translational Genetics Unit
184 Rush University Medical Center [Chicago]
185 Department of Psychiatry
186 WUSTL - Washington University in Saint Louis
187 Department of Statistics
188 Department of Experimental Clinical and Health Psychology
189 Department of Child and Adolescent Psychiatry
190 Department of Medicine
191 Departments of Psychiatry and Genetics
192 Department of Psychiatry
193 Department of Psychiatry
194 Free University of Amsterdam
195 Department of Psychiatry and Behavioral Sciences [Stanford]
196 Pathology and Laboratory Medicine
197 The Scripps Translational Science Institute and The Scripps Research Institute
198 Department of Psychiatry and Psychotherapy
199 Psychiatric Center Nordbaden
200 Division of Cancer Epidemiology and Genetics
201 The Scripps Translational Science Institute and Scripps Health
202 Department of Experimental Clinical and Health Psychology
203 Child and Adolescent Psychiatry
204 Molecular Neuropsychiatry and Development Laboratory
205 Department of Psychiatry
206 Department of Molecular Physiology & Biophysics and Psychiatry
207 Department of Psychiatry and Behavioural Neurosciences
208 TGen - The Translational Genomics Research Institute
209 Oxford Health NHS Foundation Trust
210 Department of Psychiatry
211 INSA - Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
212 BioFIG
213 Battelle Center for Mathematical Medicine
214 Department of Psychiatry
215 Diamantina Institute
216 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
217 Department of Psychiatry
218 Departments of Biostatistics and Medicine
219 ArcelorMittal Maizières Research SA
220 Institute of Mental Health
221 Department of Mental Health
222 Department of Psychiatry
223 Department of Psychiatry
Hong S. Lee
  • Fonction : Auteur
Queensland Brain Institute
Stephan Ripke
  • Fonction : Auteur
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Broad Institute of MIT and Harvard
Benjamin M. Neale
  • Fonction : Auteur
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Broad Institute of MIT and Harvard
Stephen V. Faraone
  • Fonction : Auteur
SUNY Upstate Medical University
Shaun M. Purcell
  • Fonction : Auteur
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Broad Institute of MIT and Harvard
Mount Sinai School of Medicine
Roy H. Perlis
  • Fonction : Auteur
Broad Institute of MIT and Harvard
Psychiatric and Neurodevelopmental Genetics Unit
Bryan J. Mowry
  • Fonction : Auteur
Queensland Brain Institute
Queensland Centre for Mental Health Research
Anita Thapar
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Michael E. Goddard
  • Fonction : Auteur
New South Wales Department of Primary Industries
John S. Witte
  • Fonction : Auteur
Faculty of Land and Food Resources
University of Melbourne
Devin Absher
  • Fonction : Auteur
HudsonAlpha Institute for Biotechnology [Huntsville, AL]
Ingrid Agartz
  • Fonction : Auteur
Institute of Clinical Medicine [Oslo]
Diakonhjemmet Hospital
Huda Akil
  • Fonction : Auteur
University of Michigan [Ann Arbor]
Molecular and Behavioral Neuroscience Institute
Farooq Amin
  • Fonction : Auteur
Emory University [Atlanta, GA]
Ole A. Andreassen
  • Fonction : Auteur
Institute of Clinical Medicine [Oslo]
Oslo University Hospital [Oslo]
Adebayo Anjorin
  • Fonction : Auteur
University College of London [London]
Richard Anney
  • Fonction : Auteur
Trinity College Dublin
Verneri Anttila
  • Fonction : Auteur
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Dan E. Arking
  • Fonction : Auteur
Johns Hopkins University School of Medicine [Baltimore]
Philip Asherson
  • Fonction : Auteur
MRC Social Genetic Developmental and Psychiatry Centre
Maria H. Azevedo
  • Fonction : Auteur
University of Coimbra [Portugal]
Lena Backlund
  • Fonction : Auteur
Karolinska Institutet [Stockholm]
Judith A. Badner
  • Fonction : Auteur
University of Chicago
Anthony J. Bailey
  • Fonction : Auteur
University of British Columbia
Tobias Banaschewski
Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]
Jack D. Barchas
  • Fonction : Auteur
Weill Medical College of Cornell University [New York]
Michael R. Barnes
  • Fonction : Auteur
GlaxoSmithKline
Thomas B. Barrett
  • Fonction : Auteur
Portland Veterans Administration Medical Center
Nicholas Bass
  • Fonction : Auteur
Windeyer Institute for Medical Sciences
University College of London [London]
Agatino Battaglia
  • Fonction : Auteur
IRCCS Fondazione Stella Maris [Pisa]
Michael Bauer
University Hospital Carl Gustav Carus [Dresden, Germany]
Mònica Bayés
  • Fonction : Auteur
Centro Nacional de Analisis Genomico [Barcelona]
Frank Bellivier
Institut National de la Santé et de la Recherche Médicale
Université Paris Diderot - Paris 7
Assistance publique - Hôpitaux de Paris (AP-HP)
European Network of Bipolar Research Expert Centres
Sarah E. Bergen
  • Fonction : Auteur
Broad Institute of MIT and Harvard
Massachusetts General Hospital [Boston]
Karolinska Institutet [Stockholm]
Wade Berrettini
  • Fonction : Auteur
Department of Psychiatry [Philadelphia]
Catalina Betancur
Physiopathologie des Maladies du Système Nerveux Central
Institut National de la Santé et de la Recherche Médicale
Unité de recherche Phytopharmacie et Médiateurs Chimiques
Thomas Bettecken
  • Fonction : Auteur
Max Planck Institute of Psychiatry
Joseph Biederman
  • Fonction : Auteur
Massachusetts General Hospital [Boston, MA, USA]
Elisabeth B. Binder
  • Fonction : Auteur
Max Planck Institute of Psychiatry
Donald W. Black
  • Fonction : Auteur
University of Iowa [Iowa City]
Douglas H. R. Blackwood
  • Fonction : Auteur
University of Edinburgh
Royal Hospital for Sick Children [Edinburgh]
Cinnamon S. Bloss
  • Fonction : Auteur
The Scripps Research Institute [La Jolla, San Diego]
Michael Boehnke
  • Fonction : Auteur
University of Michigan [Ann Arbor]
Dorret I. Boomsma
  • Fonction : Auteur
Gerome Breen
MRC Social, Genetic and Developmental Psychiatry Centre
Institute of Medical Sciences
Social, Genetic and Developmental Psychiatry Centre
René Breuer
  • Fonction : Auteur
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Richard Bruggeman
  • Fonction : Auteur
Department of Psychiatry
Paul Cormican
  • Fonction : Auteur
Department of Psychiatry
Nancy G. Buccola
  • Fonction : Auteur
School of Nursing
Jan K. Buitelaar
  • Fonction : Auteur
Donders Center for Cognitive Neuroimaging
William E. Bunney
  • Fonction : Auteur
Department of Psychiatry and Human Behavior
Joseph D. Buxbaum
  • Fonction : Auteur
Friedman Brain Institute, Mount Sinai
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Department of Neuroscience
Departments of Psychiatry, Genetics and Genomic Sciences
Friedman Brain Institute
The Mindich Child Health and Development Institute
William F. Byerley
  • Fonction : Auteur
Department of Psychiatry
Enda M. Byrne
  • Fonction : Auteur
Queensland Brain Institute
Sian Caesar
  • Fonction : Auteur
Department of Psychiatry, School of Clinical and Experimental Medicine
Wiepke Cahn
  • Fonction : Auteur
Department of Psychiatry
Rita M. Cantor
  • Fonction : Auteur
Department of Human Genetics, Los Angeles
Miguel Casas
  • Fonction : Auteur
Department of Psychiatry
Aravinda Chakravarti
  • Fonction : Auteur
McKusick-Nathans Institute of Genetic Medicine
King‘s College London
Kimberly Chambert
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Khalid Choudhury
  • Fonction : Auteur
Mental Health Sciences Unit
Sven Cichon
  • Fonction : Auteur
Department of Genomics, Life and Brain Center
Institute of Human Genetics
Institute of Neuroscience and Medicine
Robert C. Cloninger
  • Fonction : Auteur
Department of Psychiatry
David A. Collier
  • Fonction : Auteur
MRC Social, Genetic and Developmental Psychiatry Centre
Social, Genetic and Developmental Psychiatry Centre
Academic Department of Child and Adolescent Psychiatry, Institute of Psychiatry
Edwin H. Cook
  • Fonction : Auteur
Department of Disability and Human Development
Hilary Coon
  • Fonction : Auteur
Department of Developmental Neuroscience
Bru Cormand
  • Fonction : Auteur
Department of Psychiatry
Aiden Corvin
  • Fonction : Auteur
Department of Psychiatry
Neuropsychiatric Genetics Research Group
William H. Coryell
  • Fonction : Auteur
Department of Psychiatry
David W. Craig
  • Fonction : Auteur
Department of Psychiatry
Ian W. Craig
  • Fonction : Auteur
MRC Social, Genetic and Developmental Psychiatry Centre
Jennifer Crosbie
  • Fonction : Auteur
Department of Psychiatry
Michael L. Cuccaro
  • Fonction : Auteur
John P. Hussman Institute for Human Genomics
David Curtis
  • Fonction : Auteur
East London NHS Foundation Trust
Darina Czamara
Max-Planck-Institut für Psychiatrie
Susmita Datta
  • Fonction : Auteur
Genetics Institute
Geraldine Dawson
  • Fonction : Auteur
Autism Speaks and the Department of Psychiatry
Richard Day
  • Fonction : Auteur
School of Neurology, Neurobiology and Psychiatry
Eco J. de Geus
Medstar Research Institute
Franziska Degenhardt
  • Fonction : Auteur
Department of Genomics, Life and Brain Center
Institute of Human Genetics
Srdjan Djurovic
  • Fonction : Auteur
KG Jebsen Centre for Psychosis Research
Deparment of Medical Genetics
Gary J. Donohoe
  • Fonction : Auteur
Department of Psychiatry
Human Genetics Branch
Alysa E. Doyle
  • Fonction : Auteur
Psychiatric and Neurodevelopmental Genetics Unit
Jubao Duan
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Frank Dudbridge
  • Fonction : Auteur
Department of Non-Communicable Disease Epidemiology
Eftichia Duketis
  • Fonction : Auteur
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
Richard P. Ebstein
  • Fonction : Auteur
Psychology Department
Howard J. Edenberg
  • Fonction : Auteur
Department of Biochemistry and Molecular Biology, Department of Medical and Molecular Genetics
Josephine Elia
  • Fonction : Auteur
Department of Psychiatry
Sean Ennis
  • Fonction : Auteur
Academic Centre on Rare Diseases
Bruno Etain
Institut Mondor de Recherche Biomédicale
Service de psychiatrie
CV
Ayman Fanous
  • Fonction : Auteur
Virginia Institute of Psychiatric and Behavioral Genetics
Anne E. Farmer
  • Fonction : Auteur
MRC Social, Genetic and Developmental Psychiatry Centre
Social, Genetic and Developmental Psychiatry Centre
I Nicol Ferrier
  • Fonction : Auteur
University of Dundee School of Medicine
Matthew Flickinger
  • Fonction : Auteur
Department of Biostatistics and Center for Statistical Genetics
Eric Fombonne
  • Fonction : Auteur
Department of Child Psychiatry
Tatiana Foroud
  • Fonction : Auteur
Department of Psychiatry
Josef Frank
Department of Psychiatry and Behavioral Sciences
Barbara Franke
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Christine Fraser
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Robert Freedman
  • Fonction : Auteur
Department of Psychiatry
Nelson B. Freimer
  • Fonction : Auteur
Center for Neurobehavioral Genetics
Christine M. Freitag
  • Fonction : Auteur
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
Marion Friedl
  • Fonction : Auteur
Department of Genomics
Louise Frisén
  • Fonction : Auteur
Department of Molecular Medicine
Louise Gallagher
  • Fonction : Auteur
Department of Psychiatry
Pablo V. Gejman
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Lyudmila Georgieva
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Elliot S. Gershon
  • Fonction : Auteur
Department of Psychiatry
Daniel H. Geschwind
  • Fonction : Auteur
Department of Neurology
Ina Giegling
  • Fonction : Auteur
Department of Genomics
Michael Gill
  • Fonction : Auteur
Department of Psychiatry
Scott D. Gordon
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Katherine Gordon-Smith
  • Fonction : Auteur
MRC Centre for Neuropsychiatric Genetics and Genomics
Department of Psychiatry, School of Clinical and Experimental Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics
Elaine K. Green
  • Fonction : Auteur
MRC Centre for Neuropsychiatric Genetics and Genomics
Tiffany A. Greenwood
  • Fonction : Auteur
Department of Psychiatry
Dorothy E. Grice
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
Magdalena Gross
  • Fonction : Auteur
Fisico-Quimica Biologica
Detelina Grozeva
MRC Centre for Neuropsychiatric Genetics and Genomics
MRC Centre for Neuropsychiatric Genetics and Genomics
Weihua Guan
  • Fonction : Auteur
Department of Biostatistics and Center for Statistical Genetics
Fisico-Quimica Biologica
Hugh Gurling
  • Fonction : Auteur
Mental Health Sciences Unit
Lieuwe de Haan
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
Jonathan L. Haines
  • Fonction : Auteur
Vanderbilt Brain Institute
Hakon Hakonarson
Department of Pediatrics
The Center for Applied Genomics
Joachim Hallmayer
  • Fonction : Auteur
Stanford School of Medicine [Stanford]
Steven P. Hamilton
  • Fonction : Auteur
Institute for Human Genetics
Marian L. Hamshere
  • Fonction : Auteur
MRC Centre for Neuropsychiatric Genetics and Genomics
MRC Centre for Neuropsychiatric Genetics and Genomics
Neurosciences Centre of Excellence in Drug Discovery
Thomas F. Hansen
  • Fonction : Auteur
Center for Genomic Medicine
Annette M. Hartmann
  • Fonction : Auteur
Department of Genomics
Martin Hautzinger
  • Fonction : Auteur
Department of Clinical and Developmental Psychology
Andrew C. Heath
  • Fonction : Auteur
King‘s College London
Anjali K. Henders
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
Stefan Herms
Department of Genomics
Ian B. Hickie
  • Fonction : Auteur
Clinical Research Unit
Maria Hipolito
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Susanne Hoefels
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
Peter A. Holmans
  • Fonction : Auteur
Functional Genomics
MRC Centre for Neuropsychiatric Genetics and Genomics
Florian Holsboer
  • Fonction : Auteur
Neuronal Plasticity / Mouse Behaviour
Witte J. Hoogendijk
  • Fonction : Auteur
Department of Psychiatry
Jouke-Jan Hottenga
  • Fonction : Auteur
King‘s College London
Christina M. Hultman
  • Fonction : Auteur
Department of Medical Epidemiology and Biostatistics
Vanessa Hus
  • Fonction : Auteur
Autism and Communicative Disorders Centre
Andrés Ingason
  • Fonction : Auteur
Center for Genomic Medicine
Marcus Ising
  • Fonction : Auteur
Center for Human Genetic Research
Stéphane Jamain
Institut Mondor de Recherche Biomédicale
CV
Edward G. Jones
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Ian Jones
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Lisa Jones
  • Fonction : Auteur
Department of Psychiatry, School of Clinical and Experimental Medicine
Jung-Ying Tzeng
  • Fonction : Auteur
Bioinformatics Research Center
Anna K. Kähler
  • Fonction : Auteur
Department of Neuroscience
René Sylvain Kahn
  • Fonction : Auteur
Icahn School of Medicine at Mount Sinai [New York]
Radhika Kandaswamy
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Mental Health Sciences Unit
Matthew C. Keller
  • Fonction : Auteur
Department of Neuroscience
James L. Kennedy
  • Fonction : Auteur
Psychiatric Neurogenetics Section
Elaine Kenny
  • Fonction : Auteur
Department of Psychiatry
Human Genetics Branch
Lindsey Kent
  • Fonction : Auteur
School of Medicine
Yunjung Kim
  • Fonction : Auteur
Bioinformatics Research Center
George K. Kirov
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Institute of Human Genetics [Erlangen, Allemagne]
Sabine M. Klauck
  • Fonction : Auteur
Division of Molecular Genome Analysis
Lambertus Klei
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
James A. Knowles
  • Fonction : Auteur
Department of Ecology and Evolutionary Biology
Martin A. Kohli
  • Fonction : Auteur
Center for Human Genetic Research
Daniel L. Koller
  • Fonction : Auteur
Department of Psychiatry
Bettina Konte
  • Fonction : Auteur
Medstar Research Institute
Ania Korszun
  • Fonction : Auteur
MRC Centre for Neuropsychiatric Genetics and Genomics
Lydia Krabbendam
  • Fonction : Auteur
Department of Neuroscience
Robert Krasucki
  • Fonction : Auteur
Mental Health Sciences Unit
Jonna Kuntsi
MRC Social, Genetic and Developmental Psychiatry Centre
Phoenix Kwan
  • Fonction : Auteur
Department of Biostatistics and Center for Statistical Genetics
Mikael Landén
Department of Medical Epidemiology and Biostatistics
Insitute of Neuroscience and Physiology
Niklas Långström
  • Fonction : Auteur
Insitute of Neuroscience and Physiology
Mark Lathrop
  • Fonction : Auteur
Institut de Génomique d'Evry
Jacob Lawrence
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Mental Health Sciences Unit
William B. Lawson
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Marion Leboyer
Institut Mondor de Recherche Biomédicale
Service de psychiatrie
David H. Ledbetter
  • Fonction : Auteur
Developmental Brain and Behaviour Unit
Phil H. Lee
  • Fonction : Auteur
Psychiatric and Neurodevelopmental Genetics Unit
Todd Lencz
  • Fonction : Auteur
Division of Psychiatric Genomics
Klaus-Peter Lesch
  • Fonction : Auteur
Institute of Human Genetics
Douglas F. Levinson
  • Fonction : Auteur
Developmental Brain and Behaviour Unit
Cathryn M. Lewis
  • Fonction : Auteur
MRC Social, Genetic and Developmental Psychiatry Centre
MRC Centre for Neuropsychiatric Genetics and Genomics
Statistical Genetics Group
Jun Li
Department of Human Genetics
Paul Lichtenstein
  • Fonction : Auteur
Department of Medical Epidemiology and Biostatistics
Jeffrey A. Lieberman
  • Fonction : Auteur
Institute of Human Genetics
Dan-Yu Lin
  • Fonction : Auteur
Bioinformatics Research Center
Don H. Linszen
  • Fonction : Auteur
Institute of Human Genetics
Chunyu Liu
  • Fonction : Auteur
Bioinformatics Research Center
Falk W. Lohoff
  • Fonction : Auteur
Department of Psychiatry [Philadelphia]
Sandra K. Loo
  • Fonction : Auteur
Bioinformatics Research Center
Catherine Lord
  • Fonction : Auteur
Autism and Communicative Disorders Centre
Jennifer K. Lowe
  • Fonction : Auteur
Fisico-Quimica Biologica
Susanne Lucae
  • Fonction : Auteur
Max Planck Institute of Psychiatry
Donald J. Macintyre
  • Fonction : Auteur
Developmental Brain and Behaviour Unit
Pamela A. F. Madden
  • Fonction : Auteur
Medstar Research Institute
Elena Maestrini
  • Fonction : Auteur
Department of Pharmacy and Biotechnology
Patrik K. E. Magnusson
  • Fonction : Auteur
Department of Psychiatry and Psychotherapy
Pamela B. Mahon
  • Fonction : Auteur
Department of Mental Health
Wolfgang Maier
  • Fonction : Auteur
Department of Psychiatry and Psychotherapy
Anil K. Malhotra
  • Fonction : Auteur
Division of Psychiatric Genomics
Shrikant M. Mane
  • Fonction : Auteur
W.M. Keck Biotechnology Resource Laboratory
Christa L. Martin
  • Fonction : Auteur
Institutes of Neuroscience and Health and Society
Nicholas G. Martin
  • Fonction : Auteur
Genetic Epidemiology Unit
Queensland Institute of Medical Research
Manuel Mattheisen
  • Fonction : Auteur
Institute of Human Genetics
Department of Biomedicine and the Centre for Integrative Sequencing
Keith Matthews
  • Fonction : Auteur
University of Dundee School of Medicine
Morten Mattingsdal
  • Fonction : Auteur
KG Jebsen Centre for Psychosis Research
Institute of Clinical Medicine [Oslo]
Sorlandet Hospital HF
Steven A. Mccarroll
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Kevin A. Mcghee
  • Fonction : Auteur
Division of Psychiatry
Medical Genetics Section
James J. Mcgough
  • Fonction : Auteur
Institutes of Neuroscience and Health and Society
Patrick J. Mcgrath
  • Fonction : Auteur
Institutes of Neuroscience and Health and Society
Peter Mcguffin
  • Fonction : Auteur
MRC Social, Genetic and Developmental Psychiatry Centre
Social, Genetic and Developmental Psychiatry Centre
Melvin G. Mcinnis
  • Fonction : Auteur
Department of Psychiatry
Andrew Mcintosh
  • Fonction : Auteur
Division of Psychiatry
Medical Genetics Section
Rebecca Mckinney
  • Fonction : Auteur
Department of Psychiatry
Alan W. Mclean
  • Fonction : Auteur
Division of Psychiatry
Medical Genetics Section
Francis J. Mcmahon
  • Fonction : Auteur
Unit on the Genetic Basis of Mood and Anxiety Disorders
Human Genetics Branch
William M. Mcmahon
  • Fonction : Auteur
Department of Developmental Neuroscience
Andrew Mcquillin
Mental Health Sciences Unit
Helena Medeiros
  • Fonction : Auteur
Unidade de Neurodesenvolvimento e Autismo
Sarah E. Medland
  • Fonction : Auteur
Medstar Research Institute
Sandra Meier
  • Fonction : Auteur
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Ingrid Melle
  • Fonction : Auteur
KG Jebsen Centre for Psychosis Research
Division of Mental Health and Addiction
Institute of Clinical Medicine [Oslo]
Division of Mental Health and Addiction
Fan Meng
  • Fonction : Auteur
Molecular Psychiatry Laboratory
Jobst Meyer
  • Fonction : Auteur
Institutes of Neuroscience and Health and Society
Christel M. Middeldorp
  • Fonction : Auteur
King‘s College London
Lefkos Middleton
  • Fonction : Auteur
Research and Development
Vihra Milanova
  • Fonction : Auteur
Department of Psychiatry
Ana Miranda
  • Fonction : Auteur
Registo Oncológico Regional-Sul
Anthony P. Monaco
  • Fonction : Auteur
The Wellcome Trust Centre for Human Genetics [Oxford]
Grant W. Montgomery
  • Fonction : Auteur
Genetic Epidemiology Unit
Queensland Institute of Medical Research
Jennifer L. Moran
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Daniel Moreno-De-Luca
  • Fonction : Auteur
Physiopathologie des Maladies du Système Nerveux Central
Gunnar Morken
  • Fonction : Auteur
Department of Neuroscience
Department of Psychiatry
Derek W. Morris
  • Fonction : Auteur
Department of Psychiatry
Neuropsychiatric Genetics Research Group
Eric M. Morrow
  • Fonction : Auteur
Department of Psychiatry and Human Behavior
Department of Molecular Biology, Cell Biology and Biochemistry
Valentina Moskvina
  • Fonction : Auteur
MRC Centre for Neuropsychiatric Genetics and Genomics
Institute of Human Genetics [Erlangen, Allemagne]
Pierandrea Muglia
  • Fonction : Auteur
Neurosciences Centre of Excellence in Drug Discovery
Thomas W. Mühleisen
  • Fonction : Auteur
Institute of Human Genetics
Department of Genomics, Life and Brain Center
Walter J. Muir
  • Fonction : Auteur
Division of Psychiatry
Medical Genetics Section
Bertram Müller-Myhsok
Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
Michael Murtha
  • Fonction : Auteur
Institute of Human Genetics
Richard M. Myers
  • Fonction : Auteur
HudsonAlpha Institute for Biotechnology [Huntsville, AL]
Inez Myin-Germeys
  • Fonction : Auteur
Max Planck Institute of Psychiatry
Michael C. Neale
  • Fonction : Auteur
Virginia Institute of Psychiatric and Behavioral Genetics
Stan F. Nelson
  • Fonction : Auteur
Institute of Human Genetics
Caroline M. Nievergelt
  • Fonction : Auteur
Department of Psychiatry
Ivan Nikolov
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Vishwajit Nimgaonkar
  • Fonction : Auteur
Human Genetics Department
Willem A. Nolen
  • Fonction : Auteur
Department of Psychiatry
Markus M. Nöthen
  • Fonction : Auteur
Institute of Human Genetics [Erlangen, Allemagne]
Institute of Human Genetics
John I. Nurnberger
  • Fonction : Auteur
Department of Psychiatry
Evaristus A. Nwulia
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Dale R. Nyholt
  • Fonction : Auteur
Medstar Research Institute
Colm O'Dushlaine
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Robert D. Oades
  • Fonction : Auteur
Max Planck Institute of Psychiatry
Ann Olincy
  • Fonction : Auteur
Department of Psychiatry
Guiomar Oliveira
  • Fonction : Auteur
Institute for Biomedical Imaging and Life Science
Unidade de Neurodesenvolvimento e Autismo
Line Olsen
  • Fonction : Auteur
Virginia Institute of Psychiatric and Behavioral Genetics
Center for Genomic Medicine
Roel A. Ophoff
  • Fonction : Auteur
Department of Psychiatry
Urban Osby
  • Fonction : Auteur
Department of Molecular Medicine
Michael J. Owen
  • Fonction : Auteur
Institute of Psychological Medicine and Clinical Neurosciences
MRC Centre for Neuropsychiatric Genetics and Genomics
Aarno Palotie
  • Fonction : Auteur
Head of Medical Sequencing
Jeremy R. Parr
  • Fonction : Auteur
Institutes of Neuroscience and Health and Society
Andrew D. Paterson
  • Fonction : Auteur
Program in Genetics and Genomic Biology
The Centre for Applied Genomics, Toronto
Carlos N. Pato
  • Fonction : Auteur
Virginia Institute of Psychiatric and Behavioral Genetics
Michele T. Pato
  • Fonction : Auteur
Virginia Institute of Psychiatric and Behavioral Genetics
Brenda W. Penninx
  • Fonction : Auteur
Genetic Epidemiology Unit
Michele L. Pergadia
  • Fonction : Auteur
Medstar Research Institute
Margaret A. Pericak-Vance
  • Fonction : Auteur
John P. Hussman Institute for Human Genomics
Benjamin S. Pickard
  • Fonction : Auteur
Division of Psychiatry
Medical Genetics Section
Jonathan Pimm
  • Fonction : Auteur
Mental Health Sciences Unit
Joseph Piven
  • Fonction : Auteur
Carolina Institute for Developmental Disabilities
Danielle Posthuma
  • Fonction : Auteur
Functional Genomics
James B. Potash
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Department of Psychiatry
Fritz Poustka
  • Fonction : Auteur
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
Peter Propping
  • Fonction : Auteur
Institute of Human Genetics
Vinay Puri
  • Fonction : Auteur
Mental Health Sciences Unit
Digby J. Quested
  • Fonction : Auteur
Department of Psychiatry
Emma M. Quinn
  • Fonction : Auteur
Division of Psychiatric Genomics
Department of Psychiatry
Neuropsychiatric Genetics Research Group
Josep Antoni Ramos-Quiroga
  • Fonction : Auteur
Department of Psychiatry
Henrik B. Rasmussen
  • Fonction : Auteur
Department of Psychiatry
Center for Genomic Medicine
Soumya Raychaudhuri
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Analytic and Translational Genetics Unit
Karola Rehnström
  • Fonction : Auteur
Rush University Medical Center [Chicago]
Andreas Reif
Department of Psychiatry
Marta Ribasés
  • Fonction : Auteur
Department of Psychiatry
John P. Rice
  • Fonction : Auteur
Washington University in Saint Louis
Marcella Rietschel
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Kathryn Roeder
  • Fonction : Auteur
Department of Statistics
Herbert Roeyers
  • Fonction : Auteur
Department of Experimental Clinical and Health Psychology
Lizzy Rossin
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Aribert Rothenberger
  • Fonction : Auteur
Department of Child and Adolescent Psychiatry
Guy Rouleau
Department of Medicine
Douglas Ruderfer
  • Fonction : Auteur
Division of Psychiatric Genomics
Dan Rujescu
  • Fonction : Auteur
Department of Genomics
Alan R. Sanders
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences
Stephan J. Sanders
  • Fonction : Auteur
Departments of Psychiatry and Genetics
Susan L. Santangelo
  • Fonction : Auteur
Department of Psychiatry
Department of Psychiatry
Joseph A. Sergeant
  • Fonction : Auteur
Free University of Amsterdam
Russell Schachar
  • Fonction : Auteur
Department of Psychiatry
Martin Schalling
  • Fonction : Auteur
Department of Molecular Medicine
Alan F. Schatzberg
  • Fonction : Auteur
Department of Psychiatry and Behavioral Sciences [Stanford]
William A. Scheftner
  • Fonction : Auteur
Rush University Medical Center [Chicago]
Gerard D. Schellenberg
  • Fonction : Auteur
Pathology and Laboratory Medicine
Stephen W. Scherer
  • Fonction : Auteur
Program in Genetics and Genomic Biology
The Centre for Applied Genomics, Toronto
Nicholas J. Schork
  • Fonction : Auteur
The Scripps Translational Science Institute and The Scripps Research Institute
Thomas G. Schulze
  • Fonction : Auteur
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Human Genetics Branch
Department of Psychiatry and Behavioral Sciences
Department of Psychiatry and Psychotherapy
Johannes Schumacher
  • Fonction : Auteur
Institute of Human Genetics
Markus Schwarz
  • Fonction : Auteur
Psychiatric Center Nordbaden
Edward Scolnick
  • Fonction : Auteur
Stanley Center for Psychiatric Research
Laura J. Scott
  • Fonction : Auteur
Department of Biostatistics and Center for Statistical Genetics
Jianxin Shi
  • Fonction : Auteur
Division of Cancer Epidemiology and Genetics
Paul D. Shilling
  • Fonction : Auteur
Department of Psychiatry
Stanley I. Shyn
  • Fonction : Auteur
Department of Psychiatry
Jeremy M. Silverman
  • Fonction : Auteur
Department of Psychiatry [Pittsburgh]
Susan L. Slager
  • Fonction : Auteur
Department of Psychiatry
Susan L. Smalley
  • Fonction : Auteur
Department of Psychiatry
Johannes H. Smit
  • Fonction : Auteur
Genetic Epidemiology Unit
Medstar Research Institute
Erin N. Smith
  • Fonction : Auteur
The Scripps Translational Science Institute and Scripps Health
Edmund J. S. Sonuga-Barke
  • Fonction : Auteur
Developmental Brain and Behaviour Unit
Department of Experimental Clinical and Health Psychology
David St Clair
  • Fonction : Auteur
Institute of Medical Sciences
Matthew State
  • Fonction : Auteur
Institute of Human Genetics
Michael Steffens
  • Fonction : Auteur
Department of Biomedicine and the Centre for Integrative Sequencing
Hans-Christoph Steinhausen
  • Fonction : Auteur
Child and Adolescent Psychiatry
John S. Strauss
  • Fonction : Auteur
Molecular Neuropsychiatry and Development Laboratory
Jana Strohmaier
  • Fonction : Auteur
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Scott T. Stroup
  • Fonction : Auteur
Department of Psychiatry
James S. Sutcliffe
  • Fonction : Auteur
Vanderbilt Brain Institute
Department of Psychiatry
Department of Molecular Physiology & Biophysics and Psychiatry
Peter Szatmari
  • Fonction : Auteur
Department of Psychiatry and Behavioural Neurosciences
Szabocls Szelinger
  • Fonction : Auteur
The Translational Genomics Research Institute
Srinivasa Thirumalai
  • Fonction : Auteur
Oxford Health NHS Foundation Trust
Robert C. Thompson
  • Fonction : Auteur
Molecular Psychiatry Laboratory
Department of Psychiatry and Human Behavior
Alexandre A. Todorov
  • Fonction : Auteur
Department of Psychiatry
Federica Tozzi
  • Fonction : Auteur
Neurosciences Centre of Excellence in Drug Discovery
Jens Treutlein
  • Fonction : Auteur
Rush University Medical Center [Chicago]
Manfred Uhr
  • Fonction : Auteur
Center for Human Genetic Research
Edwin J. C. G. van den Oord
  • Fonction : Auteur
Department of Psychiatry
Gerard van Grootheest
  • Fonction : Auteur
Institute of Human Genetics
Jim van Os
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Institute of Human Genetics
Astrid M. Vicente
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Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
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Veronica J. Vieland
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Battelle Center for Mathematical Medicine
John B. Vincent
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Peter M. Visscher
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Queensland Brain Institute
Diamantina Institute
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Christopher A. Walsh
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Thomas H. Wassink
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Stanley J. Watson
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Myrna M. Weissman
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Thomas Werge
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Thomas F. Wienker
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Gonneke Willemsen
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Nigel Williams
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Jeremy A. Willsey
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Stephanie H. Witt
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Department of Genetic Epidemiology in Psychiatry [Mannhein]
Wei Xu
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Allan H. Young
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University of Dundee School of Medicine
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Timothy W. Yu
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Stanley Zammit
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Peter P. Zandi
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Peng Zhang
University of Michigan [Ann Arbor]
Frans G. Zitman
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Sebastian Zöllner
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Bernie Devlin
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John R. Kelsoe
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Pamela Sklar
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Division of Psychiatric Genomics
Mark J. Daly
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Michael C. O'Donovan
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Nicholas Craddock
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Patrick F. Sullivan
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Jordan W. Smoller
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Kenneth S. Kendler
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Naomi R. Wray
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Queensland Brain Institute

Résumé

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Domaines

Biochimie, Biologie Moléculaire
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Georges Guellaen  : Connectez-vous pour contacter le contributeur

https://inserm.hal.science/inserm-00864642

Soumis le : vendredi 28 mars 2014-15:06:49

Dernière modification le : mardi 19 novembre 2024-14:04:08

Archivage à long terme le : samedi 28 juin 2014-10:36:49

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Dates et versions

inserm-00864642 , version 1 (28-03-2014)

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Hong S. Lee, Stephan Ripke, Benjamin M. Neale, Stephen V. Faraone, Shaun M. Purcell, et al.. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 2013, 45 (9), pp.984-994. ⟨10.1038/ng.2711⟩. ⟨inserm-00864642⟩

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